Research Raloxifene

Page 2 of 3 First 123 Last
  1. New Member
    asap nutrition's Avatar
    Join Date
    May 2005
    Age
    32
    Posts
    387
    Rep Power
    311
    Level
    16
    Lv. Percent
    75.06%

    Yeah someone needs to get it and I rather it be custom. Soon as some gets it and charge a reasonable price then I am on it.

  2. the triumph of the grill
    kwantam's Avatar
    Join Date
    Jan 2005
    Age
    33
    Posts
    405
    Rep Power
    323
    Level
    16
    Lv. Percent
    83.58%

    bump?

    -kwantam
  3. Board Sponsor
    custom's Avatar
    Join Date
    Jun 2003
    Age
    36
    Posts
    3,971
    Rep Power
    13236
    Level
    44
    Lv. Percent
    92.11%
    Achievements Activity ProPosting Pro

    Still has not shipped as of Friday. Realistically, it may be a few more weeks.

    If, by Monday, they tell me it will be much longer I'll get my money back and order it through someone else.
    •   
       

  4. New Member
    asap nutrition's Avatar
    Join Date
    May 2005
    Age
    32
    Posts
    387
    Rep Power
    311
    Level
    16
    Lv. Percent
    75.06%

    Quote Originally Posted by custom
    Still has not shipped as of Friday. Realistically, it may be a few more weeks.

    If, by Monday, they tell me it will be much longer I'll get my money back and order it through someone else.
    Just keep us posted my friend.
  5. darius
    Guest
    darius's Avatar

    Any updates Custom?
  6. Elite Member
    DR.D's Avatar
    Stats
    6'0"  228 lbs.
    Join Date
    Dec 2003
    Posts
    6,780
    Rep Power
    307856
    Level
    56
    Lv. Percent
    45.7%
    Achievements Activity ProPosting ProPosting Authority

    Quote Originally Posted by NeedleDick
    Can't wait for it, does anyone know what the detection time for this is, would love
    to use it against gyno but if it lingers a little around like nolva, its a no go for me would appreciate any info thanks!
    Yeah, same detection time as Nolva.

    This may work well for gyno, but it's the PCT application that excites me! This is the only SERM that ever made me cream my jeans before. Strong stuff, but only 1/3 as toxic as Nolva.

    YES! Thanks Custom!!
  7. New Member
    momod's Avatar
    Join Date
    Apr 2005
    Age
    47
    Posts
    57
    Rep Power
    146
    Level
    7
    Lv. Percent
    0.16%

    Quote Originally Posted by darius
    I wouldn't expect fast results with this for gyno, maybe good reduction over a couple months.

    I think this has been said before but the only conclusive studies I have seen on gyno reduction for persistent pubertal gyno were trials that lasted close to 6 months. I think I will run the raloxifene in the same manner as the studies on pubmed that showed success. That is if I can stand not juicing for that long (-:. I kid of course!
  8. Professional Member
    size's Avatar
    Join Date
    Jan 2003
    Age
    42
    Posts
    4,232
    Rep Power
    2270
    Level
    44
    Lv. Percent
    93.32%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by DR.D
    This may work well for gyno, but it's the PCT application that excites me! This is the only SERM that ever made me cream my jeans before. Strong stuff, but only 1/3 as toxic as Nolva.

    I think it should work for gyno as well. The study below shows a better response than tamoxifen for gyno.

    Beneficial effects of raloxifene and tamoxifen in the treatment of pubertal gynecomastia.

    Lawrence SE, Faught KA, Vethamuthu J, Lawson ML.

    Department of Pediatrics, University of Ottawa, Ontario, Canada.
    OBJECTIVES: To assess the efficacy of the anti-estrogens tamoxifen and raloxifen in the medical management of persistent pubertal gynecomastia. STUDY DESIGN: Retrospective chart review of 38 consecutive patients with persistent pubertal gynecomastia who presented to a pediatric endocrinology clinic. Patients received reassurance alone or a 3- to 9-month course of an estrogen receptor modifier (tamoxifen or raloxifene). RESULTS: Mean (SD) age of treated subjects was 14.6 (1.5) years with gynecomastia duration of 28.3 (16.4) months. Mean reduction in breast nodule diameter was 2.1 cm (95% CI 1.7, 2.7, P <.0001) after treatment with tamoxifen and 2.5 cm (95% CI 1.7, 3.3, P <.0001) with raloxifene. Some improvement was seen in 86% of patients receiving tamoxifen and in 91% receiving raloxifene, but a greater proportion had a significant decrease (>50%) with raloxifene (86%) than tamoxifen (41%). No side effects were seen in any patients. CONCLUSION: Inhibition of estrogen receptor action in the breast appears to be safe and effective in reducing persistent pubertal gynecomastia, with a better response to raloxifene than to tamoxifen. Further study is required to determine that this is truly a treatment effect.


    just realized X_muslce already posted this. I added some color though.
  9. Advanced Member
    Enigma76's Avatar
    Join Date
    May 2004
    Age
    29
    Posts
    981
    Rep Power
    623
    Level
    24
    Lv. Percent
    34.11%

    Quote Originally Posted by DR.D
    Yeah, same detection time as Nolva.

    This may work well for gyno, but it's the PCT application that excites me! This is the only SERM that ever made me cream my jeans before. Strong stuff, but only 1/3 as toxic as Nolva.

    YES! Thanks Custom!!
    Since your the guru on this stuff (you're always pushing it as an alt to nolva) any guidelines for dosing?

    Similar scheme to nolva? Start high, taper down, 4 weeks?
  10. Professional Member
    size's Avatar
    Join Date
    Jan 2003
    Age
    42
    Posts
    4,232
    Rep Power
    2270
    Level
    44
    Lv. Percent
    93.32%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by Enigma76
    Since your the guru on this stuff (you're always pushing it as an alt to nolva) any guidelines for dosing?
    Similar scheme to nolva? Start high, taper down, 4 weeks?
    I think dosages may have to be worked around to find the proper scheme. I have read various studies where raloxifene dosages range from 50 to 200mg daily.


    For instance here is one where men received 120mg daily:
    Effects of raloxifene on gonadotrophins, sex hormones, bone turnover and lipids in healthy elderly men.
    Duschek EJ, Gooren LJ, Netelenbos C.
    Department of Endocrinology, VU University Medical Centre, Amsterdam, The Netherlands.

    OBJECTIVE: To explore effects on serum lipids, pituitary-gonadal axis, prostate and bone turnover of the administration of the mixed oestrogen agonist/antagonist raloxifene in healthy elderly men. PARTICIPANTS: Thirty healthy men aged 60-70 years randomly received raloxifene 120 mg/day (n=15) or placebo (n=15) for 3 months. MEASUREMENTS: In this double-blind, placebo-controlled study, serum gonadotrophins, sex hormones, prostate specific antigen (PSA), a marker of bone turnover, urinary hydroxyproline (OHPro) and cholesterol were measured at baseline and after 3 months. RESULTS: Raloxifene significantly increased serum concentrations of LH and FSH (by 29% and 21%), total testosterone (20%), free testosterone (16%) and bioavailable testosterone (not bound to sex hormone-binding globulin (SHBG; 20%). In parallel with testosterone, 17 beta-oestradiol also increased by 21%. SHBG increased by 7%. Total cholesterol (TChol) decreased significantly, from 5.7 to 5.5 mmol/l (P=0.03). Low-density lipoprotein cholesterol (LDL-c) and high-density lipoprotein cholesterol (HDL-c) showed a trend to decrease. Overall, there was no change in urinary OHPro/creatinine ratio as a marker for bone resorption. However, the raloxifene-induced increases in both serum testosterone and 17 beta-oestradiol were significantly related to a lower OHPro/creatinine ratio. Total PSA increased by 17% without significant changes in free PSA or free/total PSA ratio. Participants reported no side effects and raloxifene was well tolerated. CONCLUSION: In healthy elderly man, raloxifene 120 mg/day for 3 months increased LH, FSH and sex steroid hormones. Potentially beneficial effects were the small but significant decrease in TChol and the trend towards a decrease in LDL-c. Negative effects were the trend towards a decrease in HDL-c and the significant increase in serum PSA. A decrease in markers of bone resorption during raloxifene treatment was found only in men with relatively high increases in serum testosterone and 17 beta-oestradiol. Overall, there were no clear beneficial effects of administration of raloxifene to ageing men in this preliminary investigation.


    Then this one uses 60mg:
    Raloxifene to prevent gonadotropin-releasing hormone agonist-induced bone loss in men with prostate cancer: a randomized controlled trial.
    Smith MR, Fallon MA, Lee H, Finkelstein JS.
    Division of Hematology and Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

    GnRH agonists decrease bone mineral density and increase fracture risk in men with prostate cancer. Raloxifene increases bone mineral density in postmenopausal women, but its efficacy in hypogonadal men is not known. In a 12-month open-label study, men with nonmetastatic prostate cancer (n = 48) who were receiving a GnRH agonist were assigned randomly to raloxifene (60 mg/d) or no raloxifene. Bone mineral densities of the posteroanterior lumbar spine and proximal femur were measured by dual energy x-ray absorptiometry. Mean (+/-se) bone mineral density of the posteroanterior lumbar spine increased by 1.0 +/- 0.9% in men treated with raloxifene and decreased by 1.0 +/- 0.6% in men who did not receive raloxifene (P = 0.07). Bone mineral density of the total hip increased by 1.1 +/- 0.4% in men treated with raloxifene and decreased by 2.6 +/- 0.7% in men who did not receive raloxifene (P < 0.001). Similar between-group differences were observed in the femoral neck (P = 0.06) and trochanter (P < 0.001). In men receiving a GnRH agonist, raloxifene significantly increases bone mineral density of the hip and tends to increase bone mineral density of the spine.



    Now admittedly, these studies are not exactly the application that I think most on this board want to research.
    Last edited by size; 06-03-2005 at 04:55 PM.
  11. I am faster than 80% of all snakes
    Dwight Schrute's Avatar
    Stats
    6'1"  221 lbs.
    Join Date
    Nov 2002
    Age
    41
    Posts
    12,911
    Rep Power
    7019

    For the love of god could you please stop with the "Tamox is toxic" crap. Its ridiculous.
    For answers to board issues, read the Suggestion and News forum at the bottom of the main page.
  12. Elite Member
    DR.D's Avatar
    Stats
    6'0"  228 lbs.
    Join Date
    Dec 2003
    Posts
    6,780
    Rep Power
    307856
    Level
    56
    Lv. Percent
    45.7%
    Achievements Activity ProPosting ProPosting Authority

    Quote Originally Posted by Bobo
    For the love of god could you please stop with the "Tamox is toxic" crap. Its ridiculous.
    I'm just going to close my ears now. Lalalalalala

    Besides Bobo, those are the old days. Ral is here now so rejoyce! I can talk smack about Clomid and Nolva, but this one is clean as a whistle. Not only on paper, and it is more liver friendly than tam, but from my few PCT's using it too.
  13. Elite Member
    DR.D's Avatar
    Stats
    6'0"  228 lbs.
    Join Date
    Dec 2003
    Posts
    6,780
    Rep Power
    307856
    Level
    56
    Lv. Percent
    45.7%
    Achievements Activity ProPosting ProPosting Authority

    Quote Originally Posted by Enigma76
    Since your the guru on this stuff (you're always pushing it as an alt to nolva) any guidelines for dosing?

    Similar scheme to nolva? Start high, taper down, 4 weeks?
    Size gave some good, applicable reports. Not less than 120mg is my suggestion. Toremifene is the stronger of these two, and is the one I call an alternate to Nolva. But Raloxifene is similarly clean. 240mg is the highest I'd experiment with.
  14. darius
    Guest
    darius's Avatar

    Where is the Raloxifene?? I hate to sound like an annoying ass, but where the hell is the Raloxifene??
  15. Board Sponsor
    custom's Avatar
    Join Date
    Jun 2003
    Age
    36
    Posts
    3,971
    Rep Power
    13236
    Level
    44
    Lv. Percent
    92.11%
    Achievements Activity ProPosting Pro

    Tracking history
    Date and Time Status Location
    6/3/2005 7:17 pm Departing origin. Shanghai, China
    2:54 am Arrived at DHL facility. Shanghai, China
    6/2/2005 9:20 pm Picked Up by DHL.

    Now that I know it has actually shipped, it should not be long now...hopefully.

    I cant really complain much even if this was shipped a month late as the company selling me a single KG of this was a huge favor and pain for them to do.
  16. darius
    Guest
    darius's Avatar

    That is awesome, awesome news. Thank you so much Custom. Any idea on prices yet? And do you see yourself getting future shipments also?

    Again, thanks so much.
  17. darius
    Guest
    darius's Avatar

    Quote Originally Posted by DR.D
    Size gave some good, applicable reports. Not less than 120mg is my suggestion. Toremifene is the stronger of these two, and is the one I call an alternate to Nolva. But Raloxifene is similarly clean. 240mg is the highest I'd experiment with.
    What about a long term dosing scheme for purposes of getting rid of gyno? Like for 3 or more months of use. Does anyone know how much they were taking in that gyno reduction study?
  18. Board Sponsor
    custom's Avatar
    Join Date
    Jun 2003
    Age
    36
    Posts
    3,971
    Rep Power
    13236
    Level
    44
    Lv. Percent
    92.11%
    Achievements Activity ProPosting Pro

    If it sells well, then yeah, futire shipments are on. On price, I have not yet determined that...I'd like to see more info on dosing and duration of use so i am not unknowingly raping people with the price.
  19. darius
    Guest
    darius's Avatar

    I think Dr. D hit the nail on the head with his suggestion of 120mg a day.
  20. Advanced Member
    -2z-'s Avatar
    Stats
    5'9"  190 lbs.
    Join Date
    Jan 2004
    Age
    43
    Posts
    736
    Rep Power
    502
    Level
    21
    Lv. Percent
    89.04%

    So....does that mean you would start with 120mg and taper down? Maybe like 120/100/80/60.....or is 120 the low end?

    Either way...this sounds like a pretty nice PCT weapon.
  21. darius
    Guest
    darius's Avatar

    Theres going to have to be some experimenting on that part to figure it all out. At least we know its really safe though. In my "The Pill Book", it states that this is prescribed for osteoporosis in post menopausal women, at least originally it was. I think they are finding out now that it works well for breast cancer as well. I'm sure healthy individuals would not see any major bone strengthening however. It says Raloxifene reduces the reabsorption of bone in the bloodstream and slows the overall rate at which bone is broken down and receptors in bone. Also states that it reduces the rate at whicht he body makes cholesterol and other blood fats. It also states that Raloxifene is rapidly absorbed into the blood with only 2% of a 60mg tab making it into the blood. It seems very safe though, especially for men, because in test studies according to this book, women took as high as 600mg a day without any problems at all. Animals have taken up to 810 times the human dosage without problems as well.

    This really does seem like the best you can get for PCT.

    I think a "painless oral" version of this would be insanely awesome.. seriously.. someone needs to figure it out haha. 2% of a 60mg tab is 1.2mg, so that would be like injecting 2.4mg of this into your pet rat for Dr. D's recommendation of 120mg.

    Or maybe some sort of transdermal for the gyno?
  22. Professional Member
    size's Avatar
    Join Date
    Jan 2003
    Age
    42
    Posts
    4,232
    Rep Power
    2270
    Level
    44
    Lv. Percent
    93.32%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by custom
    If it sells well, then yeah, futire shipments are on. On price, I have not yet determined that...I'd like to see more info on dosing and duration of use so i am not unknowingly raping people with the price.
    I think a good dosage point will be 100mg.
  23. Elite Member
    DR.D's Avatar
    Stats
    6'0"  228 lbs.
    Join Date
    Dec 2003
    Posts
    6,780
    Rep Power
    307856
    Level
    56
    Lv. Percent
    45.7%
    Achievements Activity ProPosting ProPosting Authority

    Quote Originally Posted by -2z-
    So....does that mean you would start with 120mg and taper down? Maybe like 120/100/80/60.....or is 120 the low end?

    Either way...this sounds like a pretty nice PCT weapon.
    That looks effective, or maybe something like 120,120,60,30 depending on your response
  24. Board Sponsor
    custom's Avatar
    Join Date
    Jun 2003
    Age
    36
    Posts
    3,971
    Rep Power
    13236
    Level
    44
    Lv. Percent
    92.11%
    Achievements Activity ProPosting Pro
    Last edited by custom; 06-08-2005 at 05:15 PM.
  25. Professional Member
    size's Avatar
    Join Date
    Jan 2003
    Age
    42
    Posts
    4,232
    Rep Power
    2270
    Level
    44
    Lv. Percent
    93.32%
    Achievements Activity ProPosting Pro

    Good deal.
  26. New Member
    momod's Avatar
    Join Date
    Apr 2005
    Age
    47
    Posts
    57
    Rep Power
    146
    Level
    7
    Lv. Percent
    0.16%

    Here is a link to a some different studies on grown men, using 60mg per day.

    http://www.superiormuscle.com/vbulle...threadid=18861
  27. Throbbing Member
    spitboy's Avatar
    Join Date
    Mar 2005
    Age
    39
    Posts
    274
    Rep Power
    257
    Level
    14
    Lv. Percent
    90.64%

    I searched the forum and I see your policy on shipping.. but any chance of this making it to Canada? I promise not to complain about duties and taxes.
  28. Registered User
    Neuromancer's Avatar
    Join Date
    Feb 2004
    Age
    36
    Posts
    954
    Rep Power
    616
    Level
    24
    Lv. Percent
    79.85%

    Quote Originally Posted by custom
    Its now up...
    That is great, thank you custom!!!
    Last edited by Neuromancer; 06-08-2005 at 05:59 PM.
  29. Registered User
    JonesersRX7's Avatar
    Join Date
    Jan 2005
    Age
    32
    Posts
    1,487
    Rep Power
    864
    Level
    29
    Lv. Percent
    78.2%
    Achievements Posting Pro

    Awesome... will def be ordering this with my fish oil caps.
  30. Board Sponsor
    custom's Avatar
    Join Date
    Jun 2003
    Age
    36
    Posts
    3,971
    Rep Power
    13236
    Level
    44
    Lv. Percent
    92.11%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by spitboy
    I searched the forum and I see your policy on shipping.. but any chance of this making it to Canada? I promise not to complain about duties and taxes.
    Send me an email with what you were wanting to pick up.
  31. darius
    Guest
    darius's Avatar

    Awesome. Thanks alot Custom, I seriously appreciate this alot.
  32. darius
    Guest
    darius's Avatar

    Are there any ways to help absorption? How about if taken at night with my fish oil?
  33. Elite Member
    DR.D's Avatar
    Stats
    6'0"  228 lbs.
    Join Date
    Dec 2003
    Posts
    6,780
    Rep Power
    307856
    Level
    56
    Lv. Percent
    45.7%
    Achievements Activity ProPosting ProPosting Authority

    Quote Originally Posted by darius
    Are there any ways to help absorption? How about if taken at night with my fish oil?
    Cholestyramine (or any anionic resin) severly inhibits abs. So does ampicillin, but other common meds are compatable. Absolute bioavailability sucks (2%) so the oral absorbtion (60%) is not that crutial, but high fat meals do increase the Cmax by 28% and AUC by 16%. It might be worth consideration if the pre-systemic clearance wasn't so high. In other words, 2% of 60% is about the same as 2% of 70%, so don't knock yourself out trying to get some fat with it, but it doesn't hurt.
  34. darius
    Guest
    darius's Avatar

    Thanks Dr. D. Just curious, where did you learn all this stuff? Did you take college classes or just surf the net lol? Right now I am majoring in chemistry (going into pharmacy). Still in basics right now, but am looking forward for my year with organic chem.

    After pharm school, I wouldn't mind designing my own stuff too.
  35. Elite Member
    Matthew D's Avatar
    Join Date
    Oct 2002
    Posts
    5,014
    Rep Power
    0
    Level
    46
    Lv. Percent
    99.56%
    Achievements Activity ProPosting ProPosting Authority

    Organic is where you will learn a ton about the makeup of compounds. Just seems to take a while for it to sink in or at least it did for me..

    He who wished he would take another organic class
  36. Elite Member
    DR.D's Avatar
    Stats
    6'0"  228 lbs.
    Join Date
    Dec 2003
    Posts
    6,780
    Rep Power
    307856
    Level
    56
    Lv. Percent
    45.7%
    Achievements Activity ProPosting ProPosting Authority

    Quote Originally Posted by darius
    Thanks Dr. D. Just curious, where did you learn all this stuff? Did you take college classes or just surf the net lol? Right now I am majoring in chemistry (going into pharmacy). Still in basics right now, but am looking forward for my year with organic chem.

    After pharm school, I wouldn't mind designing my own stuff too.
    I majored in physics and minored in chem, but had a strong interest in endocrinology and medicinal chemistry since I was in high school. I learned it slowly over the years on my own basically, though it connects with my education somewhat. I have a whole wall full of books (pre-internet days) and taught myself most of what I know. Trial and error was often the only way to test my theories, but I almost killed myself over 100 times so I don't suggest that, now it's much easier to find obscure data on the net. I wish I had become a pharmacist too, I'd be making a lot more cash today! But just learn every chance you get and pursue your true interests and you'll pick it up over time. Take an eclectic approach to learning.
  37. New Member
    bigman420's Avatar
    Join Date
    Aug 2004
    Age
    34
    Posts
    244
    Rep Power
    248
    Level
    13
    Lv. Percent
    29.59%

    Quote Originally Posted by darius
    A nice liquid suspension like the Nolva would be perfect for my mice.
    you don't have to lie here
  38. Senior Member
    Beau's Avatar
    Join Date
    Jan 2005
    Posts
    2,873
    Rep Power
    854640
    Level
    50
    Lv. Percent
    48.12%
    Achievements Activity ProPosting Pro

    Would grapefruit juice have any positive impact on absorbsion or magnify its effect? Does anyone have a list of those herbs/compunds/etc. on which GFJ has apositive effect?
  39. darius
    Guest
    darius's Avatar

    Quote Originally Posted by bigman420
    you don't have to lie here
    Nah dude.. I got this mouse a few years ago. He's got a little bit of pubertal gyno that he really wants gone. That's all. He also likes the idea that this is going to be awesome for PCT. Damn, it makes me jealous that I'm not a mouse.

  40. Elite Member
    DR.D's Avatar
    Stats
    6'0"  228 lbs.
    Join Date
    Dec 2003
    Posts
    6,780
    Rep Power
    307856
    Level
    56
    Lv. Percent
    45.7%
    Achievements Activity ProPosting ProPosting Authority

    Quote Originally Posted by Beau
    Would grapefruit juice have any positive impact on absorbsion or magnify its effect? Does anyone have a list of those herbs/compunds/etc. on which GFJ has apositive effect?
    No. It can be taken without reguard to meals really. The list you want could be easily found with a simple Metacrawler search.
  

  
 

Similar Forum Threads

  1. Research payment
    By Pykee in forum Anabolics
    Replies: 4
    Last Post: 05-26-2003, 11:16 PM
  2. research article presentation
    By Beta BBer in forum General Chat
    Replies: 2
    Last Post: 05-22-2003, 06:37 PM
  3. if a research project crashes?
    By goes4ever in forum Anabolics
    Replies: 6
    Last Post: 05-12-2003, 11:26 AM
  4. Replies: 68
    Last Post: 04-06-2003, 01:43 PM
  5. *Anabolic Research Update*
    By YellowJacket in forum Anabolics
    Replies: 1
    Last Post: 02-05-2003, 10:04 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Log in
Log in