As many of you have already heard, these gains are completely attainable by taking The One™; the completely new pro-anabolic compound exclusively by Applied Nutriceuticals®.
The following information will provide complete how-to instructions on diet, training, and supplementation based on the most recent research available combined with new data collected from people who have taken the product. By following these instructions, you can avoid making costly mistakes will gain a better understanding of how to use The One correctly as to maximize your results.
For additional detailed discussion on the science behind The One, you can log on to www.appnut.com/product-theone.php and click on “Technical Information” and “FAQs”.
You can also listen to an in-depth discussion on Superhuman Radio between Applied Nutriceuticals’ Chief Chemist Dirk Tanis and host Carl Lenore as they discuss The One and the science of hormone-based anabolics in general: Super Human Radio Network Show Number 269.
As with any endeavor, the best results are obtained when you have a good plan. Therefore, before taking The One, there are few things you should do to prepare your body for the explosive growth it is about to undergo.
1) Receptor cleansing: You should not have taken any other hormone-based anabolic/androgenic compound for at least 90 days prior to taking The One. This will allow for a greater number of the target androgen receptors (ARs) to be accessible for the active molecule in The One to exert it effects upon.
2) Training experience: The One is not for use for first-timers in the gym. We recommend that you have at least one year experience in weight training and are consistent and passionate about sticking to your regimen.
3) Contraindicated Products:Below is a non-exclusive list of prescription and non-prescription products that should not be taken in conjunction with The One and/or 2nd Gear:
a. Antibiotics: They will hinder re-absorption of The One by the intestine after first pass, as they kill the bacteria needed to change the molecule into a usable form.
b. Saw Palmetto (Serenoa repens): Competes with DHT for receptors; therefore significantly diminishes the ability for the active ingredient in The One to have any effect. Reference study: Planta Med. 2006 Jul;72(9):807-13. Epub 2006 Jun 19. Extracts from Pygeum africanum and other ethnobotanical species with antiandrogenic activity.Schleich S, Papaioannou M, Baniahmad A, Matusch R.Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marburg, Germany, Extracts from Serenoa repens and other similar botanicals are used in the treatment of benign prostatic hyperplasia (BPH) and prostate cancer (PCa). The activity of the AR is known to control growth of the prostate. Here, they examined extracts of these plants for their anti-androgenic activity using an AR responsive reporter gene assay for drug discovery.
c. Finasteride (Brand names: Proscar®, Propecia®): Reduces serum DHT activity by 70%; therefore it will virtually eliminate any results otherwise attainable from use of The One. Reference Study: J Clin Endocrinol Metab. 2007 May;92(5):1659-65. Epub 2007 Feb 13. The effect of 5alpha-reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy men.Amory JK, Wang C, Swerdloff RS, Anawalt BD, Matsumoto AM, Bremner WJ, Walker SE, Haberer LJ, Clark RV.
Department of Medicine, Veterans Affairs-Puget Sound Health Care System, University of Washington, Seattle, WA 98195, USA. CONTEXT: Dutasteride and finasteride are 5alpha-reductase inhibitors (5ARIs) that dramatically reduce serum levels of dihydrotestosterone (DHT). Because androgens are essential for fertility, we sought to determine the impact of 5ARI administration on serum testosterone (T), DHT, and spermatogenesis. DESIGN, SETTING, SUBJECTS, AND INTERVENTION: We conducted a randomized, double-blinded, placebo-controlled trial in 99 healthy men randomly assigned to receive dutasteride (D; 0.5 mg) (n = 33), finasteride (F; 5 mg) (n = 34), or placebo (n = 32) once daily for 1 yr. RESULTS: D and F significantly (P < 0.001) suppressed serum DHT, compared with placebo (D, 94%; F, 73%) and transiently increased serum T. These effects were found to be reversible after discontinuation.
d. Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) they will slow or stop the cascade effect by blocking prostaglandin biosynthesis. Prostaglandin biosynthesis is vitally important to the synthesis of protein, which is needed for growth and repair of skeletal muscle.
To get optimal results from The One we recommend you employ the use some type of volume training regimen. Charles Poliquin’s German Volume Training program is an excellent example of it. The reason we recommend volume training is because it overloads the muscle with a large number of sets and reps, which is a strong stimulus for hypertrophy as well as fascial stretching. Overloading via increased volume causes a whole host of metabolic changes within skeletal muscle; it can increase local IGF-1 levels, protein synthesis, and mechano growth factor (MGF).
Volume training provides the impetus for a strong stretch reflex in skeletal muscle tissue- and by this allows for a whole host of anabolic stimuli to occur along with it. Couple this stimuli with the increased hormone levels from The One, and explosive growth will occur due to the resulting synergistic hormonal interactions.
Oddly, this is an area where we have seen the most variability and mistakes that can negatively impact results from taking The One. Fortunately, it’s also the easiest to fix. In short, you have to eat, and eat a lot! This product is a strong GLUT4 repartitioner, meaning that it can allow increased amounts of glycogen to be shuttled into skeletal muscle at a more rapid rate and in much larger amounts than normal. We recommend you do not attempt a low-carb regimen while on The One, but here’s the good news: You can still get lean while taking in those carbs! The One works in both an Androgen Receptor (AR) and non-AR mediated fashion, meaning that while it binds the AR strongly and exerts some of its effects through this interaction, it also exerts effects that are not directly based on AR stimulation. From what we have observed, the potency of these effects can largely be influenced by dietary Kcal and carbohydrate intake.
A quick rule of thumb is below. Those with a high metabolism should use the higher end of the scale, those with a slow metabolism, use the lower end. If you ingest these ranges in good clean healthy foods, it is all you’ll need.
Carbs: 1.5g – 3g / lb. of bodyweight
Protien: 1 – 1.5g / lb. of bodyweight
Fats: <100g / day
Am J Physiol Endocrinol Metab. 2008 May;294(5):E961-8. Epub 2008 Mar 1
Testosterone and DHEA activate the glucose metabolism-related signaling pathway in skeletal muscle.Sato K, Iemitsu M, Aizawa K, Ajisaka R.Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
The findings in this study suggest that skeletal muscle is capable of synthesizing DHT from testosterone, and that DHT activates the glucose metabolism-related signaling pathway in skeletal muscle cells.
So what does this mean? Keep your carbs and calories up. Even if you are trying to lose body fat while on this compound, you are in luck…you will lose body fat on The One (almost) regardless of what your total calorie intake is (again, within reason) because it does effect carbohydrate intake so strongly. This will also aid in increasing the already pre-existing increases in muscular volume and stretch from the volume training you are already partaking in, and further intensify these factors.
Certain supplements compliment The One very effectively, with Neovar and Omega Essentials being the two most important ones. Neovar increases local IGF-1 release and also GLUT4 translocation, and these two factors will act synergistically with some of the effects already incurred via The One.
Lastly, to help maintain overall health and a strong immune system, we recommend Bio-Mend, a powerful anti-oxidant that aids in cellular repair and Complete Balance, a full spectrum multi-vitamin.
We hope you have found this information useful and highly recommend you apply these principles to your cycle of The One. As always, we welcome individual questions which can be sent to email@example.com.
Stay tuned for the next posting that details the everything you need to know your post-cycle regimen, including taking 2nd Gear, training, diet, and other ancillary supplementation.
Thank you for your business!