Herbal EPO Replacement? - AnabolicMinds.com
    • Herbal EPO Replacement?


      From Ergo-Log

      Any self-respecting endurance athlete no longer even dreams of taking EPO. EPO is sooo 1995. 2012 men and women use stuff like the PPAR-delta-agonist GW501516. Interesting? According to an animal study published in PLoS ONE, there's a supplement that does exactly the same. Have you ever heard of Artemisia iwayomogi?

      Let's refresh our memories. Cells contain the molecule PPAR. PPAR does a thousand and one things, but anabolic bulls in the scientific china shop like us can summarise these into one sentence: PPAR is a fatty acid sensor. The more stimuli a cell receives via PPAR, the more fatty acids it burns. The PPAR variant that's most relevant for muscle cells is PPAR-delta.

      GW501516 is an experimental substance dreamt up in the GlaxoSmithKline labs. If you give it to mice and get them to train you'll notice that GW501516 is an effective endurance drug. [Cell. 2008 Aug 8;134(3):405-15.] So it's no wonder that you can buy GW501516 on the black market.

      Researchers at the Korean AmorePacific Corporation [amorepacific.com] discovered that the concentrated [95 percent] alcohol extract of the plant Artemisia iwayomogi [95EEAI] has the same effect as GW501516. It contains substances that activate the PPAR-delta. The figure below, which is based on in-vitro research, shows this.


      The Koreans fattened mice by giving them food to which extra fat had been added [HFD]. The animals put on weight more quickly than the mice on a normal diet. When the researchers gave HFD mice a daily 200 mg of Artemisia iwayomogi extract per kg bodyweight, then they put on less weight than you’d expect [below left]. Their muscles burned almost twice as much fat as those of the fattened mice that were not given extract [below right].


      Giving Artemisia iwayomogi reduced the growth of fat reserves in the HFD mice [above left]. In addition, the extract boosted the activity in the muscle cells of enzymes that help convert fatty acids into energy [above right].

      Asian traditional healers use Artemisia extracts to treat diabetes. So it's not surprising that the Koreans also discovered that Artemisia iwayomogi boosted the muscle cells' glucose uptake.

      "Our data provide experimental evidence that 95EEAI is a natural PPARdelta agonist that robustly induces genes involved in fatty acid metabolism and activates fatty acid oxidation in vitro and in vivo, suggesting its potential as interventive and preventive measures for the treatment of metabolic disorders", the Koreans summarise.

      We'd just like to add that Artemisia iwayomogi may have other uses, but that will already be clear to you.

      Source:
      PLoS One. 2012;7(3):e33815.

      Source: http://www.ergo-log.com/artemisia-iw...-gw501516.html
      Comments 13 Comments
      1. Torobestia's Avatar
        Torobestia -
        Ingredient in new PES supplement? Lol
      1. monstermash's Avatar
        monstermash -
        ^^ was thinking the same thing. this or SPP's cardiotryx?
      1. monstermash's Avatar
        monstermash -
        for our sake i hope it is.
      1. Torobestia's Avatar
        Torobestia -
        Originally Posted by monstermash View Post
        for our sake i hope it is.
        As long as it works, though. GW, for instance, clearly was something that was good on paper but failed miserably when people tried to take it.
      1. monstermash's Avatar
        monstermash -
        Originally Posted by Torobestia View Post
        As long as it works, though. GW, for instance, clearly was something that was good on paper but failed miserably when people tried to take it.
        True that. Never messed with the stuff but who knows if what people were buying was actual GW...
      1. Vipersg123's Avatar
        Vipersg123 -
        sure hope someone gets on this, i want some!
      1. Torobestia's Avatar
        Torobestia -
        Originally Posted by monstermash View Post
        True that. Never messed with the stuff but who knows if what people were buying was actual GW...
        A fair retort
      1. shaolin2112's Avatar
        shaolin2112 -
        just getting back into the industry after about a 10 year layoff. where can i get this? i've searched every where.
      1. D3Baseball's Avatar
        D3Baseball -
        In vitro data people. Someone will have to show oral availability before folks put it in supplements.
      1. prld2gr8ns's Avatar
        prld2gr8ns -
        Originally Posted by D3Baseball View Post
        In vitro data people. Someone will have to show oral availability before folks put it in supplements.
        The article shows both. In vitro data is referencing kinetics of PPAR activation. In vivo showing results with specific dosage.

        "The Koreans fattened mice by giving them food to which extra fat had been added [HFD]. The animals put on weight more quickly than the mice on a normal diet. When the researchers gave HFD mice a daily 200 mg of Artemisia iwayomogi extract per kg bodyweight, then they put on less weight than you’d expect [below left]. Their muscles burned almost twice as much fat as those of the fattened mice that were not given extract [below right]."
      1. D3Baseball's Avatar
        D3Baseball -
        Originally Posted by prld2gr8ns View Post
        The article shows both. In vitro data is referencing kinetics of PPAR activation. In vivo showing results with specific dosage.

        "The Koreans fattened mice by giving them food to which extra fat had been added [HFD]. The animals put on weight more quickly than the mice on a normal diet. When the researchers gave HFD mice a daily 200 mg of Artemisia iwayomogi extract per kg bodyweight, then they put on less weight than you’d expect [below left]. Their muscles burned almost twice as much fat as those of the fattened mice that were not given extract [below right]."
        Good catch!
      1. Torobestia's Avatar
        Torobestia -
        So for a person like me I get around 340mg. That's not an unfeasible number.
      1. RiZzah's Avatar
        RiZzah -
        So this is how Bradley Wiggins is going to win the Tour De France!

        Knew it! ;)