• Disrupted Sleep Leads To Obesity, Diabetes

      From ScienceDaily

      A study by researchers at Brigham and Women's Hospital (BWH) reinforces the finding that too little sleep or sleep patterns that are inconsistent with our body's "internal biological clock" may lead to increased risk of diabetes and obesity. This finding has been seen in short-term lab studies and when observing human subjects via epidemiological studies. However, unlike epidemiological studies, this new study provides support by examining humans in a controlled lab environment over a prolonged period, and altering the timing of sleep, mimicking shift work or recurrent jet lag.

      The study will be electronically published on April 11, 2012 in Science Translational Medicine.

      Researchers hosted 21 healthy participants in a completely controlled environment for nearly six weeks. The researchers controlled how many hours of sleep participants got, as well as when they slept, and other factors such as activities and diet. Participants started with getting optimal sleep (approximately 10 hours per night). This was followed by three weeks of 5.6 hours of sleep per 24-hour period and with sleep occurring at all times of day and night, thereby simulating the schedule of rotating shift workers. Thus, during this period, there were many days when participants were trying to sleep at unusual times within their internal circadian cycle-the body's "internal biological clock" that regulates sleep-wake and many other processes within our bodies. The study closed with the participants having nine nights of recovery sleep at the usual time.

      The researchers saw that prolonged sleep restriction with simultaneous circadian disruption decreased the participants' resting metabolic rate. Moreover, during this period, glucose concentrations in the blood increased after meals, because of poor insulin secretion by the pancreas.

      According to the researchers, a decreased resting metabolic rate could translate into a yearly weight gain of over 10 pounds if diet and activity are unchanged. Increased glucose concentration and poor insulin secretion could lead to an increased risk for diabetes.

      "We think these results support the findings from studies showing that, in people with a pre-diabetic condition, shift workers who stay awake at night are much more likely to progress to full-on diabetes than day workers," said Orfeu M. Buxton, PhD, BWH neuroscientist and lead study author. "Since night workers often have a hard time sleeping during the day, they can face both circadian disruption working at night and insufficient sleep during the day. The evidence is clear that getting enough sleep is important for health, and that sleep should be at night for best effect."

      This research was supported by the National Institute on Aging; National Heart, Lung and Blood Institute; National Center for Research Resources; Center for Clinical Investigation of the Harvard Clinical and Translational Science Center; Joslin Diabetes and Endocrinology Research Center Service Specialized Assay Core; the National Space Biomedical Research Institute; and Natural Sciences and Engineering Research Council of Canada.

      Story Source:
      The above story is reprinted from materials provided by Brigham and Women's Hospital.
      Note: Materials may be edited for content and length. For further information, please contact the source cited above.

      Journal Reference:
      O. M. Buxton, S. W. Cain, S. P. O'Connor, J. H. Porter, J. F. Duffy, W. Wang, C. A. Czeisler, S. A. Shea. Adverse Metabolic Consequences in Humans of Prolonged Sleep Restriction Combined with Circadian Disruption. Science Translational Medicine, 2012; 4 (129): 129ra43 DOI: 10.1126/scitranslmed.3003200

      Source: http://www.sciencedaily.com/releases...0411144316.htm
      Comments 6 Comments
      1. OrganicShadow's Avatar
        OrganicShadow -
        Ten hours of sleep optimal? Yeah, right.
      1. sweatymoo's Avatar
        sweatymoo -
        I'm lucky if I get five solid hours a night... I'm type 2, could I sue my kids for lack of sleep
      1. TheHardOne's Avatar
        TheHardOne -
        3-4 hours for me

        Come at me!
      1. wtmdcg91's Avatar
        wtmdcg91 -
        Ahhhhhh i wish things could work ideally ... but no **** they don't so goes for sleep . Some people have no choice but work at night , anyway i love all these test and findings give us solutions and not what we already know!
      1. OrganicShadow's Avatar
        OrganicShadow -
        Between 6-7 is my magic number. Anything more and Im groggy, plus im too hungry to sleep that long. As men age they need less and less sleep to function to full capacity. Only toddlers need 10 hours.

        I believe that if you can fully simulate night and day while working of shifts (I did) you can redesign your circadian cycle. It takes a while but its really about changing when you produce melatonin and not fully relying on supplementation. The body will only release melatonin in complete darkness. So when you enter REM and the cones in the retina no long sense light intensity the body starts producing melatonin.
      1. CopyCat's Avatar
        CopyCat -
        The optimal amount of sleep for an individual will vary from person to person. 10hrs may be optimal for some, but not others. In their opening paragraph they say or go against the bodies internal clock. That's what you should be listening to.
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