• Melatonin For Fat Loss

      From Science Daily

      Spanish scientists have discovered that melatonin consumption helps control weight gain because it stimulates the appearance of 'beige fat', a type of fat cell that burns calories in vivo instead of storing them. White adipose tissue stores calories leading to weight gain whereas 'beige fat' (also known as 'good or thinning fat') helps regulate body weight control, hence its metabolic benefits.

      In the Journal of Pineal Research, scientists from the University of Granada Institute for Neuroscience, the Hospital Carlos III, Madrid, and the University of Texas Health Science Center in San Antonio (USA) have revealed, for the first time, the previously unknown enigma of why melatonin has metabolic benefits in treating diabetes and hyperlipidemia.

      In earlier publications, the researchers analysed the effects of melatonin on obesity, dyslipidemia, high blood pressure and type 2 diabetes mellitus associated with obesity in young obese diabetic Zucker rats -- an experimental model of metabolic syndrome.

      In view of their most recent results, it seems the key lies in the fact that chronic melatonin consumption not only induces the appearance of 'beige fat' in obese diabetic rats, but also increases its presence in thin animals used as a control group. 'Beige fat' cells are found in scattered lentil-sized deposits beneath the inguinal skin in obese diabetic Zucker rats.

      Melatonin is a natural hormone segregated by the human body itself and melatonin levels generally increase in the dark at night. It is also found in small quantities in fruit and vegetables like mustard, Goji berries, almonds, sunflower seeds, cardamom, fennel, coriander and cherries. These findings, together with the pharmacologically safe profile of melatonin, mean it is a potentially useful tool both in its own right and to complement the treatment of obesity. Sleeping in the dark and consuming these foodstuffs could help control weight gain and prevent cardiovascular diseases associated with obesity and dyslipidemia.

      The study -- coordinated by University of Granada lecturer Ahmad Agil -- showed that chronic administration of melatonin sensitizes the thermogenic effect of exposure to cold, heightens the thermogenic effect of exercise and, therefore, constitutes excellent therapy against obesity. The fact is that one of the key differences between 'beige fat', which appears when administering melatonin, and 'white fat', is that 'beige fat' cell mitochondria express levels of UCP1 protein, responsible for burning calories and generating heat.

      The study -- authored by Aroa Jiménez-Aranda, Gumersindo Fernández-Vázquez, Daniel Campos, Mohamed Tassi, Lourdes Velasco-Perez, Tx Tan, Russel J. Reiter and Ahmad Agil -- has been part-financed and supported by the Granada Research of Excellence Initiative on BioHealth (GREIB), the University of Granada Vice-Rectorate for Scientific Policy and Research, and the regional government of Andalusia research group CTS-109.

      Given the importance of this discovery, the researchers are confident they will obtain the funding needed to continue their work -- says principle researcher Ahmad Agil -- "and be able to achieve their final objective: to confirm these findings in humans, by administering melatonin to help combat obesity and diabetes."

      Story Source:
      The above story is based on materials provided by University of Granada.
      Note: Materials may be edited for content and length. For further information, please contact the source cited above.

      Journal Reference:
      Aroa Jiménez-Aranda, Gumersindo Fernández-Vázquez, Daniel Campos, Mohamed Tassi, Lourdes Velasco-Perez, Tx Tan, Russel J. Reiter and Ahmad Agil. Melatonin induces browning of inguinal white adipose tissue in diabetic fatty zucker rats. Journal of Pineal Research, 2013; September DOI: 10.1111/jpr.12089

      Source: http://www.sciencedaily.com/releases...0925091745.htm
      Comments 2 Comments
      1. middleageguy's Avatar
        middleageguy -
        Has anyone on the board done any further reading/research on this?
        Would like to know how many mg’s a human would need to supplement of melatonin to achieve ones body to “stimulates the appearance of 'beige fat',”?

        I’m not fat any more, not for a few years, but still not shredded, it sounds nice to use during a cut.

        I don’t think using the recommended mg of melatonin as sleep aid would do the trick.

        When I look at buying this in bulk one of the suppliers gives the below warning.
        As with any supplement there is a “potential for TOXICITY reactions”.

        Any members have any thoughts or can point to other articles?


        Melatonin is a hormone synthesized in both plants and animals from the amino acid L-tryptophan. In mammals, such as humans, it is secreted by the pineal gland and modulates the body's sleep pattern. Melatonin production in the body is triggered by darkness and inhibited by light, helping the body manage its natural rhythm.

        Because of the extremely small recommended serving size for this product, and the potential for TOXICITY reactions from excess use, do not purchase this product unless you are a compounding pharmacist or other health practice professional.
      1. SHortstack_86's Avatar
        SHortstack_86 -
        did some googleing and found this hope it helps vanderbilt.edu/AnS/psychology/health_psychology/melatonin.htm#Conclusions on Melatonin
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