Aromatase Inhibitors Grow Muscle In Women - AnabolicMinds.com
    • Aromatase Inhibitors Grow Muscle In Women



      From Ergo Log

      Men show little change in body composition if you block their estradiol production with the enzyme aromatase. [Clin Endocrinol (Oxf). 2008 Jun 25. [Epub ahead of print].] In women things are different, oncologists at the University of Pittsburgh in the US discovered. Aromatase inhibitors boost muscle mass in the fair sex.

      Let's start with a recap: there are two sorts of anti-oestrogens. First of all there are SERMs, like tamoxifen and clomiphene. These block the estradiol receptors and thus prevent estradiol from doing its work. They often actually take over some of the functions of estradiol. In men SERMS raise testosterone levels; in women they don't.

      And then there are the aromatase inhibitors like anastrozole [structural formula shown above]. These interfere with the functioning of the enzyme aromatase as a result of which less androstenedione and testosterone are converted into estradiol.

      Chemical athletes use anti-oestrogens to counteract the side effects of some anabolic steroids, but also to restore the body's own testosterone production after taking a course of steroids. Doctors subscribe the same anti-oestrogens for breast cancer survivors, as they reduce the chance of the cancer returning.

      Tamoxifen
      Doctors have collected a lot of information on the side effects of SERMS, in particular those of tamoxifen. Long-term use of tamoxifen [structural formula on the right] leads to negative changes in body composition. Women often lose muscle mass and build up fat.

      Not much is yet known about the side effects of aromatase inhibitors.

      Letrozole
      For example, what is the effect of aromatase inhibitors on women's body composition? This is the question that the researchers set out to answer in the small study they did of 82 women, who they monitored over a period of two years.

      The women were all cancer survivors. Half of them were given a SERM – usually tamoxifen, but sometimes also toremifene or fulvestrant [no-AIs]. The other half were given an aromatase inhibitor, such as letrozole [structural formula shown here], anastrazole or exemestane [AIs].

      During the 24 months that the study lasted the fat mass of the women who took SERMs increased by a kilogram, while there was no increase in fat mass in those who took an aromatase inhibitor.

      SERMs had no effect on lean body mass, while the aromatase inhibitors led to more than a kilogram increase in lean body mass.





      The aromatase inhibitors increased the amount of testosterone in the blood, and the researchers think that this was the reason for the increase in the women's lean body mass.

      Exemestane
      We, the nit-picking compilers of this web magazine, have a teeny problem with this study: the researchers do not reveal how many of the women in the AI group were given exemestane [structural formula on the right]. Moreover, we wonder whether the miraculous effects of the aromatase inhibitors would still be observed if the exemestane had been excluded from the study.

      Exemestane is not just an aromatase inhibitor: it's also an androgen with an anabolic effect. Exemestane is an anabolic steroid.

      Source:
      PLoS One. 2014 Jan 29;9(1):e85805.

      Source: http://www.ergo-log.com/aromatase-in...scle-mass.html
      Comments 5 Comments
      1. Quadzilla99's Avatar
        Quadzilla99 -
        Dat main photo...hnnggg
      1. Type O Hero's Avatar
        Type O Hero -
        Originally Posted by The Press View Post
        <img src="http://anabolicminds.com/forum/attachment.php?attachmentid=98 782"/>

        From Ergo Log

        Men show little change in body composition if you block their estradiol production with the enzyme aromatase. [Clin Endocrinol (Oxf). 2008 Jun 25. [Epub ahead of print].] In women things are different, oncologists at the University of Pittsburgh in the US discovered. Aromatase inhibitors boost muscle mass in the fair sex.

        Let's start with a recap: there are two sorts of anti-oestrogens. First of all there are SERMs, like tamoxifen and clomiphene. These block the estradiol receptors and thus prevent estradiol from doing its work. They often actually take over some of the functions of estradiol. In men SERMS raise testosterone levels; in women they don't.

        And then there are the aromatase inhibitors like anastrozole [structural formula shown above]. These interfere with the functioning of the enzyme aromatase as a result of which less androstenedione and testosterone are converted into estradiol.

        Chemical athletes use anti-oestrogens to counteract the side effects of some anabolic steroids, but also to restore the body's own testosterone production after taking a course of steroids. Doctors subscribe the same anti-oestrogens for breast cancer survivors, as they reduce the chance of the cancer returning.

        Tamoxifen
        Doctors have collected a lot of information on the side effects of SERMS, in particular those of tamoxifen. Long-term use of tamoxifen [structural formula on the right] leads to negative changes in body composition. Women often lose muscle mass and build up fat.

        Not much is yet known about the side effects of aromatase inhibitors.

        Letrozole
        For example, what is the effect of aromatase inhibitors on women's body composition? This is the question that the researchers set out to answer in the small study they did of 82 women, who they monitored over a period of two years.

        The women were all cancer survivors. Half of them were given a SERM – usually tamoxifen, but sometimes also toremifene or fulvestrant [no-AIs]. The other half were given an aromatase inhibitor, such as letrozole [structural formula shown here], anastrazole or exemestane [AIs].

        During the 24 months that the study lasted the fat mass of the women who took SERMs increased by a kilogram, while there was no increase in fat mass in those who took an aromatase inhibitor.

        SERMs had no effect on lean body mass, while the aromatase inhibitors led to more than a kilogram increase in lean body mass.

        <img src="http://anabolicminds.com/forum/attachment.php?attachmentid=98 781"/>

        <img src="http://anabolicminds.com/forum/attachment.php?attachmentid=98 780"/>

        The aromatase inhibitors increased the amount of testosterone in the blood, and the researchers think that this was the reason for the increase in the women's lean body mass.

        Exemestane
        We, the nit-picking compilers of this web magazine, have a teeny problem with this study: the researchers do not reveal how many of the women in the AI group were given exemestane [structural formula on the right]. Moreover, we wonder whether the miraculous effects of the aromatase inhibitors would still be observed if the exemestane had been excluded from the study.

        Exemestane is not just an aromatase inhibitor: it's also an androgen with an anabolic effect. Exemestane is an anabolic steroid.

        Source:
        PLoS One. 2014 Jan 29;9(1):e85805.

        Source: http://www.ergo-log.com/aromatase-in...scle-mass.html
        First sentence of article is crap.
      1. JD261985's Avatar
        JD261985 -
        Originally Posted by Type O Hero View Post
        First sentence of article is crap.
        Yea that confused me a little bit..
      1. UCSMiami's Avatar
        UCSMiami -
        I cannot get beyond the pic. We never have women like that in our gym.
      1. mrmello's Avatar
        mrmello -
        I found myself scrolling back to the top several times during reading.. in fact I couldn´t get past the Letrozole part.. who is this girl geez just perfect!

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