Instant Ketosis - AnabolicMinds.com
    • Instant Ketosis



      By Patrick Arnold

      In late 2010 a professor from a university in Florida approached me to see if I could synthesize a compound that he wanted to use in his research. This compound was what is known as a “ketone ester”. This ketone ester is a synthetic prodrug which, after ingestion, your body naturally breaks down into the ketone bodies beta-hydroxybutyrate (BHB) and acetoacetate (AcAc).

      Ketone bodies are energy sources that your body naturally produce and burn under special metabolic conditions. These conditions include starvation and a very high fat / low carbohydrate diet (known as the ketogenic diet). Ketones are the end products of fatty acid metabolism, and compared to your body’s major source of caloric energy (glucose), they are pretty amazing. Unlike glucose, ketones do not require insulin to enter cells and be incorporated into the metabolic cycles that generate the cellular fuel ATP. They cannot be converted to body fat. Also, unlike most fats, ketones can freely enter the brain where they are an excellent fuel for brain cells. On top of all that, ketones generate more ATP per unit oxygen consumed than any other energy source. Ketones are essentially your body’s super fuel.

      I ended up successfully synthesizing this ketone ester for the professor, and he ended up performing some pretty cool studies utilizing the product. For instance in one study he made rats resistant to the toxic effects of high pressure oxygen upon the central nervous system (this has major implications for deep sea divers such as navy seals, as well as indirectly on folks suffering from epilepsy). In another study he almost completely halted the growth of cancerous tumors in rats by giving them the ketone ester. The professor also showed in a more informal study that rats taking the ketone ester could exercise quite a bit longer than control rats.

      As a supplement manufacturer I found the potential health and performance implications for raising ketones through the administration of a “ketone supplement” very exciting. Unfortunately the ketone ester I made for the professor is both synthetic and extremely expensive, so it was wholly unsuitable for sale as a supplement. My collaboration with the professor did get me thinking though, and I set out to see if I could develop a way to raise ketone levels by administering a natural product alternative.

      My focus was on the ketones themselves. As I mentioned previously, there are two major endogenous ketones: beta-hydroxybutyrate (BHB) and acetoacetate (AcAc). AcAc I had to eliminate right off the bat because it is too unstable (it breaks down relatively quickly to acetone and carbon dioxide). BHB on the other hand was a possibility – particularly in the form of one or more of its salts. The problem was the only BHB salt which is commercially available is sodium BHB and it’s just too expensive. So I had to embark on my own R&D project to figure out how to make BHB salts at a price that is not completely out of reach.

      I ended up perfecting a proprietary manufacturing method for sodium and potassium mixed BHB salts. Why mixed sodium and potassium salts? The reason for that is because at the level of intake of BHB required for benefits you would have to ingest a substantial amount of cation (positively charged mineral such as sodium or potassium). At such levels of cation ingestion it made sense that a balance of sodium and potassium salts would be the healthiest thing to do.

      Additionally, I discovered that the product had to be delivered as a concentrated liquid because potassium BHB is simply too hygroscopic to isolate as a powder (it picks up water from the atmosphere and turns into mush at an astonishing rate, whether by itself or mixed with sodium BHB).

      So, just to make things clear, is I have developed a supplement product that raises blood ketone levels. This product does not require a ketogenic diet to raise ketone levels as it is essentially providing an external source of ketones. As such, it will raise ketones even if you eat a plate of spaghetti before taking it (still, its benefits are maximized when combined with either a ketogenic or other sort of low carb diet).

      This kind of thing is a lot of work. For instance it involved developing novel analytical testing methodologies (which as an organic synthesis guy isn’t second nature by any means!) But after about a year of work this weekend I am proud to announce the introduction my sodium and potassium mixed BHB salts on my prototypenutrition.com website.

      https://www.prototypenutrition.com/P...ProductCode=KF

      I hope to continue this topic next week and introduce you to some blood data and exercise performance data on my BHB salts that I think you will find very exciting. Also I will give some tips on how to possibly best uitilize this product for whatever health or fitness goals you may have.

      So stay tuned!

      Source: http://patrickarnoldblog.com/instant-ketosis/
      Comments 16 Comments
      1. fueledpassion's Avatar
        fueledpassion -
        There is already an effective supplement that does this. It's called MCT. In fact, MCT not only causes the liver to produce ketone bodies, but it also wastes tons of energy to do it, making it a double-effective supplement for either lean mass gains or a lypolytic accelerant.
      1. Jakeoh's Avatar
        Jakeoh -
        Originally Posted by fueledpassion View Post
        There is already an effective supplement that does this. It's called MCT. In fact, MCT not only causes the liver to produce ketone bodies, but it also wastes tons of energy to do it, making it a double-effective supplement for either lean mass gains or a lypolytic accelerant.
        The difference of course as you pointed out being that this is an external source of biologically available ketones, versus MCT's being food precursors to ketones and ergo completely irrelevant. That's like saying eating protein is the same as taking in a measured dose of leucine...

        Pat you are the man, always enjoy reading anything you have to say.
      1. Jakeoh's Avatar
        Jakeoh -
        Originally Posted by fueledpassion View Post
        There is already an effective supplement that does this. It's called MCT. In fact, MCT not only causes the liver to produce ketone bodies, but it also wastes tons of energy to do it, making it a double-effective supplement for either lean mass gains or a lypolytic accelerant.
        Also FYI any oil will ultimately produce ketones... ketones are the end result of oil digestion. MCTs and SCTs are just preferable to long chains because of digestion rates. Why would I want my liver to waste its glycogen making ketones from coconut oil when I can takd Pats supp and be taking in energy? Burning energy is lipolytic (el oh el the redundancy here) as you've stated... but that not conducive my mass gains goals, particularly when pats ketones don't require insulin to fuel my muscles...
      1. fueledpassion's Avatar
        fueledpassion -
        Referring to TEF values. 100 kcals of MCT's might equate to only 40 net calories (not a precise number just an estimate).

        MCT's do not require insulin and do not release insulin. Don't know where you got that from. MCT's are small enough to pass through the portal vein and into the liver which performes Krebs cycling. Furthermore, this can be digestedsimultaneously with carbs making it a viable option for adding clean calories to a bulking diet.

        It's a LOT cheaper and increases metabolism greatly while also encouraging fat loss. It prevents muscle-wasting when on low carb diets as well which is ideal for one trying to cut. I dont consider it theory since I've tried it and it works. If you consume 20% of your diet in MCT's, you'll see radical shifts to a more muscular development, even without a heavy presence of carbs.
      1. AdelV's Avatar
        AdelV -
        Great discussion!
      1. Pandabear's Avatar
        Pandabear -
        Originally Posted by fueledpassion View Post
        There is already an effective supplement that does this. It's called MCT. In fact, MCT not only causes the liver to produce ketone bodies, but it also wastes tons of energy to do it, making it a double-effective supplement for either lean mass gains or a lypolytic accelerant.
        You keep beating me to it Fueled :) Still glad you are on these boards mate.
      1. jbryand101b's Avatar
        jbryand101b -
        Hmm, interesting
      1. whitexican911's Avatar
        whitexican911 -
        interesting.. A good read.
      1. JD261985's Avatar
        JD261985 -
        I see TAA has been added to prototype as well. Looks promising.
      1. mrmello's Avatar
        mrmello -
        I was under the impression that all cell in the body can use ketones for fuel BUT brain cells, reason as to why one on a low carb diet has headaches, cannot perform mental tasks well and has mood swings?!
      1. Wocheezy's Avatar
        Wocheezy -
        After keto-adaptation the brain can derive around 80% of its energy from ketones, but it still needs some glucose via diet or gluconeogenesis .
      1. fueledpassion's Avatar
        fueledpassion -
        Originally Posted by Wocheezy View Post
        After keto-adaptation the brain can derive around 80% of its energy from ketones, but it still needs some glucose via diet or gluconeogenesis .
        In doing this, it also converts a much heavier percentage of amino acids into glucose for energy since they readily convert. This is also why BCAA's are essential in any carb or calorie deficient diet.
      1. Jakeoh's Avatar
        Jakeoh -
        Originally Posted by fueledpassion View Post
        Referring to TEF values. 100 kcals of MCT's might equate to only 40 net calories (not a precise number just an estimate).

        MCT's do not require insulin and do not release insulin. Don't know where you got that from. MCT's are small enough to pass through the portal vein and into the liver which performes Krebs cycling. Furthermore, this can be digestedsimultaneously with carbs making it a viable option for adding clean calories to a bulking diet.

        It's a LOT cheaper and increases metabolism greatly while also encouraging fat loss. It prevents muscle-wasting when on low carb diets as well which is ideal for one trying to cut. I dont consider it theory since I've tried it and it works. If you consume 20% of your diet in MCT's, you'll see radical shifts to a more muscular development, even without a heavy presence of carbs.
        Sorry I wasn't knocking MCT oils, I was drawing this parallel- ketone:MCT::HICA:Leucine. Its the end product and ergo doesn't need energy to produce. As far as insulin I meant I can use ketones to fuel skeletal muscles in the ABSENCE of insulin ie sans carbs or as part of carb back loading. Which is excellent because no insulin means glut 4 can pull all the carbs I DO eat straight into my muscles.

        Good thoughts guys
        Cheers
      1. fueledpassion's Avatar
        fueledpassion -
        Originally Posted by Jakeoh View Post
        Sorry I wasn't knocking MCT oils, I was drawing this parallel- ketone:MCT::HICA:Leucine. Its the end product and ergo doesn't need energy to produce. As far as insulin I meant I can use ketones to fuel skeletal muscles in the ABSENCE of insulin ie sans carbs or as part of carb back loading. Which is excellent because no insulin means glut 4 can pull all the carbs I DO eat straight into my muscles.

        Good thoughts guys
        Cheers
        Got it. To understand why I love MCT's is really about three aspects of energy metabolism - Respiratory Quotient (RQ), Food Quotient (FQ) and TEF values.

        MCT's offer a less efficient TEF value than LCF's, which makes them better for keeping a lean body, especially when bulking. Basically, if I shift my macro's towards a less efficient TEF average, then I can still eat a "maintenance level" as before but still burn fat since more calories are released as heat rather than stored as body fat. Even better, I can "cut" without ever activating the homeostatic mechanisms to maintain constant body weight. In a nut shell, MCT's aid in my effort to "trick" my body into painlessly burning fat. Doubly, they also are a good replacement for carbs. So I can have two mechanisms at work to target fat loss without ever making serious cuts to my total calories.

        By cutting calories, your body will resist change in body composition. The more calories you cut, the more pronounced the effort to resist becomes.
      1. Pandabear's Avatar
        Pandabear -
        Originally Posted by mrmello View Post
        I was under the impression that all cell in the body can use ketones for fuel BUT brain cells, reason as to why one on a low carb diet has headaches, cannot perform mental tasks well and has mood swings?!
        Actually mrmello ketogenic diets work much better for your brain and have a protective effect on it. The initial reason keto diets ever came into mainstream is because epileptics that could not be medicated could be put onto a keto diet to prevent seizures. It takes time for the adaption to occur though and high protein is recommended to encourage gluconeogensis too. Do a quick search on pubmed and it will be easy to spot.
      1. fueledpassion's Avatar
        fueledpassion -
        Originally Posted by Pandabear View Post
        Actually mrmello ketogenic diets work much better for your brain and have a protective effect on it. The initial reason keto diets ever came into mainstream is because epileptics that could not be medicated could be put onto a keto diet to prevent seizures. It takes time for the adaption to occur though and high protein is recommended to encourage gluconeogensis too. Do a quick search on pubmed and it will be easy to spot.
        Interestingly Panda, I learned the other day that a diet with 40-50% MCT's reduces seizuresm, lol. Turns out this stuff has medical applications too.

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