• Can Resveratrol LOWER The Effects Of Exercise?

      From Science Daily

      In older men, a natural antioxidant compound found in red grapes and other plants – called resveratrol – blocks many of the cardiovascular benefits of exercise, according to research published July 22 in The Journal of Physiology.

      Resveratrol has received widespread attention as a possible anti-aging compound and is now widely available as a dietary supplement; much has been made of its role in explaining the cardiovascular health benefits of red wine, and other foods. But now, new research at The University of Copenhagen surprisingly suggests that eating a diet rich in antioxidants may actually counteract many of the health benefits of exercise, including reduced blood pressure and cholesterol.

      In contrast to earlier studies in animals in which resveratrol improved the cardiovascular benefits of exercise, this study in humans has provided surprising and strong evidence that in older men, resveratrol has the opposite effect.

      What is emerging is a new view that antioxidants are not a fix for everything, and that some degree of oxidant stress may be necessary for the body to work correctly. This pivotal study suggests that reactive oxygen species, generally thought of as causing aging and disease, may be a necessary signal that causes healthy adaptations in response to stresses like exercise. So too much of a good thing (like antioxidants in the diet) may actually be detrimental to our health.
      Lasse Gliemann, a PhD student who worked on the study at The University of Copenhagen, explains how they conducted the research, and the results they found: “We studied 27 healthy, physically inactive men around 65 years old for 8 weeks. During the 8 weeks all of the men performed high-intensity exercise training and half of the group received 250 mg of resveratrol daily, whereas the other group received a placebo pill (a pill containing no active ingredient). The study design was double-blinded, thus neither the subjects nor the investigators knew which participant that received either resveratrol or placebo.

      “We found that exercise training was highly effective in improving cardiovascular health parameters, but resveratrol supplementation attenuated the positive effects of training on several parameters including blood pressure, plasma lipid concentrations and maximal oxygen uptake.”

      Ylva Hellsten, the leader of the project, says: “We were surprised to find that resveratrol supplementation in aged men blunts the positive effects of exercise training on cardiovascular health parameters, in part because our results contradict findings in animal studies.

      “It should be noted that the quantities of resveratrol given in our research study are much higher than what could be obtained by intake of natural foods.”

      This research adds to the growing body of evidence questioning the positive effects of antioxidant supplementation in humans.

      Michael Joyner, from The Mayo Clinic USA, says how the study has wider implications for research: “In addition to the surprising findings on exercise and resveratrol, this study shows the continuing need for mechanistic studies in humans. Too often human studies focus on large scale outcomes and clinical trials and not on understanding the basic biology of how we adapt.”

      Story Source:
      The above story is reprinted from materials provided by Wiley, via AlphaGalileo.
      Note: Materials may be edited for content and length. For further information, please contact the source cited above.

      Journal Reference:
      Lasse Gliemann, Jakob Friis Schmidt, Jesper Olesen, Rasmus Sjørup Biensø, Sebastian Louis Peronard, Simon Udsen Grandjean, Stefan Peter Mortensen, Michael Nyberg, Jens Bangsbo, Henriette Pilegaard, and Ylva Hellsten. Resveratrol Blunts the Positive Effects of Exercise Training on Cardiovascular Health in Aged Men. JPHYSIOL,

      Source: http://www.sciencedaily.com/releases...Weight+Loss%29
      Comments 5 Comments
      1. Lagartizscha's Avatar
        Lagartizscha -
        Soon they will find out tht drinking water has opposite effects to health.
      1. mtinsideout's Avatar
        mtinsideout -
        I wonder what doses they were using in the study.
      1. mtinsideout's Avatar
        mtinsideout -
        Never mind i skipped the part that says 250mg a day for 8 weeks
      1. AdonisBelt's Avatar
        AdonisBelt -
        250mg is a ridiculously low dose compared to the typical dose of 1-2g used in studies like this... There has been some research suggesting resveratrol has the capability of interfering with the mTor metabolic pathway so I suppose there is some plausibility that some effects are negated in older previously inactive men... But I'm not sure i buy it. I would like to have seen this done while their nutrition was actually controlled and resistance training was involved.
      1. Aj2000's Avatar
        Aj2000 -
        Your correct res does affect mtor by stimulating PPAR it's a timing game with this supp and you gotta know your stuff

        Res is great for fitness but not at that level, you would get no benefit but you would affect the mtor pathway so even less benefits
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