Research Raloxifene

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  1. Just got an email saying this will not ship until after the International Memorial Day which is lasts until May 8th. So that puts us in about the third week fo may to have it ready for sale.


  2. Thanks for the update, Custom.
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  3. Quote Originally Posted by custom
    Just got an email saying this will not ship until after the International Memorial Day which is lasts until May 8th. So that puts us in about the third week fo may to have it ready for sale.
    Who knew Christmas came so early this year? Very nice addition Custom, I can't wait.

  4. Quote Originally Posted by custom
    Just got an email saying this will not ship until after the International Memorial Day which is lasts until May 8th. So that puts us in about the third week fo may to have it ready for sale.


    bizzzzzzzzzzzzump

  5. Can't wait for it, does anyone know what the detection time for this is, would love
    to use it against gyno but if it lingers a little around like nolva, its a no go for me would appreciate any info thanks!
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  6. darius
    darius's Avatar

    bump

  7. Just got an email back after their holiday...apparently it is not ready for shipment yet which, obviously is not good, but since it is already paid for, erks me just a bit.

    I was told it should ship within 10 days.

  8. Do we think this will be better than Rebound at gyno reduction?

    Or will we have to wait for anecdotal reports?

  9. Quote Originally Posted by jmh80
    Do we think this will be better than Rebound at gyno reduction?

    Or will we have to wait for anecdotal reports?
    I have read a study or two that says it may work better than tamoxifen. And the results in the study seemed promising.
  10. darius
    darius's Avatar

    I wouldn't expect fast results with this for gyno, maybe good reduction over a couple months.

  11. Yeah someone needs to get it and I rather it be custom. Soon as some gets it and charge a reasonable price then I am on it.

  12. bump?

    -kwantam

  13. Still has not shipped as of Friday. Realistically, it may be a few more weeks.

    If, by Monday, they tell me it will be much longer I'll get my money back and order it through someone else.

  14. Quote Originally Posted by custom
    Still has not shipped as of Friday. Realistically, it may be a few more weeks.

    If, by Monday, they tell me it will be much longer I'll get my money back and order it through someone else.
    Just keep us posted my friend.
  15. darius
    darius's Avatar

    Any updates Custom?

  16. Quote Originally Posted by NeedleDick
    Can't wait for it, does anyone know what the detection time for this is, would love
    to use it against gyno but if it lingers a little around like nolva, its a no go for me would appreciate any info thanks!
    Yeah, same detection time as Nolva.

    This may work well for gyno, but it's the PCT application that excites me! This is the only SERM that ever made me cream my jeans before. Strong stuff, but only 1/3 as toxic as Nolva.

    YES! Thanks Custom!!

  17. Quote Originally Posted by darius
    I wouldn't expect fast results with this for gyno, maybe good reduction over a couple months.

    I think this has been said before but the only conclusive studies I have seen on gyno reduction for persistent pubertal gyno were trials that lasted close to 6 months. I think I will run the raloxifene in the same manner as the studies on pubmed that showed success. That is if I can stand not juicing for that long (-:. I kid of course!

  18. Quote Originally Posted by DR.D
    This may work well for gyno, but it's the PCT application that excites me! This is the only SERM that ever made me cream my jeans before. Strong stuff, but only 1/3 as toxic as Nolva.

    I think it should work for gyno as well. The study below shows a better response than tamoxifen for gyno.

    Beneficial effects of raloxifene and tamoxifen in the treatment of pubertal gynecomastia.

    Lawrence SE, Faught KA, Vethamuthu J, Lawson ML.

    Department of Pediatrics, University of Ottawa, Ontario, Canada.
    OBJECTIVES: To assess the efficacy of the anti-estrogens tamoxifen and raloxifen in the medical management of persistent pubertal gynecomastia. STUDY DESIGN: Retrospective chart review of 38 consecutive patients with persistent pubertal gynecomastia who presented to a pediatric endocrinology clinic. Patients received reassurance alone or a 3- to 9-month course of an estrogen receptor modifier (tamoxifen or raloxifene). RESULTS: Mean (SD) age of treated subjects was 14.6 (1.5) years with gynecomastia duration of 28.3 (16.4) months. Mean reduction in breast nodule diameter was 2.1 cm (95% CI 1.7, 2.7, P <.0001) after treatment with tamoxifen and 2.5 cm (95% CI 1.7, 3.3, P <.0001) with raloxifene. Some improvement was seen in 86% of patients receiving tamoxifen and in 91% receiving raloxifene, but a greater proportion had a significant decrease (>50%) with raloxifene (86%) than tamoxifen (41%). No side effects were seen in any patients. CONCLUSION: Inhibition of estrogen receptor action in the breast appears to be safe and effective in reducing persistent pubertal gynecomastia, with a better response to raloxifene than to tamoxifen. Further study is required to determine that this is truly a treatment effect.


    just realized X_muslce already posted this. I added some color though.

  19. Quote Originally Posted by DR.D
    Yeah, same detection time as Nolva.

    This may work well for gyno, but it's the PCT application that excites me! This is the only SERM that ever made me cream my jeans before. Strong stuff, but only 1/3 as toxic as Nolva.

    YES! Thanks Custom!!
    Since your the guru on this stuff (you're always pushing it as an alt to nolva) any guidelines for dosing?

    Similar scheme to nolva? Start high, taper down, 4 weeks?

  20. Quote Originally Posted by Enigma76
    Since your the guru on this stuff (you're always pushing it as an alt to nolva) any guidelines for dosing?
    Similar scheme to nolva? Start high, taper down, 4 weeks?
    I think dosages may have to be worked around to find the proper scheme. I have read various studies where raloxifene dosages range from 50 to 200mg daily.


    For instance here is one where men received 120mg daily:
    Effects of raloxifene on gonadotrophins, sex hormones, bone turnover and lipids in healthy elderly men.
    Duschek EJ, Gooren LJ, Netelenbos C.
    Department of Endocrinology, VU University Medical Centre, Amsterdam, The Netherlands.

    OBJECTIVE: To explore effects on serum lipids, pituitary-gonadal axis, prostate and bone turnover of the administration of the mixed oestrogen agonist/antagonist raloxifene in healthy elderly men. PARTICIPANTS: Thirty healthy men aged 60-70 years randomly received raloxifene 120 mg/day (n=15) or placebo (n=15) for 3 months. MEASUREMENTS: In this double-blind, placebo-controlled study, serum gonadotrophins, sex hormones, prostate specific antigen (PSA), a marker of bone turnover, urinary hydroxyproline (OHPro) and cholesterol were measured at baseline and after 3 months. RESULTS: Raloxifene significantly increased serum concentrations of LH and FSH (by 29% and 21%), total testosterone (20%), free testosterone (16%) and bioavailable testosterone (not bound to sex hormone-binding globulin (SHBG; 20%). In parallel with testosterone, 17 beta-oestradiol also increased by 21%. SHBG increased by 7%. Total cholesterol (TChol) decreased significantly, from 5.7 to 5.5 mmol/l (P=0.03). Low-density lipoprotein cholesterol (LDL-c) and high-density lipoprotein cholesterol (HDL-c) showed a trend to decrease. Overall, there was no change in urinary OHPro/creatinine ratio as a marker for bone resorption. However, the raloxifene-induced increases in both serum testosterone and 17 beta-oestradiol were significantly related to a lower OHPro/creatinine ratio. Total PSA increased by 17% without significant changes in free PSA or free/total PSA ratio. Participants reported no side effects and raloxifene was well tolerated. CONCLUSION: In healthy elderly man, raloxifene 120 mg/day for 3 months increased LH, FSH and sex steroid hormones. Potentially beneficial effects were the small but significant decrease in TChol and the trend towards a decrease in LDL-c. Negative effects were the trend towards a decrease in HDL-c and the significant increase in serum PSA. A decrease in markers of bone resorption during raloxifene treatment was found only in men with relatively high increases in serum testosterone and 17 beta-oestradiol. Overall, there were no clear beneficial effects of administration of raloxifene to ageing men in this preliminary investigation.


    Then this one uses 60mg:
    Raloxifene to prevent gonadotropin-releasing hormone agonist-induced bone loss in men with prostate cancer: a randomized controlled trial.
    Smith MR, Fallon MA, Lee H, Finkelstein JS.
    Division of Hematology and Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

    GnRH agonists decrease bone mineral density and increase fracture risk in men with prostate cancer. Raloxifene increases bone mineral density in postmenopausal women, but its efficacy in hypogonadal men is not known. In a 12-month open-label study, men with nonmetastatic prostate cancer (n = 48) who were receiving a GnRH agonist were assigned randomly to raloxifene (60 mg/d) or no raloxifene. Bone mineral densities of the posteroanterior lumbar spine and proximal femur were measured by dual energy x-ray absorptiometry. Mean (+/-se) bone mineral density of the posteroanterior lumbar spine increased by 1.0 +/- 0.9% in men treated with raloxifene and decreased by 1.0 +/- 0.6% in men who did not receive raloxifene (P = 0.07). Bone mineral density of the total hip increased by 1.1 +/- 0.4% in men treated with raloxifene and decreased by 2.6 +/- 0.7% in men who did not receive raloxifene (P < 0.001). Similar between-group differences were observed in the femoral neck (P = 0.06) and trochanter (P < 0.001). In men receiving a GnRH agonist, raloxifene significantly increases bone mineral density of the hip and tends to increase bone mineral density of the spine.



    Now admittedly, these studies are not exactly the application that I think most on this board want to research.
    Last edited by size; 06-03-2005 at 04:55 PM.

  21. For the love of god could you please stop with the "Tamox is toxic" crap. Its ridiculous.
    For answers to board issues, read the Suggestion and News forum at the bottom of the main page.

  22. Quote Originally Posted by Bobo
    For the love of god could you please stop with the "Tamox is toxic" crap. Its ridiculous.
    I'm just going to close my ears now. Lalalalalala

    Besides Bobo, those are the old days. Ral is here now so rejoyce! I can talk smack about Clomid and Nolva, but this one is clean as a whistle. Not only on paper, and it is more liver friendly than tam, but from my few PCT's using it too.

  23. Quote Originally Posted by Enigma76
    Since your the guru on this stuff (you're always pushing it as an alt to nolva) any guidelines for dosing?

    Similar scheme to nolva? Start high, taper down, 4 weeks?
    Size gave some good, applicable reports. Not less than 120mg is my suggestion. Toremifene is the stronger of these two, and is the one I call an alternate to Nolva. But Raloxifene is similarly clean. 240mg is the highest I'd experiment with.
  24. darius
    darius's Avatar

    Where is the Raloxifene?? I hate to sound like an annoying ass, but where the hell is the Raloxifene??

  25. Tracking history
    Date and Time Status Location
    6/3/2005 7:17 pm Departing origin. Shanghai, China
    2:54 am Arrived at DHL facility. Shanghai, China
    6/2/2005 9:20 pm Picked Up by DHL.

    Now that I know it has actually shipped, it should not be long now...hopefully.

    I cant really complain much even if this was shipped a month late as the company selling me a single KG of this was a huge favor and pain for them to do.
  26. darius
    darius's Avatar

    That is awesome, awesome news. Thank you so much Custom. Any idea on prices yet? And do you see yourself getting future shipments also?

    Again, thanks so much.
  27. darius
    darius's Avatar

    Quote Originally Posted by DR.D
    Size gave some good, applicable reports. Not less than 120mg is my suggestion. Toremifene is the stronger of these two, and is the one I call an alternate to Nolva. But Raloxifene is similarly clean. 240mg is the highest I'd experiment with.
    What about a long term dosing scheme for purposes of getting rid of gyno? Like for 3 or more months of use. Does anyone know how much they were taking in that gyno reduction study?

  28. If it sells well, then yeah, futire shipments are on. On price, I have not yet determined that...I'd like to see more info on dosing and duration of use so i am not unknowingly raping people with the price.
  29. darius
    darius's Avatar

    I think Dr. D hit the nail on the head with his suggestion of 120mg a day.

  30. So....does that mean you would start with 120mg and taper down? Maybe like 120/100/80/60.....or is 120 the low end?

    Either way...this sounds like a pretty nice PCT weapon.
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