• DNA Protected By Calorie Restriction


      From Science Daily

      One of the indicators of a cell's health is the state of its DNA and containers -- the chromosomes -- so when these fuse together or suffer anomalies, they can become the source of illnesses like cancer and/or aging processes.

      According to a study carried out by a team led by María Blasco, the director of the Spanish National Cancer Research Centre (CNIO) and head of the Telomeres and Telomerase Group, a sustained lowering of food intake over time results in an increase of telomere length -- the ends of chromosomes -- in adult mice, which has a protective effect on the DNA and genetic material.

      These beneficial effects on the youth of the chromosomes translate to a lower incidence of cancer and other age-related illnesses. The journal PLOS ONE is to publish the details of this study in its online edition this week.

      A lower incidence of cancer and better health

      To carry out the study, researchers used young mice -- just three months old -- and reduced their caloric intake by 40% before observing them until the end of their life cycle.

      "We see that mice that undergo caloric restriction show a lower telomere shortening rate than those fed with a normal diet," says Blasco. "These mice therefore have longer telomeres as adults, as well as lower rates of chromosome anomalies," she adds.

      To study the effects of this phenomenon on the health of the mammals, researchers observed the incidence of age-related illnesses like cancer. The mice that had been fed a lower calorie intake showed a reduction in the incidence of cancer.

      Furthermore, these mice also showed a lower incidence of other age-related illnesses such as osteoporosis, greater glucose uptake or improvements in motor coordination.
      When the researchers carried out these same experiments with a variety of mice that produce more telomerase -- a protein that lengthens telomeres and protects chromosomes -- they observed that these mice not only enjoyed better health but also lived up to 20% longer.

      "We believe that such a significant increase in longevity is due to the protective effect against cancer produced by caloric restriction -- incidents fall by 40% if we compare them with the mice that produce more telomerase and have a normal diet -- and, added to the presence of longer telomeres, this makes the mice live longer and better," says Blasco.

      Despite the effects of caloric restriction depending on the genetic characteristics of each organism, this study opens the way to studying the effect other factors and lifestyle habits, such as smoking or exercise, might have on aging.

      Furthermore, it is calculated that there are currently more than 10,000 people in the world on some form of controlled caloric restriction, so the observation of these individuals will be decisive in discovering the effects of this type of diet on humans.

      Story Source:
      The above story is reprinted from materials provided by Centro Nacional de Investigaciones Oncologicas (CNIO), via EurekAlert!, a service of AAAS.
      Note: Materials may be edited for content and length. For further information, please contact the source cited above.

      Journal Reference:
      Elsa Vera, Bruno Bernardes de Jesus, Miguel Foronda, Juana M. Flores, Maria A. Blasco. Telomerase Reverse Transcriptase Synergizes with Calorie Restriction to Increase Health Span and Extend Mouse Longevity. PLoS ONE, 2013; 8 (1): e53760 DOI: 10.1371/journal.pone.0053760

      Source:
      Comments 8 Comments
      1. MANotaur's Avatar
        MANotaur -
        so im boiling this down....

        fewer calories=less degregdation of the telomeres=healthier aging=lowered risk for cancer=i die older=i look younger when I die...

        now how does reducing calories enduce these benefits??

        or is it true cause science daily says so?
      1. 1ifeblood's Avatar
        1ifeblood -
        I think mental and emotional wellness plays a big role in longevity as well...something that mice don't have to worry about. I'm all for living longer and healthier, I just don't see how taking in fewer calories will assist in that. Now exercise, proper diet, happy love life/family, spiritual growth (in whatever beliefs you hold), staying active, and an overall acceptance of self and purpose...I think these make up the important ingredients to a longer, healthier life. But that's just my opinion...I don't have any science to back it up.
      1. MANotaur's Avatar
        MANotaur -
        lifeblood...is your chest hair waxed into the batwings??
      1. 1ifeblood's Avatar
        1ifeblood -
        Originally Posted by MANotaur View Post
        lifeblood...is your chest hair waxed into the batwings??
        lol...It's actually a raven (my oldest daughter's name) with a drop shadow. Hard to see the detail in that pic! But no it's not waxed...just shaved. :-)
      1. MANotaur's Avatar
        MANotaur -
        oh ok lol. i was thinkin dude...super fan lol
      1. EatMoar's Avatar
        EatMoar -
        Ill still continue to eat my surplus thank you very much science daily.
      1. fightbackhxc's Avatar
        fightbackhxc -
        If you can increase the length and longevity of telomeres then it actually does help the health of your cells. A telomere shortens each time a damaged cell replicates. The telomere acts as sort of a repair agent for these damaged cells. Once the telomere can No longer repair the cell...you start replicating damaged cells. At least this is my understanding.
      1. 1ifeblood's Avatar
        1ifeblood -
        Originally Posted by fightbackhxc View Post
        If you can increase the length and longevity of telomeres then it actually does help the health of your cells. A telomere shortens each time a damaged cell replicates. The telomere acts as sort of a repair agent for these damaged cells. Once the telomere can No longer repair the cell...you start replicating damaged cells. At least this is my understanding.
        So what we need is telomere supplementation...when they gonna start making THAT?

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