DMAA NOT Found In Geranium - AnabolicMinds.com
    • DMAA NOT Found In Geranium


      By Stephen DANIELLS Nutra Ingredients USA

      Controversial ingredient DMAA is not detectable in plant material and oil from geranium (Pelargonium graveolens), says a new analysis that has been hailed as the ‘final coffin nail in the long suffering DMAA debate’.

      In a ‘comprehensive’ and ‘robust’ analysis published in the Journal of Analytical Toxicology on Monday, scientists report that gas chromatography–mass spectrometry (GC-MS) and liquid chromatography–tandem mass spectrometry (LC–MS-MS) analysis of geranium oils or young and mature, fresh and dried leaves and stems found no detectable levels of DMAA (1,3-Dimethylamylamine, also known as methyl hexaneamine (MHA), and several other names).

      The scientists further confirmed the results using liquid chromatography–high-resolution mass spectrometry (high resolution LC–QTOF-MS).

      Commercial products

      The scientists then took the step of subjecting three commercial - but unnamed - supplements containing DMAA/MHA to the same analytical procedures, and concluded: “The dietary supplements that contained MHA as one of their ingredients (allegedly from geranium or geranium stems) contained large amounts of MHA.

      “The amounts of MHA measured are incompatible with the use of reasonable amounts of P. graveolens extract or concentrate, suggesting that MHA was of synthetic origin.”

      The new analysis was performed by scientists from ElSohly Laboratories, Inc. (ELI), Phyto Chemical Services, Inc. (PSI), the National Center for Natural Products Research, The University of Mississippi, and the US Anti- Doping Agency (USADA).

      The issue

      MHA/DMAA has rarely been out of the headlines in recent months since FDA issued warning letters to 10 manufacturers and distributors of supplements containing DMAA.

      There has been intense debate about whether DMAA, which was first manufactured synthetically by drug giant Eli Lily in the 1940s, is in fact a constituent of geranium.

      According to a single analysis by Chinese researchers reportedly using gas chromatography-mass spectrometry (GC-MS) techniques and published in the Journal of Guizhou Institute of Technology (1996, Vol. 25, pp. 82-85) – ‘The Ping Paper’ – DMAA is a constituent of geranium oil, but no other published analysis has reported its presence.

      ‘Very good work performed by a reputable team of scientists’

      Commenting independently on the new analysis, James Neal-Kababick, Director of Flora Research Laboratories, told NutraIngredients-USA that the paper “comprehensively puts the final coffin nail in the long suffering DMAA debate .

      “The researchers have comprehensively addressed the issues of analysis, accounted for numerous variables and once again, like so many other recent publications have shown using no less than three separate analytical approaches that methylhexaneamine is not found in any geranium plant material or essential oil tested by their group.

      “Unlike several other researchers, this group was sure to include authenticated plant materials in their study. This is an often overlooked step in investigating natural products and is a critical step in assuring accurate data is reported.

      “Finally, the theoretical calculations based on various hypothetical DMAA yields reported indicates just how ridiculous the whole geranium sourced DMAA argument is. Considering how much material was utilized in the dietary supplements industry, we would be up to armpits in spent geranium marc if DMAA was actually being isolated from geranium sources at any of the claimed levels in publication including the Ping paper which I have long considered to be erroneous.

      “This is very good work performed by a reputable team of scientists which supports the position I have argued for so long: DMAA is not found in geranium or geranium essential oil as a naturally occurring product,” said Kababick.

      Robust results

      Mark Blumenthal, founder & executive director of the American Botanical Council (ABC), welcomed the publication of the paper, having already heard a preliminary presentation of the findings by Prof. Mahmoud ElShohly at the Annual Oxford Conference on the Science of Botanicals at Ole Miss in April.

      “In this paper, the researchers employed several analytical methods to help ensure the appropriateness and robustness of their results,” said Blumenthal.

      “In addition, they analyzed various types of Pelargonium graveolens materals -- e.g., commercial essential oils, authenticated oils, and botanically vouchered pelargonium leaves in various states (fresh and dried), etc. -- in order to increase the confidence level of their results as they would apply to the current controversy regarding whether DMAA (aka MHA) is detectable as a naturally-occurring phytochemical in Pelargonium graveolens leaves, as some marketers have claimed for the past few years.

      “This highly accurate and robust analysis found no detectable levels of DMAA (MHA), at the highly-sensitive level of 10 parts per billion.”

      “ABC has stated repeatedly that we have not seen any credible, published scientific evidence that DMAA (MHA) is found or detectable in Pelargonium graveolens,” Blumenthal continued.

      “The results of this new analysis further strengthens ABC's previously-stated position. It may be seen as another nail — a big one — in the coffin of the DMAA-from-plants claims controversy.”

      A spokesperson for FDA told this website that the analysis had not weighed into FDA’s decision to take action.

      Source: Journal of Analytical Toxicology
      Published online ahead of print, doi:10.1093/jat/bks055
      “Pelargonium Oil and Methyl Hexaneamine (MHA): Analytical Approaches Supporting the Absence of MHA in Authenticated Pelargonium graveolens Plant Material and Oil”
      Authors: M.A. ElSohly, W. Gul, K.M. ElSohly, T.P. Murphy, A. Weerasooriya, A.G. Chittiboyina, B. Avula, I. Khan, A. Eichner, L.D. Bowers

      Source: http://www.nutraingredients-usa.com/...%2BText%2BNews
      Comments 8 Comments
      1. stevenbrianp's Avatar
        stevenbrianp -
        I know I have been worried that DMAA would be deemed illegal lately, but what is the significance if it had in fact been found in Geranium?
      1. pjhom's Avatar
        pjhom -
        Originally Posted by stevenbrianp View Post
        I know I have been worried that DMAA would be deemed illegal lately, but what is the significance if it had in fact been found in Geranium?
        I think it is because Neurocore and several other PWO's use geranium oil instead of DMAA and were not put on the "no-fly list".
      1. rkinnee09's Avatar
        rkinnee09 -
        So should I continue to stock up on DMAA or no?
      1. Gat0rbait's Avatar
        Gat0rbait -
        Well then companies could say look see this is natural and should be allowed. But this pretty much proves it was synthetic which cannot be marketed as a dietary supplement from my understanding.
      1. dpagli's Avatar
        dpagli -
        Originally Posted by Gat0rbait View Post
        Well then companies could say look see this is natural and should be allowed. But this pretty much proves it was synthetic which cannot be marketed as a dietary supplement from my understanding.
        The argument can still be made that the language of the DSHEA does not rule out synthetic creation of raw sourcing. The conversation is all wrong anyway, nobody cares if it is from plant or not; can it be proven dangerous?

        The answer is simple, no hell no it can not be proven.
      1. GrizzlyLB50's Avatar
        GrizzlyLB50 -
        Originally Posted by dpagli View Post

        The argument can still be made that the language of the DSHEA does not rule out synthetic creation of raw sourcing. The conversation is all wrong anyway, nobody cares if it is from plant or not; can it be proven dangerous?

        The answer is simple, no hell no it can not be proven.
        The issue is that it was originally discovered from the oil and plant in a different form which was much less potent as an alpha-1 activator, the synthetic form (which is not found naturally in the distillation) is 200 times more effective and hasn't been thoroughly studied in humans. Thus the issue and concern is valid due to it not being covered by the herbal rules ( it's synthetic) it was necessary to under go testing as a new drug. The companies never submitted it for testing. That's why there was a cease order issued.
      1. GrizzlyLB50's Avatar
        GrizzlyLB50 -
        double post due to poor mobile connection
      1. dpagli's Avatar
        dpagli -
        Originally Posted by GrizzlyLB50 View Post
        double post due to poor mobile connection
        Funny how the NDI rules only apply when it fits the FDA agenda. DMAA is not dangerous nor does it test positive on 4-6 panel tests for amphetamines under any circumstances. I have 45 panel tests taken under the effects of 14 different DMAA products and none tested positive.

        FYI - the FDA has been forced back to the drawing board on the NDI and is under review for enforced actions based on these rules that are not even law yet. Anyone defending the FDA and their actions over the last few years is clearly on their payroll.

        Using the no NDI submitted argument here is amusing, please lets proceed in pulling the other 10,000 products that have been released since 1994 and are not on thr preexisting list and have no NDI processed. Yea pointing at every major supplements mfg in the US.

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