• How Much Testosterone Do You Need For Gains

      By Anthony Roberts

      A lot of time is spent on various discussion boards debating the merits of various doses of testosterone. Many experienced users feel that there is a minimum threshold dose required to notice gains in strength and size – and now there’s some scientific support to lend credence to this idea, at least when examining geriatric men. It seems that a testosterone level between 896-1046ng/dl is the minimum amount necessary to realize noticeable gains in lean tissue and strength. Based on some previous research by Bhasin et al., this probably translates to a minimum injectable dose of 200mgs/week of a long estered testosterone. Interestingly, it appears that a lower dose of testosterone can be effective if growth hormone is used concurrently. Clearly this represents a great starting point for Hormone Replacement Therapy.

      So how does this translate to athletes and bodybuilders? It probably gives us a decent minimum starting point for a first cycle, or a viable target to aim for with the use of natural testosterone boosters (supplements).

      J Gerontol A Biol Sci Med Sci. 2011 Jan;66(1):122-9. Epub 2010 Nov 8.

      Testosterone threshold levels and lean tissue mass targets needed to enhance skeletal muscle strength and function: the HORMA trial.

      Sattler F, Bhasin S, He J, Chou CP, Castaneda-Sceppa C, Yarasheski K, Binder E, Schroeder ET, Kawakubo M, Zhang A, Roubenoff R, Azen S.

      Department of Medicine, University of Southern California, 2020 Zonal Avenue, Los Angeles, CA 90033, USA. [email protected]
      In the HORMA (Hormonal Regulators of Muscle and Metabolism in Aging) Trial, supplemental testosterone and recombinant human growth hormone (rhGH) enhanced lean body mass, appendicular skeletal muscle mass, muscle performance, and physical function, but there was substantial interindividual variability in outcomes.

      One hundred and twelve men aged 65-90 years received testosterone gel (5 g/d vs 10 g/d via Leydig cell clamp) and rhGH (0 vs 3 vs 5 μg/kg/d) in a double-masked 2 × 3 factorial design for 16 weeks. Outcomes included lean tissue mass by dual energy x-ray absorptiometry, one-repetition maximum strength, Margaria stair power, and activity questionnaires. We used pathway analysis to determine the relationship between changes in hormone levels, muscle mass, strength, and function.

      Increases in total testosterone of 1046 ng/dL (95% confidence interval = 1040-1051) and 898 ng/dL (95% confidence interval = 892-904) were necessary to achieve median increases in lean body mass of 1.5 kg and appendicular skeletal muscle mass of 0.8 kg, respectively, which were required to significantly enhance one-repetition maximum strength (≥ 30%). Co-treatment with rhGH lowered the testosterone levels (quantified using liquid chromatography-tandem mass spectrometry) necessary to reach these lean mass thresholds. Changes in one-repetition maximum strength were associated with increases in stair climbing power (r = .26, p = .01). Pathway analysis supported the model that changes in testosterone and insulin-like growth factor 1 levels are related to changes in lean body mass needed to enhance muscle performance and physical function. Testosterone’s effects on physical activity were mediated through a different pathway because testosterone directly affected Physical Activity Score of the Elderly.

      To enhance muscle strength and physical function, threshold improvements in lean body mass and appendicular skeletal muscle mass are necessary and these can be achieved by targeting changes in testosterone levels. rhGH augments the effects of testosterone. To maximize functional improvements, the doses of anabolic hormones should be titrated to achieve target blood levels.
      Source: http://www.anthonyroberts.info/2011/...tudy-tells-us/
      Comments 3 Comments
      1. houstontexas's Avatar
        houstontexas -
        Can one conclude from this that test boosters aren't really doing enough to make a difference? What about a product like androlean that claims something like almost 100mg test equivalent? Is that negligible as well?
      1. EasyEJL's Avatar
        EasyEJL -
        No, you have to remember that this is adding muscle and losing fat in the elderly, with no exercise. Its a whole different world for someone who works out, much less is necessary because you actually stimulate the muscles.
      1. houstontexas's Avatar
        houstontexas -
        Originally Posted by EasyEJL View Post
        No, you have to remember that this is adding muscle and losing fat in the elderly, with no exercise. Its a whole different world for someone who works out, much less is necessary because you actually stimulate the muscles.
        Thanks easy
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