• Link Between Omega 3 And Prostate Cancer?

      From Science Daily

      A second large, prospective study by scientists at Fred Hutchinson Cancer Research Center has confirmed the link between high blood concentrations of omega-3 fatty acids and an increased risk of prostate cancer.

      Published July 11 in the online edition of the Journal of the National Cancer Institute, the latest findings indicate that high concentrations of EPA, DPA and DHA -- the three anti-inflammatory and metabolically related fatty acids derived from fatty fish and fish-oil supplements -- are associated with a 71 percent increased risk of high-grade prostate cancer. The study also found a 44 percent increase in the risk of low-grade prostate cancer and an overall 43 percent increase in risk for all prostate cancers.

      The increase in risk for high-grade prostate cancer is important because those tumors are more likely to be fatal.

      The findings confirm a 2011 study published by the same Fred Hutch scientific team that reported a similar link between high blood concentrations of DHA and a more than doubling of the risk for developing high-grade prostate cancer. The latest study also confirms results from a large European study.

      "The consistency of these findings suggests that these fatty acids are involved in prostate tumorigenesis and recommendations to increase long-chain omega-3 fatty acid intake, in particular through supplementation, should consider its potential risks," the authors wrote.

      "We've shown once again that use of nutritional supplements may be harmful," said Alan Kristal, Dr.P.H., the paper's senior author and member of the Fred Hutch Public Health Sciences Division. Kristal also noted a recent analysis published in the Journal of the American Medical Association that questioned the benefit of omega-3 supplementation for cardiovascular diseases. The analysis, which combined the data from 20 studies, found no reduction in all-cause mortality, heart attacks or strokes.

      "What's important is that we have been able to replicate our findings from 2011 and we have confirmed that marine omega-3 fatty acids play a role in prostate cancer occurrence," said corresponding author Theodore Brasky, Ph.D., a research assistant professor at The Ohio State University Comprehensive Cancer Center who was a postdoctoral trainee at Fred Hutch when the research was conducted. "It's important to note, however, that these results do not address the question of whether omega-3's play a detrimental role in prostate cancer prognosis," he said.

      Kristal said the findings in both Fred Hutch studies were surprising because omega-3 fatty acids are believed to have a host of positive health effects based on their anti-inflammatory properties. Inflammation plays a role in the development and growth of many cancers.

      It is unclear from this study why high levels of omega-3 fatty acids would increase prostate cancer risk, according to the authors, however the replication of this finding in two large studies indicates the need for further research into possible mechanisms. One potentially harmful effect of omega-3 fatty acids is their conversion into compounds that can cause damage to cells and DNA, and their role in immunosuppression. Whether these effects impact cancer risk is not known.

      The difference in blood concentrations of omega-3 fatty acids between the lowest and highest risk groups was about 2.5 percentage points (3.2 percent vs. 5.7 percent), which is somewhat larger than the effect of eating salmon twice a week, Kristal said. The current study analyzed data and specimens collected from men who participated in the Selenium and Vitamin E Cancer Prevention Trial (SELECT), a large randomized, placebo-controlled trial to test whether selenium and vitamin E, either alone or combined, reduced prostate cancer risk. That study showed no benefit from selenium intake and an increase in prostate cancers in men who took vitamin E.

      The group included in the this analysis consisted of 834 men who had been diagnosed with incident, primary prostate cancers (156 were high-grade cancer) along with a comparison group of 1,393 men selected randomly from the 35,500 participants in SELECT. The National Cancer Institute and the National Center for Complementary and Alternative Medicine funded the research.

      Also participating in the study were additional Fred Hutch scientists and researchers from the University of Texas, University of California, University of Washington, National Cancer Institute and the Cleveland Clinic.

      Story Source:
      The above story is reprinted from materials provided by Fred Hutchinson Cancer Research Center, via Newswise.
      Note: Materials may be edited for content and length. For further information, please contact the source cited above.

      Journal Reference:
      T. M. Brasky, C. Till, E. White, M. L. Neuhouser, X. Song, P. Goodman, I. M. Thompson, I. B. King, D. Albanes, A. R. Kristal. Serum Phospholipid Fatty Acids and Prostate Cancer Risk: Results From the Prostate Cancer Prevention Trial. American Journal of Epidemiology, 2011; 173 (12): 1429 DOI: 10.1093/aje/kwr027

      Source: http://www.sciencedaily.com/releases...Supplements%29
      Comments 8 Comments
      1. sinkheadhxc's Avatar
        sinkheadhxc -
        wow. I dunno how to feel about this.
      1. Vinnyboombots's Avatar
        Vinnyboombots -
        Everything we've ever known is bulls hit Omega 3 is bad for you, vitamins are bad for you, exercise is bad for you.
        Until next week when it becomes good for you again. Lol
      1. rabz's Avatar
        rabz -
        Maybe I miseed it but it would seem like posting what was considered high dose would be helpful.
      1. Clemenza's Avatar
        Clemenza -
        Then how come Japanese men have a much lower risk of prostate cancer than American men? Their diets are shown to consist of much higher levels of omega 3 fatty acids from fish, while the American diet consists of higher amounts of omega 6 acids from meat.

        What were the backgrounds and ethnicities of the men used in this study?

        What type of omega 3 fatty acids and fish oil products were consumed? How pure were they?

        Were there other factors in their diets?

        This reminds me of the that bogus study a few years back saying Vitamin E caused heart disease.

        I don't buy it
      1. Vinnyboombots's Avatar
        Vinnyboombots -
        Originally Posted by Clemenza View Post
        Then how come Japanese men have a much lower risk of prostate cancer than American men?
        Because of Green Tea and Saki.
        Until they say green tea is bad for you!
      1. AT50's Avatar
        AT50 -
        I really more confused now about Omega-3's. I just added it to my TrenA cycle to control my blood pressure. I had an enlarge prostate scare but everything is back to normal. Looks like I'm dumping my fish oil tabs now.
      1. Vinnyboombots's Avatar
        Vinnyboombots -
        Originally Posted by AT50 View Post
        I really more confused now about Omega-3's. I just added it to my TrenA cycle to control my blood pressure. I had an enlarge prostate scare but everything is back to normal. Looks like I'm dumping my fish oil tabs now.
        I wouldn't there's tons of studies and info proving the benefits of fish oil (omega 3) going back decades.
        It would be foolish to stop taking it do to this one article.
      1. Vengeance187's Avatar
        Vengeance187 -
        Originally Posted by Vinnyboombots View Post
        Until they say green tea is bad for you!
        They already have! For hot tea anyway.
        I don't trust the people responsible for this study. Apparently they also did a study that showed trans fats protect against prostate cancer...
        This is a much better article on the study.
        "Within the prostate cancer cases, their plasma phospholipid fatty acid profile was divided into quartiles. The lowest risk group had < 3.68% tissue levels (plasma phospholipids) VS. highest prostate CA risk group being at > 5.3%. This is quite a narrow range of plasma phospholipid fatty acid concentration to draw conclusions from. Moreover, the mean EPA + DPA + DPA fatty acid % in plasma phospholipids was only 4.48% in controls (non-cancer group), and 4.66% in the total cancer case group. Again, an even narrower range from which caution must be taken before drawing sweeping or extreme conclusions and interpretation of this data."

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