"Cooper Approved Stack?" You guys insisted...Apply now!

Page 1 of 10 123 ... Last
  1. Thumbs up "Cooper Approved Stack?" You guys insisted...Apply now!

    EBF and PES team up to make burning fat even hotter:

    This is a log for…
    EBF: Adipose Annihilation V2
    PES: Alphamine

    Get those apps in. Looking for experienced, detailed loggers. US only!

    To completely round out your fat burning arsenal we have both pre and post meal catalysts for fat burning, along with around the clock cortisol control. To start off this stack we have the most versatile non stimulant fat burner on the market:

    Adipose Annihilation v2 Under the Spotlight

    In this stack we have Adipose Annihilation V2, which is a non stimulant fat burner to enhance the way your body uses and gets fid of fuel. Synergy is the key to these remarkable results; AAv2’s ingredients complement one another to create “2 + 2 = 5” fat melting maximization. Hydroxycitric Acid and Acetyl-L-Carnitine in the FAT MOBILIZATION COMPLEX interact to mobilize and transport fat. Then the EBF ANNIHILATION COMPLEX takes over, as Fucoxanthin, Alpha Yohimbine, and Capsaicin combine to vanquish fat stores through PPARγ receptor antagonism. The Evodiamine, and Ginkgo Biloba Extract in AAv2 take body recomposition to a new level, boosting thermogenesis, regulating thyroid activity, and producing preferential glucose uptake.

    Garcinia Cambogia 50% HCA (Hydroxycitric Acid) is a potent plant derivative with clinically proven lipid metabolism/oxidation potential [3]. Via inhibition of Malonyl Coenzyme A, the so called “building blocks” of fat, it blocks adipose production for upwards of twelve hours after a meal [4, 5]. As HCA stops creation of new fat cells, it simultaneously prompts adipose and liver tissue to oxidize bodily fat stores. By slowing gastric emptying, HCA lowers post-prandial glucose response [6]. Clinical supplementation with Garcinia Cambogia led to, “significantly reduced visceral, subcutaneous, and total fat areas compared with the placebo group,” and, moreover, no visceral fat regain after cessation of use [7]. Beyond this, in a hypocaloric environment – created when one begins to diet – HCA will also help limit muscular catabolism and breakdown [4]. Not only does HCA help prevent fat gain, HCA increases fatty acid oxidation and expression of GLUT-4 protein and glycogen supercompensation during physical activity [7,8].

    HCA shown data that has displayed supercompensation of glycogen during physical exercise with increase fatty acid oxidation, but as well as showing increased expression of CD36 in the presence of a high carbohydrate meal showing that there is an increase in fatty acid oxidation while continuing to eat carbohydrates [14]. This fits in perfect for those who want to remain in the elusive fat burning zone after a high glycemic post workout carbohydrate meal.

    Acetyl-L-Carnitine ALCAR assumes an essential duty in the FAT MOBILIZATION COMPLEX, activating and transporting fat cells for beta oxidation [8]. Its ability to support bodily energy metabolism and insulin response creates innumerable health benefits. One clinical study found that, “safely ameliorated arterial hypertension, insulin resistance, impaired glucose tolerance, and hypoadiponectinemia in subjects” [9]. ALCAR supplementation may help overcome leptin resistance; a hormonal shift often responsible for the metabolic slowdown and fat loss plateaus that dieters experience [10]. Marked increase in dopamine levels and prevention of stress-related hormonal depletion are additional benefits that ALCAR can provide to those in a caloric deficit, to make their diet quicker, easier, and more effective [11, 12].

    Choline Bitratrate is a B Vitamin that prevents fat deposition in the liver, encourages liver fatty acid metabolism and increases subsequent oxidation [13, 14]. When paired with carnitine in medical trials, the two supplements fashioned synergistic improvements in fat mobilization. Fat is literally flushed out of the body, in the form of urinary acylcarnitines [15].

    Fucoxanthin can restrict differentiation of preadipocytes to adipocytes by means of PPARγ down-regulation. Thus, this algae extract limits the opportunity that adipose cells have to form and accumulate in the body [16]. A cutting-edge supplement in the dieter’s arsenal, Fucoxanthin is rapidly garnering popularity as an uncoupler. Recent Hokkaido University trials found that Fucoxanthin augmented expression of mitochondrial uncoupling protein 1 (UCP1). In turn, UCP1 expression shrank abdominal white adipose tissue cells; resultant net body composition changes in Fucoxanthin-fed subjects were undeniably positive [17].

    Alpha Yohimbine is a forceful α2 adrenergic antagonist; compared to standard Yohimbine, Alpha Yohimbine’s impact on α2B and α2C adrenoreceptors is three and four times more potent, respectively [18, 20]. As such, it capably enhances vasodilation/blood flow in adipose cells [19]. Because Alpha Yohimbine modulates α2C prevalent in the brain, epinephrine – along with concurrent nutrient utilization, thermogenesis, and energy metabolism – is maximally activated, whilst breakdown of serotonin, noradrenaline, and dopamine are controlled [20].

    Capsicium Annum 8% Capsaicinoids increases energy expenditure and metabolic rate through multiple pathways [21, 22]. Studies claim, “capsaicin also inhibited the expression of PPARγ, C/EBPα, and leptin, but induced up-regulation of adiponectin at the protein level. These results demonstrate that capsaicin efficiently induces apoptosis and inhibits adipogenesis in 3T3-L1 preadipocytes and adipocytes” [23]. PPARγ modulation causes the bulk of adipose loss to be exhibited on ugly abdominal fat stores [24]. Capsaicinoid dosage in V2.0’s EBF ANNIHILATION COMPLEX has been reduced to .5mg per pill, resulting in similar increased post-ingestion glycerol and blood FFA levels seen in V1.0, without the potential for heartburn-like side-effects [25].

    Evodiamine is an essential new addition to the re-formulated AAv2. This ingredient “mimics the characteristic anti-obese effects induced by capsaicin” to “induce heat loss and heat production at the same time and dissipate food energy, preventing the accumulation of perivisceral fat and the body weight increase” [26]. Inclusion of Evodiamine has reduced the required amount of Capsaicinoids in V2.0’s proprietary blend – this reduction, in turn will maintain all the effectiveness of the original formulation, without the potential for occurrence of heartburn at higher Capsaicinoid dosages. A recent medical study found that Evodiamine’s ability to inhibit adipocyte differentiation and limit fat gain – unlike Capsaicin - is not reliant on a mechanism of action involving uncoupling protein-1 (UCP1) thermogenesis [27]. Therefore, utilization of these two ingredients together can produce similar and cumulative effects by channeling multiple bodily pathways.

    Ginko Biloba Extract is a compound that contains naturally-occurring flavonoids such as Kaempferol and Quercetin. Kaempferol is known to promote overall body/mind wellness through antioxidant, anti-inflammatory, cardioprotective, and neuroprotective activities [28]. Significant improvements in insulin-stimulated glucose uptake can be provided via Kaempferol supplementation, due to an ability to “act at multiple targets to ameliorate hyperglycemia, including by acting as partial agonists of PPARγ”; this partial PPARγ modulation “activates some (insulin sensitization), but not all (adipogenesis), PPARγ-signaling pathways” [29, 31]. Furthermore, in a separate FDA-sponsored study, both Kaempferol and Quercetin were proven to “down-regulate the adipogenesis-related transcriptional factors PPARγ, C/EBP-α and SREBP-1 and to inhibit adipocyte differentiation during the early stage” [30]. Couple this mechanism of action with Kaempferol’s known capacity to regulate D2-mediated thyroid activity (T3 production), and the result is truly astounding cumulative 2+2=5 fat-burning potential [32].

    Now let’s take a look at the other side of the coin…the strongest stimmed fat burner on the market.

  2. Alphamine Under the Spotlight

    Consumers got their first “taste” of Alphamine in 2012 and it didn’t take long for Alphamine to become one of the top sellers in the category due to the overwhelmingly positive feedback it received. Alphamine was unique because it was the first effective powdered fat burner on the market. What was once impossible to give consumers due to the need to take 10-20 capsules/day now became a reality as 2-3 scoops of Alphamine could provide full doses of effective fat-burning ingredients beyond the scope of what other companies could supply in capsule or pill form.
    The benefit of having a thermogenic in a powder format is that users can customize their own dosage more precisely than is possible with an encapsulated product. The limit with caffeine based products is that you can either take one capsule or two. With Alphamine you can split the serving sizes to exactly what you are looking for based on your own personal stimulant tolerance. In the early stages of the Alphamine release, the importance of this was obvious, as some consumers used only half a scoop (one quarter of the maximum dosage), while those with a higher stimulant tolerance would use two full scoops.
    The idea behind Alphamine is to have a thermogenic product with higher doses of active ingredients whilst being in a format that allows flexible dosing, as well as being pleasant to drink.
    Additionally, Alphamine was the first fat burner to focus not just on fat loss but preserving muscle tissue as well, as it contained ingredients that not only spared muscle in a caloric deficit but could actually increase muscle mass while cutting. In this respect, Alphamine was termed a dual-leaning-hardening agent, and the scientific data on the various compounds appears to support these claims.
    Let’s take a brief look at each ingredient and how each one is geared towards Alphamine’s goal of simultaneously maximizing fat loss and muscle gain:
    · Choline Bitartrate – Choline has a variety of roles in the human body, but the specific purpose of Choline in Alphamine is elevation of growth hormone, lipolysis, and mood boost, all of which is achieved through its ability to gain an acetyl group from the enzyme Choline Acetyltransferase in order to form the neurotransmitter: acetylcholine.

    o Choline Bitartrate Summary: Increased Growth Hormone, Lipolysis, and Mood Elevation

    · Alpha-Hydroxy-Isocaproic Acid (HICA) – HICA has been investigated in athletes in two separate trials. It was found that 500mg 3x/day more than doubled the rate of LBM (muscle) gain relative to placebo. It also did not cause any increase in fat mass, whereas the placebo group gained a significant amount of fat. Thus, HICA appears to be a body recomposition tool for increasing muscle mass and limiting fat gain. As an added bonus, the study also found that HICA reduces soreness following exercise1.

    o HICA Summary: Increased muscle mass, reduced fat mass, and reduced soreness

    · Eucommia Ulmoides Leaf (98% Chlorogenic Acid) – Chlorogenic acid has recently gained public fame due to Green Coffee Bean extract, which reduces fat mass via its main active chlorogenic acid. A good Green Coffee Bean Extract contains 50% chlorogenic acid, while this Eucommia Ulmoides extract contains 98% chlorogenic acid. Chlorogenic acid works by positively modulating carbohydrate metabolism, and numerous human trials have shown reductions in fat mass with continuous supplementation. In fact, one trial showed over 3x the fat loss in the chlorogenic acid group relative to placebo2.

    o Chlorogenic Acid Summary: Reduced fat mass and improved glycemic control

    · Olea Europaea Leaf (Extracted for Oleuropein) – Olea Europaea, or Olive Leaf, contains the active compound Oleuropin, which has been shown to stimulate 3’/5’-deiodinase, the enzyme responsible for converting T4 to T33. What this means is simple: you have more active thyroid hormone in your body, leading to increase metabolic rate and fat loss. In addition, Oleuropein is a well-characterized uncoupling agent4, meaning that it increases adrenaline release and thermogenesis, further boosting metabolic rate. Both of these benefits have been demonstrated in murine trials, in which Oleuropein managed to reduce all the negative effects associated with an unhealthy diet5.

    o Oleuropein Summary: Thyroid boost, increased metabolic rate, and reduced fat mass

    · Caffeine Anhydrous – Caffeine really needs no introduction here. It is extremely well-researched and has been shown to improve mood, alertness, energy, and yes, fat loss.

    o Caffeine Summary – Improved fat loss and energy levels

    · Higenamine HCl – Higenamine is a selective beta-adrenergic receptor agonist6. This is the same receptor exploited by drugs like ephedrine and clenbuterol in order to dually stimulate fat loss and spare muscle mass. Therefore, Higenamine will synergize with caffeine, as caffeine potentiates the cAMP transduction cascade, which is a set of reactions that is downstream from the stimulation of the beta-adrenergic receptor.

    o Higenamine Summary: Reduced fat mass, preserved muscle mass, and synergy with caffeine

    · Tembamide – Tembamide is a novel beta-3-adrenergic receptor agonist that has been shown to improve metabolism and dyslipidemia7. The beta-3-adrenergic receptor is localized to adipose tissue and serves one role: thermogenesis and fat loss. Like Higenamine, Tembamide will also synergize with caffeine, which serves to amplify the lipolytic signal.

    o Tembamide Summary: Reduced fat mass, increased thermogenesis, and synergy with caffeine

    · N-Coumaroyldopamine – N-Coumaroyldopamine is a highly selective beta-2-adrenergic receptor agonist8, comparable in potency to the well-known fat loss and asthma drug: Clenbuterol. Unlike Clenbuterol, the selectively of N-Coumaroyldopamine means that it doesn’t activate beta-1-adrenergic receptors. This translates into zero unhealthy effects and more of the fat loss that consumers are after. As a beta-adrenergic-receptor agonist, it too will synergize with caffeine like the aforementioned beta-agonists.

    o N-Coumaroyldopamine Summary: High potency fat loss, muscle preservation, and synergy with caffeine

    To summarize the above, Alphamine:
    · Maximizes beta-adrenergic-receptor-mediated fat loss and muscle preservation
    o Via synergy between Higenamine HCl, N-Coumaroyldopamine, Tembamide, and Caffeine
    · Increases muscle mass and inhibits fat gain
    o Via Alpha-Hydroxy-Isocaproic Acid (HICA)
    · Increases metabolic rate and naturally improves thyroid function
    o Via Olea Europaea Leaf (Extracted for Oleuropein)
    · Improves glucose metabolism and glycemic control
    o Via Eucommia Ulmoides Leaf (98% Chlorogenic Acid)
    · Increases growth hormone release
    o Via Choline Bitartrate

    Taking the wide array of effects into consideration, Alphamine would be best for those who not only seek to lose weight but also want to make sure that the weight lost is coming from fat stores and not muscle mass.

    The synergy of AAv2s ingredients continues when stacked with Alphamine…

    Alphamine is chiefly lipolytic in nature, accelerating the breakdown of triglycerides to free fatty acids. This is paired with AAv2, which chiefly targets beta-oxidation and fat storage. So you cover all 3 corners of the triangle: lipolysis, fat oxidation, and reduction of fat storage.
    The Fucoxanthin found in AAv2 is a thermogenic uncoupler, increasing metabolism and calories burnt…this works exceptionally well with Oleuropein found in Alphamine, a thyrogenic ingredient that further raises metabolism.
    Ingredients like Chlorogenic acid found in Eucommia Ulmoides has been shown to stimulant lipolysis and thermogenesis while simultaneously suppressing appetite in the animal model. Other ingredients like caffeine add fuel to fat burning fire that AAv2 creates, as caffeine synergizes with rauwolscine and the SA2A and b-agonists found in both products.

    One ingredient in particular, the N-Coumaroyldopamine in Alphamine, is one of the most selective beta-2 agonist compounds in nature. It has a unique ability to be so selective that cardiac stimulation is greatly avoided, making it very useful towards beta-agonists other promising properties. Anecdotally, beta-agonists with selectivity like NCD shine in the muscle sparing and muscle hardening aspects. If we had to choose a phrase to describe this ingredient…we would use Flex Appeal.

    NCD has been the rave for getting dense firm muscle tissue, and we suspect ultra-selective beta-2 agonists such as NCD may be the future of leaning and hardening agents in the industry. We deliver it here in its purest form.

    Add the above to HICA (leucic acid) you have a fat burning muscle sparing stack that will literally melt fat off of your body.

    Lastly, let’s look at how ingredients like capsicum and evodiamine will contribute to thermogenesis. We’ll keep it short and simple…you will be HOT!!!! Adrenergic signaling from alphamine + increased metabolic rate from bother products + 100% thermogenic compounds like capsicum and evodiamine will take your fat loss to the next level indeed. Add to that a little known effect of ginkgo biloba (improved bloodflow), and you have increased delivery of these potent compounds all over the body: to fat to liberate fat stores, to the liver to burn them off, and to the brain to keep you feeling your best in a caloric deficit.

    No one’s diet is perfect, but Alphamine and AAv2, body composition should shift towards a favorable endpoint: more muscle and less fat.
    But lowering fat storage and lipogenesis are only one side of the coin.
    There really is no parallel to what we’re working with here. The synergy is on another level when it comes to body recomposition, so get in here ASAP because when it comes to well-dosed, science based formulas, you’re dealing with two of the best in EBF and PES.
    This is the first time the ultimate fat loss stack has been offered as a combo for a promotion, and with the results we’re expecting, it likely won’t be the last!

  3. AAv2 References

    [1] Pedersen, S. B., Kristensen, K., Hermann, P. A., Katzenellenbogen, J. A., Richelsen, B. (2004). Estrogen Controls Lipolysis by Up-Regulating {alpha}2A-Adrenergic Receptors Directly in Human Adipose Tissue through the Estrogen Receptor {alpha}. Implications for the Female Fat Distribution. J. Clin. Endocrinol. Metab. 89: 1869-1878
    [2] Lee, Y. (2006). Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and Insulin-Resistant States Diabetes, 55 (8), 2256-2264
    [3] Shara M, Ohia SE, Yasmin T, et al. (2003). "Dose- and time-dependent effects of a novel (-)-hydroxycitric acid extract on body weight, hepatic and testicular lipid peroxidation, DNA fragmentation and histopathological data over a period of 90 days". Mol. Cell. Biochem. 254 (1-2): 339.46.
    [4] Sherwin RS et al.; Journal of Clinical Invest.;1975 55:1382-1390
    [5] Triscari J, Sullivan AC. Comparative effects of (-)-hydroxycitrate and (+)-allo-hydroxycitrate on acetyl CoA carboxylase and fatty acid and cholesterol synthesis in vivo. Lipids 1977;12:357.63.
    [6] Am J Physiol Gastrointest Liver Physiol. 2005 Jun;288(6):G1144-9.
    [7] Effects of garcinia cambogia (Hydroxycitric Acid) on visceral fat accumulation: a double-blind, randomized, placebo-controlled trial.; Kohsuke Hayamizu MS et al.; Current Therapeutic Research.; Volume 64, Issue 8, September-October 2003, Pages 551-567
    [8] Flanagan et al., Role of carnitine in disease Nutrition & Metabolism 2010, 7:30
    [9] Ruggenenti P, Cattaneo D, Loriga G, Ledda F, Motterlini N, Gherardi G, Orisio S, Remuzzi G. Ameliorating hypertension and insulin resistance in subjects at increased cardiovascular risk: effects of acetyl-L-carnitine therapy. Hypertension. 2009; 54: 567.574.
    [10] Iossa S, Mollica MP, Lionetti L, Crescenzo R, Botta M, Barletta A, Liverini G. Acetyl-L-carnitine supplementation differently influences nutrient partitioning, serum leptin concentration and skeletal muscle mitochondrial respiration in young and old rats. J Nutr 2002 Apr;132(4):636-42
    [11] Bidzinska B, Petraglia F, Angioni S, Genazzani AD, Criscuolo M, Ficarra G, Gallinelli A, Trentini GP, Genazzani AR. Effect of different chronic intermittent stressors and acetyl-l-carnitine on hypothalamic beta-endorphin and GnRH and on plasma testosterone levels in male rats. Neuroendocrinology 1993 Jun;57(6):985-90
    [12] Toth E, Harsing LG Jr, Sershen H, Ramacci MT, Lajtha A. Effect of acetyl-L-carnitine on extracellular amino acid levels in vivo in rat brain regions. Neurochem Res 1993 May;18(5):573-8
    [13] Best, C. H., and M. E. Huntsman 1934 The effect of choline on the liver fat of rats in various states of nutrition. J. Physiol., 83: 255.
    [14] Artom, C. (1953) Role of choline in the oxidation of fatty acids by the liver. J. Biol. Chem. 205: 101-111.
    [15] Hongu N, Sachan DS. Carnitine and choline supplementation with exercise alter carnitine profiles, biochemical markers of fat metabolism and serum leptin concentration in healthy women. J Nutr. 2003; 133(1):84-9.
    [16] Maeda H, Hosokawa M, Sashima T, et al. (2006) Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells. Int J Mol Med 18, 147.152.
    [17] Maeda, H; Hosokawa, M; Sashima, T; Funayama, K; Miya****a, K (2005). "Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues". Biochemical and biophysical research communications 332 (2): 392.7.
    [18] Timmermans PB, Qian JQ, Ruffolo RR, Jr, van Zwieten PA. A study of the selectivity and potency of rauwolscine, RX 781094 and RS 21361 as antagonists of alpha-1 and alpha-2 adrenoceptors. J Pharmacol Exp Ther. 1984 Mar;228(3):739.748.
    [19] Galitzky J, Lafontan M, Nordenstrom J, Arner P. Role of vascular alpha-2 adrenoceptors in regulating lipid mobilization from human adipose tissue. J Clin Invest 1993; 91:1997-2003.
    [20] Convents A, Convents D, De Backer JP, De Keyser J, Vauquelin G. High affinity binding of 3H rauwolscine and 3H RX781094 to alpha 2 adrenergic receptors and non-stereoselective sites in human and rabbit brain cortex membranes. Biochem Pharmacol. 1989 Feb 1;38(3):455.463.
    [21] Non-pungent capsaicin analogs (capsinoids) increase metabolic rate and enhance thermogenesis via gastrointestinal TRPV1 in mice. Kawabata F, Inoue N, Masamoto Y, Matsumura S, Kimura W, Kadowaki M, Higashi T, Tominaga M, Inoue K, Fushiki T. Biosci Biotechnol Biochem. 2009 Dec;73(12):2690-7. Epub 2009 Dec 7.
    [22] Han J. et al., Capsaicin induced the upregulation of transcriptional and translational expression of glycolytic enzymes related to energy metabolism in human intestinal epithelial cells. J. Agric. Food Chem. 2009 Dec 9, 57(23). 11148-53.
    [23] Journal of Agricultural and Food Chemistry: Volume 55, Pages 1730-1736: "Effects of Capsaicin on Induction of Apoptosis and Inhibition of Adipogenesis in 3T3-L1 Cells" Authors: C.-L. Hsu and G.-C. Yen
    [24] Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications.Am J Clin Nutr. 2009 Jan;89(1):45-50. Epub 2008 Dec 3.
    [25] Bloomer, Richard, Robert Canale, Sid Shastri, and Sujata Suvarnapathki. "Effect of oral intake of capsaicinoid beadlets on catecholamine secretion and blood markers of lipolysis in healthy adults: a randomized, placebo controlled, double-blind, cross-over study." Lipids in Health and Disease 9 (July 2010): 72+.
    [26] Kobayashi Y, Nakano Y, Kizaki M, Hoshikuma K, Yokoo Y, Kamiya T. Capsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist. Planta Med. 2001;67(7):628.633. doi: 10.1055/s-2001-17353.
    [27] Wang T, Wang Y, Kontani Y, Kobayashi Y, Sato Y, Mori N, & Yama****a H. (2008). Evodiamine improves diet-induced obesity in a uncoupling protein-1-independent manner: involvement of antiadipogenic mechanism and extracellularly regulated kinase/mitogen-activated protein kinase signaling. Endocrinology. 149(1), 358-66.
    [28] Calderon-Montano JM, Burgos-Moron E, Perez-Guerrero C, Lopez-Lazaro M. (2011). "A review on the dietary flavonoid kaempferol.". Mini Rev Med Chem. 11 (4): 298.344.
    [29] Fang XK, Gao J, Zhu DN. Kaempferol and quercetin isolated from Euonymus alatus improve glucose uptake of 3T3-L1 cells without adipogenesis activity. Life Sci. 2008 Mar 12;82(11-12):615-22.
    [30] Chien Po-Jung et al., Dietary Flavonoids Suppress Adipogenesis in 3T3-L1 Preadipocytes. Journal of Food and Drug Analysis, Vol. 13, No. 2, 2005, Pages 168-175
    [31] Misra P, Chakrabarti R, Vikramadithyan RK, et al. PAT5A: a partial agonist of peroxisome proliferator-activated receptor ƒÁ is a potent antidiabetic thiazolidinedione yet weakly adipogenic. Journal of Pharmacology and Experimental Therapeutics. 2003;306(2):763.771.
    [32] da-Silva WS, Harney JW, Kim BW, Li J, Bianco SD, Crescenzi A, Christoffolete MA, Huang SA, Bianco AC. The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation. Diabetes. 2007 Mar;56(3):767-76.
    [33] Hatzivassiliou G, Zhao F, Bauer DE, et al. ATP citrate lyase inhibition can suppress tumor cell growth. Cancer Cell 2005; 8: 311.21.
    [34] Sinicropi MS, Amantea D, Caruso A, Saturnino C. Chemical and biological properties of toxic metals and use of chelating agents for the pharmacological treatment of metal poisoning. Arch Toxicol. 2010 Jul;84(7):501-20. Epub 2010 Apr 13.
    [35] Glusker, J. P. 1980. Citrate conformation and chelation: enzymic implications. Acc. Chem. Res. 13:345-352.
    [36] CJ Rebouche. Carnitine function and requirements during the life cycle. FASEB J. 6: 3379-3386.
    [37] Siliprandi, N., Di Lisa, F. and Menabo, R.: Propionyl-L-carnitine: Biochemical significance and possible role in cardiac metabolism. Cardiovasc. Drugs Ther. 5: suppl. 1, 11.15, 1991.
    [38] Choline and Human Nutrition. S H Zeisel, J K Blusztajn. Annual Review of Nutrition 1994 14, 269-. 296.
    [39] Babb SM, Ke Y, Lange N, Kaufman MJ, Renshaw PF, Cohen BM (2004) Oral choline increases choline metabolites in human brain. Psychiatry Res 130:1.9.
    [40] Hosokawa M, Kudo M, Maeda H, Kohno H, Tanaka T and Miya****a K: Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPARgamma ligand, troglitazone, on colon cancer cells. Biochim Biophys Acta 1675: 113-119, 2004.
    [41] R. W. P. Achor, N. O. Hanson, and R. W. Gifford Jr. Hypertension treated with Rauwolfia Serpentina (whole root) and with reserpine: controlled study disclosing occasional severe depression JAMA, October 29, 1955; 159(9): 841 . 845.
    [42] WILKINS RW, JUDSON WE. The use of Rauwolfia serpentina in hypertensive patients. N Engl J Med. 1953 Jan 8;248(2):48-53.
    [43] Effects of Capsaicin, Dihydrocapsaicin, and Curcumin on Copper-Induced Oxidation of Human Serum Lipids. Kiran D. K. Ahuja,, Dale A. Kunde,, Madeleine J. Ball, and, Dominic P. Geraghty Journal of Agricultural and Food Chemistry 2006 54 (17), 6436-6439.
    [44] Jennifer Rieusset, Fethi Touri, Liliane Michalik, Pascal Escher, Beatrice Desvergne, Eric Niesor, and Walter Wahli. A NEW SELECTIVE PPAR ANTAGONIST WITH ANTI-OBESITY AND ANTI-DIABETIC ACTIVITY. Mol. Endocrinol. published August 8, 2002, doi:10.1210/me.2002-0036
    [45] Ginkgo biloba extract kaempferol inhibits cell proliferation and induces apoptosis in pancreatic cancer cells. J Surg Res. 2008 Jul;148(1):17-23. Epub 2008 Mar 26

    [2] Shara M, Ohia SE, Yasmin T, Zardetto-Smith A, Kincaid A, Bagchi M, Chatterjee A, Bagchi D, Stohs SJ, (2003), Dose- and time-dependent effects of a novel (-)-hydroxycitric acid extract on body weight, hepatic and testicular lipid peroxidation, DNA fragmentation and histopathological data over a period of 90 days. Mol Cell Biochem. Dec;254(1-2):339-46.
    [3] Sherwin RS et al. ; Journal of Clinical Invest.; 1975 55:1382-1390
    [4] Triscari J, Sullivan AC, (1977), Comparative effects of (--)-hydroxycitrate and (+)-allo-hydroxycitrate on acetyl CoA carboxylase and fatty acid and cholesterol synthesis in vivo, Lipids. Apr;12(4):357-63.
    [5] AM J Physiol Gastrointest Liver Physiol. 2005 Jun;288(6):G1144-9
    [6] Effects of Garcinia cambogia (Hydroxycitric Acid) on Visceral Fat Accumulation: A Double-Blind, Randomized, Placebo-Controlled Trial, Kohsuke Hayamizu et al. ; Current Therapeutic Research. ; Volume 64, Issue 8, September – October 2003, Pages 551 - 567

    [7] Effects of acute (−)-hydroxycitrate supplementation on substrate metabolism at rest and during exercise in humans, Luc JC van Loon et al.; The American Journal of Clinical Nutrition ;2000.
    [8] Cheng IS et al. Oral hydroxycitrate supplementation enhances glycogen synthesis in exercised human skeletal muscle. Br J Nutr. 2012 Apr;107(7):1048-55. doi: 10.1017/S0007114511003862. Epub 2011 Aug 9

    Alphamine References
    1. Mero, Antti A., Tuomo Ojala, Juha J. Hulmi, Risto Puurtinen, Tuomo AM Karila, and Timo Seppälä. "Effects of Alfa-hydroxy-isocaproic Acid on Body Composition, DOMS and Performance in Athletes." Journal of the International Society of Sports Nutrition 7.1 (2010): 1. Print.
    2. Thom, E. "The Effect of Chlorogenic Acid Enriched Coffee on Glucose Absorption in Healthy Volunteers and Its Effect on Body Mass When Used Long-term in Overweight and Obese People." J Int Med Res 35.6 (2007): 900-08. Web.
    3. Al-Qarawi, A. A., M. A. Al-Damegh, and S. A. ElMougy. "Effect of Freeze Dried Extract of Olea Europaea on the Pituitary-thyroid Axis in Rats." Phytotherapy Research 16.3 (2002): 286-87. Web.
    4. Oi-KANO, Yuriko, Teruo Kawada, Tatsuo Watanabe, Fumihiro Koyama, Kenichi Watanabe, Reijirou Senbongi, and Kazuo Iwai. "Oleuropein, a Phenolic Compound in Extra Virgin Olive Oil, Increases Uncoupling Protein 1 Content in Brown Adipose Tissue and Enhances Noradrenaline and Adrenaline Secretions in Rats." Journal of Nutritional Science and Vitaminology 54.5 (2008): 363-70. Web.
    5. Poudyal, H., F. Campbell, and L. Brown. "Olive Leaf Extract Attenuates Cardiac, Hepatic, and Metabolic Changes in High Carbohydrate-, High Fat-Fed Rats."Journal of Nutrition 140.5 (2010): 946-53. Web.
    6. Bai, G., Y. Yang, Q. Shi, Z. Liu, Q. Zhang, and YY Zhu. Acta Pharmacol Sin 29.10 (2008): 1187-194. Print.
    7. Narender, T., K. Rajendar, S. Sarkar, V.k. Singh, Upma Chaturvedi, A.k. Khanna, and G. Bhatia. "Synthesis of Novel N-(2-hydroxy-2-p-tolylethyl)-amide and N-(2-oxo-2-p-tolylethyl)-amide Derivatives and Their Antidyslipidemic and Antioxidant Activity." Bioorganic & Medicinal Chemistry Letters 21.21 (2011): 6393-397. Print.
    8. Park, Jae B. "N-Coumaroyldopamine and N-caffeoyldopamine Increase CAMP via Beta 2-adrenoceptors in Myelocytic U937 Cells." The FASEB Journal 19.6 (2005): 497-502. Web.

  4. Huge opportunity here.

  5. This is a great promo guys lets get on some applications

  6. Longest intro to a promo, ever.

    Should be a good ride!
    Carry on.

  7. Quote Originally Posted by EBF Inc View Post
    This is a great promo guys lets get on some applications
    In order to apply:

    Be 18+
    US resident

    Why you want to run the stack

    Expectations of the stack

    Best FML story that's ever happened to you or a picture of you at your leanest to see if we can get you leaner

  8. i would love to try this but don't know the rules for iforce reps well enough to apply very cool tho coop! get dem boys all ripped up in hurr!
    Vicious Labs
    Want 10% Off? Use Code RIPP10

  9. Whoa, nice opp here!

  10. Sick stack!
    PEScience Representative
    Instagram: kylebayne23

  11. Woah AAV2 has a lot of references surrounding it lol
    Serious Nutrition Solutions Representative
    X-gels for strength, Focus XT for mental performance & Joint Support XT for pain free mobility

  12. What's the timeframe for this look like (when will you be picking loggers, expected to start)? I'd love to log this but ill be starting a glycophase log next week and prob shouldn't overlap them.
    Serious Nutrition Solutions Product Rep - db77 @ seriousnutritionsolutions.com

  13. Quote Originally Posted by Jiigzz View Post
    Woah AAV2 has a lot of references surrounding it lol
    Very thorough

  14. Man I would love to run this. It says picture of you at your leanest, to see if we can get you leaner lol. I was 175 in 2006, I am 298 currently. Although I love Alphamine, and have always wanted to try AAV2, don't think I can lose 125lbs in a month. That would be record breaking haha
    Performax Labs Product Specialist
    Like Us On Facebook:
    Visit our site at www.performaxlabs.com

  15. Quote Originally Posted by cubsfan815 View Post
    Man I would love to run this. It says picture of you at your leanest, to see if we can get you leaner lol. I was 175 in 2006, I am 298 currently. Although I love Alphamine, and have always wanted to try AAV2, don't think I can lose 125lbs in a month. That would be record breaking haha
    Lol or post your best fml story..
  16. AnabolicMinds Site Rep
    The Solution's Avatar

    Why did you not tell me about this!?

    Guys get in on this!
    Anabolic Minds Site Rep

  17. Quote Originally Posted by EBF Inc View Post
    Lol or post your best fml story..
    Going from 175 to 325 Lmao!
    Performax Labs Product Specialist
    Like Us On Facebook:
    Visit our site at www.performaxlabs.com

  18. Damn, not planning on a cut until at least 40 days or so out. Ha ha ha.

  19. Quote Originally Posted by cubsfan815 View Post
    Going from 175 to 325 Lmao!
    PEScience Representative

  20. May I drop in an app Cybear? I'm in dire need for some cutting and not mention a log for accountability and consistency ! Not to mention I am always willing to post pics, detailed nutrition and consistent feedback with 100% honest reviews in the end.
    Serious Nutrition Solutions Rep

  21. Quote Originally Posted by EBF Inc View Post
    In order to apply:

    Be 18+
    US resident

    Why you want to run the stack

    Expectations of the stack

    Best FML story that's ever happened to you or a picture of you at your leanest to see if we can get you leaner
    This is the EBF criteria.

    For the PES criteria.

    - Worldwide applicants
    - Must be happy to send bribes to me
    - If struggling for money I will take nude photos on the condition I can sell them onto dodgy websites.

    PEScience Representative

  22. Quote Originally Posted by bdcc View Post

    This is the EBF criteria.

    For the PES criteria.

    - Worldwide applicants
    - Must be happy to send bribes to me
    - If struggling for money I will take nude photos on the condition I can sell them onto dodgy websites.

    Sounds about right

  23. Quote Originally Posted by bdcc View Post
    This is the EBF criteria.

    For the PES criteria.

    - Worldwide applicants
    - Must be happy to send bribes to me
    - If struggling for money I will take nude photos on the condition I can sell them onto dodgy websites.

    I has to ask permission first ! but lets see:

    Be 18+: 22
    US resident: Citizen

    Why you want to run the stack: Had surgery and seriously need to keep dropping my body fat down from the mess it was. After recovery I was a bloated 152lbs with rolls and rolls of fat. Have dropped down now to 144 in the past weeks with consistent cardio and a hypocaloric diet allowing myself just 1 cheat meal every 2 weeks to preserve sanity and motivation...and it has been in the form of Chicken Wings at Buffalo wild wings (which will come up in the story actually in a sec!).

    My goal is always lean up and then start up a lean bulk cycle, which I had done before and had worked my way up to a good weight with good lifts, but the surgery left a toll on me along with some personal issues, stress and some medical conditions (all has been solved now thank God) and lost a lot of LBM and put on a pillsbury doughboy shape. So time to Lean up again and keep moving forward.

    Expectations of the stack: Help me get rid of some stubborn BF I have in my lower back and help me cut up my abdominal section since it is already leaning up. For 4 weeks, I expect to see (according to the diet I've been restricting along with cardio) 4-6 less lbs and with Alphamine and AAv2 I hope that it will be mostly fat mass, alas some deflation of my fat cells.

    Best FML story that's ever happened to you or a picture of you at your leanest to see if we can get you leaner:

    Lets see...not of my life, but of this new chapter of my life and it actually happened on sunday haha.

    So I go in to the Cheat Meal for Buffalo Wild Wings with 2 bro's of mine, at around 9pm...the waitress sits us down and we get a really nice waitress who asks us were we are from, for I have a tendency to shift accents a lot. Though I never portray a Latin, Mexican or Spanish accent. At the moment it was of your typical southern Texan but hell...what do I know? My 2 other friends had a strong accent however, one Latin and one Middle eastern (he is from Pakistan) so she asks were are we from? We go ahead and tell her and we chit chat about the parents and all that...she didn't believe my dad was from Span and my mamma from Mexico, so I had to prove a point and I ordered some Atomic wings! (Love it nice and hot haha)...well as a silly macho thing to do I came to regret it later. She brings them along with a second round of drinks (for me it was just water). I knew it was gonna be an awkward night when I had the stupidity of dropping a Water Joke when she took the order ¬¬' I said: "Well for me...a glass of your freshest...most delicious...and coldest water!! And don't skimp on the ice please !" Yeah...I did that...but my other 2 bro's had beers and what could I do? Make a fool of myself...she gave me the look of: "Really?".

    So anyhow she brings the wings and another glass of water for me...right as she does another friend arrives, so get up to greet him and knock the glass of water over and she gets splashed...right then i notice she had a little baby belly! I thought to myself.."You can't be an ass and make her wipe your mess!" so I took some napkins immediately and cleaned the table as she gave me the stink eye ! And followed up to pick up the ice from the rug as she left to bring me another water and get cleaned up. Dinner goes on, we laugh, we joke, we eat wings and when she comes back I'm tearing up and gulping water and she said: "Told yah it was too hot!" and I said: "Nonesense!! I got Spanish blood in me! this is nothing !" and my Latin friend says (trying to be, i don't know, funny?) "It's ok , he's not as white as you so he might be able to take it chica!"...I seriously think he exaggerated the George Lopez accent...and she DIDN'T laugh...obviously...and yeah she leaves and after us making her uncomfortable and me being a klutz and knocking over the water I decide to leaver her a big tip...so I pay with the card and leave her a 20 at the table with my signed ticket. And for the life of me idk what was going on in my head...I wrote: "Sorry for being a klutz! And congrats on your baby !"...so we stand up, go for the door...right before we get out, from the other end of the restaurant at our table comes a scream of anger and "i've had enough":


    Yeah...**** my life...that was my favorite wings spot...

    Now a pic of me at my leanest...hm let's see:
    Name:  Screen Shot 2013-07-30 at 11.36.47 AM.png
Views: 370
Size:  259.0 KBName:  Screen Shot 2013-07-30 at 11.37.15 AM.png
Views: 406
Size:  193.6 KB

    ! That a good App then?
    Serious Nutrition Solutions Rep

  24. Lol...I have at least 3 buddies who have made the mistake of asking "when are you due?" to fat chicks.

    Big tummy + regular arms and ankles: pregnant

    Big tummy + sleevebusters + cankles: fat

    Trivia: fat or pregnant?
    FeFiFo.com support
    DIESEL TEST = Underground Kings of Test elevation!

  25. Bro it was only her lower tummy! She was skinny from the arms, legs, neck...everything! I was such an idiot...but not on purpose !!
    Serious Nutrition Solutions Rep


Similar Forum Threads

  1. what are you guys stacking PRIME WITH ?!?
    By THEGEEZ in forum Supplements
    Replies: 46
    Last Post: 01-07-2009, 04:28 AM
  2. Whats do you guys think of this stack?
    By NYCmuscle in forum Supplements
    Replies: 2
    Last Post: 04-27-2008, 09:08 PM
  3. Could you guys have a look at this stack?
    By n4rcissistic in forum Supplements
    Replies: 4
    Last Post: 04-21-2008, 12:22 AM
  4. What do you guys think about this stack?
    By blahblah192 in forum Supplements
    Replies: 6
    Last Post: 09-11-2006, 04:47 PM
  5. Replies: 8
    Last Post: 05-28-2004, 02:51 AM
Log in
Log in