• Circadian Desynchrony And Obesity


      From ScienceDaily

      When Thomas Edison tested the first light bulb in 1879, he could never have imagined that his invention could one day contribute to a global obesity epidemic. Electric light allows us to work, rest and play at all hours of the day, and a paper published this week in Bioessays suggests that this might have serious consequences for our health and for our waistlines.

      Daily or "circadian" rhythms including the sleep wake cycle, and rhythms in hormone release are controlled by a molecular clock that is present in every cell of the human body. This human clock has its own inbuilt, default rhythm of almost exactly 24 hours that allows it to stay finely tuned to the daily cycle generated by the rotation of Earth. This beautiful symmetry between the human clock and the daily cycle of Earth's rotation is disrupted by exposure to artificial light cycles, and by irregular meal, work and sleep times. This mismatch between the natural circadian rhythms of our bodies and the environment is called "circadian desynchrony."

      The paper, by Dr. Cathy Wyse, working in the chronobiology research group at the University of Aberdeen, focuses on how the human clock struggles to stay in tune with the irregular meal, sleep and work schedules of the developed world, and how this might influence health and even cause obesity.

      "Electric light allowed humans to override an ancient synchronization between the rhythm of the human clock and the environment, and over the last century, daily rhythms in meal, sleep and working times have gradually disappeared from our lives," said Wyse. "The human clock struggles to remain tuned to our highly irregular lifestyles, and I believe that this causes metabolic and other health problems, and makes us more likely to become obese."

      "Studies in microbes, plants and animals have shown that synchronization of the internal clock with environmental rhythms is important for health and survival, and it is highly likely that this is true in humans as well."

      The human clock is controlled by our genes, and the research also suggests that some people may be more at risk of the effects of circadian desynchrony than others. For example, humans originating from Equatorial regions may have clocks that are very regular, which might be more sensitive to the effects of circadian desynchrony.

      Shiftwork, artificial light and the 24-hour lifestyle of the developed world mean that circadian desynchrony is now an inevitable part of 21st century life. Nevertheless, we can help to maintain healthy circadian rhythms by keeping regular meal times, uninterrupted night-time sleep in complete darkness, and by getting plenty of sunlight during daylight hours.

      Dr. Wyse believes that circadian desynchrony affects human health by disrupting the systems in the brain that regulate metabolism, leading to an increased likelihood of developing obesity and diabetes.

      "The reason for the relatively sudden increase in global obesity in the developed world seems to be more complicated than simply just diet and physical activity. There are other factors involved, and circadian desynchrony is one that deserves further attention."

      "Our 24-hour society has come at the high price of circadian desynchrony," concluded Wyse. "There are many factors driving mankind towards obesity but disrupted circadian rhythms should be considered alongside the usual suspects of diet and exercise."

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      Source: http://www.sciencedaily.com/releases...Weight+Loss%29
      Comments 3 Comments
      1. jalfrey's Avatar
        jalfrey -
        I worked third shift for any couple of years and gained 35lbs despite exercise. Part of my problem was that I had to eat to stay awake many nights. I blame that on circadian desychrony! Btw, the weight is off now;-)
      1. wtmdcg91's Avatar
        wtmdcg91 -
        Great and true read!! There are many factors that play roll in been overweight or obese!
      1. eluruguayo's Avatar
        eluruguayo -
        I have found it easier to stay lean and healthy working third-shift (I sleep from 8am to 3pm). Disclaimer: That is the time of day when I naturally sleep if I have zero caffeine, etc. (since the age of seven!), so your mileage may vary.

        The biggest difference I've found is that, when it's dark outside, I simply don't get the same degree of hunger that I get when it's daylight outside.
        My maintenance level is about 2,600 calories. If I have to get up early and be awake during all the daylight hours -- even on the same amount of sleep -- I find it almost impossible to consume less than 2,500 calories before the sun has even gone down, with, of course, more to follow. It's like a nonstop carnival of hunger as long as the sun is out, and by the time the day is over I've usually shoveled in 3,500+ calories even if I am slamming the vegetables all day long.
        By contrast, if I am on my usual daily schedule (wake at 3pm, sleep at 8am), I can eat 700 to 900 calories at breakfast, eat almost nothing again until 2-3 hours before going to sleep (unless I work out), and stay at about 2,000 calories for the whole day, without the slightest hint of hunger.

        If I were forced back onto a "normal" day, I have no doubt that I would balloon back up to my previous weight, about 30 kgs heavier than my current weight, within a few months.

        jalfrey:
        Part of my problem was that I had to eat to stay awake many nights.
        Really?

        Food makes me sleepy, not alert. If I am sleep-deprived, I have to eat less, or else I'll crash.

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