Research Raloxifene

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  1. darius
    darius's Avatar

    Research Raloxifene


    Custom could you please get some research raloxifene?
    Last edited by size; 03-30-2005 at 01:24 PM.


  2. This is very interesting drug. It has lots of potential for research projects.
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  3. darius
    darius's Avatar

    Size, sorry about that, wasn't sure if I was crossing the line or not.

    Yeah it does look good. I want to try it out to get rid of my pubertal gyno. I am still not very sure if it's just fat or not, but I'm guessing it isn't. Rebound XT didn't do a whole lot for me. It may have been reduced some by it, but I'm guessing that was just the fat part due to the fat I'm shedding right now. There are some studies that show Raloxifene to be better than Tamoxifen for getting ridding of pubertal gyno.

    Does anyone know the differences between Nolva and Rebound XT? I may start a new thread asking this one.

  4. I've actually had a few requests for this, but had no time to look into it. I will send a few inquiries early next week.
  5. darius
    darius's Avatar

    Awesome . Thanks alot Custom.

    I don't see why it would be too impossible to get considering its like Nolva, only newer.

    A nice liquid suspension like the Nolva would be perfect for my mice.
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  6. I would be interested in this as well...

    I think if more people knew what it was, they would be interested too.

  7. I'm listening...

  8. custom how can i send u a PM or e-mail cause it says i cant!?? Wanted to know about getting some products from custom nutrition!

  9. bump for this.
  10. darius
    darius's Avatar

    bump

  11. Beleive it or not, I have not gotten any pricing back... I will sned out more inquiries.

  12. I've got some gyno from puberty as well. I haven't tried anything, but I'd definately be interested if it works.

    Maybe you need a tester?
  13. darius
    darius's Avatar

    Quote Originally Posted by custom
    Beleive it or not, I have not gotten any pricing back... I will sned out more inquiries.
    Thanks, although I'm really starting to believe that the gyno is just fat. Anyways, still interested. Thanks.

  14. Already spoke to you about this, but hey Ill bump anyways!

  15. Im intersted in research Raloxifen. Any word?

  16. i'll give a shout out
    whats the dillio, lets get some info.

  17. I should it within 20 days as they were currently out of stock.
  18. darius
    darius's Avatar

    You are THE MAN. God bless you Custom.

    I thought I was gonna have to risk ordering this **** from 3rd world countries.. thanks a bunch.

  19. Quote Originally Posted by custom
    I should it within 20 days as they were currently out of stock.
    Hey thats great...I appreciate you looking in to this...

  20. Looking for some good info on this stuff....Dar you and me seem to be on the same page on this issue....any suggestions?

  21. Seems like this is gonna happen............Excellent!
  22. darius
    darius's Avatar

    It would seem like a SERM like Raloxifene would be awesome for gyno related problems. A SERM is a selective estrogen receptor module that sits in the estrogen fitting receptor and prevents the estrogen to attach with it. I guess the breast has alot of those estrogen fitting receptors, and when estrogen attaches to those receptors, the cell then starts to grow and create more cells, thus creating bitch tits. Not exactly sure, but that is my present understanding.

    So Raloxifen is pretty similar to Tamoxifen (both SERMS), but studies indicate that Raloxifen is more successful at eliminating gyno. The other SERM that I know of is Toremifene, which should have similar effects like Ralo and Tamo. The Raloxifen would basically starve the gyno of estrogen, and it is to my understanding estrogen is what keeps the gyno alive. So keep away the estrogen, the gyno imo should stop growing for one, and two, should start getting smaller cause it will be starved of gyno. I'm guessing the length of time having the gyno and the size of it, determines how long one would have to "starve" it.

    Aromatase Inhibitors are different than SERM's, because instead of blocking the receptor, they lower the amount of estrogen that the body produces by "inhibiting the armatase". Those would be Arimidex, Letro, and Exmestane <--unmethylated Rebound XT. So those would be handy also in the anti-gyno stack.

    So in a way that is attacking it with two different ways. 1. Preventing estrogen from connecting with receptors to create gyno. 2. Lowering overall free floating estrogen in the body.

    There are some studes that show that DHT also can reduce gyno. Here for example from pubmed.com:

    "Eberle AJ, Sparrow JT, Keenan BS.

    Four boys with persistent pubertal gynecomastia were given intramuscular dihydrotestosterone heptanoate (DHT-hp) at 2 to 4-week intervals for 16 weeks. By the end of treatment, breast size in all four boys had decreased 67% to 78%. Initial plasma levels of gonadotropins, estradiol, testosterone, and dihydrotestosterone (DHT) were normal. Mean plasma DHT concentration rose with the injections of DHT-hp, and remained elevated throughout the treatment period. Estradiol, LH, FSH, and testosterone decreased during treatment, as did 24-hour urinary LH and FSH. No regrowth of breast tissue was observed 6 to 15 months after treatment, although hormone concentrations had returned to near pretreatment values by 2 months after the last injection. DHT-hp has potential to be an effective medical therapy for persistent pubertal gynecomastia."

    "Kuhn JM, Roca R, Laudat MH, Rieu M, Luton JP, Bricaire H.

    We have studied clinical and endocrine parameters in a group (group A) of forth men referred to us because of persistent idiopathic gynaecomastia (of more than 18 months duration), before and during the administration of percutaneous dihydrotestosterone (DHT). The endocrine parameters (testosterone (T), 17 beta-oestradiol (E2), DHT, gonadotrophins (FSH and LH) and prolactin (PRL), were compared to those of control groups of 12 healthy men on DHT therapy (group B) and 10 on placebo (group C). Local administration of DHT was followed by the complete disappearance of gynaecomastia in 10 patients, partial regression in 19 and no change in 11 patients after 4 to 20 weeks of percutaneous DHT (125 mg twice daily). Before treatment the T + DHT/E2 ratio was significantly (P less than 0.001) lower in group A 244 +/- 21 (SEM) than in groups B and C (361 +/- 21) while T, DHT and E2 concentrations were all within the normal range. During DHT treatment plasma hormone levels were measured in 26 patients from group A: DHT levels increases significantly (day 0: 1.63 +/- 0.14 nmol/l; day 15: 12.8 +/- 1.6 nmol/l, P less than 0.001) while T and E2 levels fell significantly (T: day 0: 22.6 +/- 1.2 nmol/l; day 15: 11.0 +/- 1.5 nmol/l, P less than 0.001; E2: day 0: 110.5 +/- 7.12 pmol/l; day 15: 86.79 +/- 9.4 pmol/l, P less than 0.01). The T/E2 ratio decreased from 231 +/- 20 to 164 +/- 27 (P less than 0.05) while the T + DHT/E2 ratio increased significantly (P less than 0.02) to a normal mean value (day 15: 354 +/- 57).(ABSTRACT TRUNCATED AT 250 WORDS)"

    So I have some imaginary 3-Alpa powder that will be mixed with Ab-Solved or its carrier whenever Avant Labs releases it. This will be the 3rd point of attack. What sucks is that I have male pattern baldness and the extra DHT will suck. I will use Azeleic Acid and Spiro topically to block the DHT at the scalp.

    I havent decided doses yet, but I will run all 3 together and hope for the best.
  23. darius
    darius's Avatar

    Just curious, is this going to be in liquid form? Any idea on pricing/serving size?

  24. It will be liquid, yes. The powder is not terribly expensive, but it is about 2.5 times more expensive to source than Nolva to give you an idea...on a selling price I am not sure yet. I am sure it will be the standard 50ml with 1 dose per ml.

  25. Awesome, thank you, boss.
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