Where's the acetyl resveratrol

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  1. Where's the acetyl resveratrol


    How's it coming along? Really looking forward to this. I would love to beta test


  2. Quote Originally Posted by unitas27 View Post
    How's it coming along? Really looking forward to this. I would love to beta test
    We are closer than you may think :-D. I will post a thread for beta testers very soon.

    This stuff is looking amazing!
    PharmD

  3. I would hate to be a tester for this
    ^^Reverse psychology
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  4. Quote Originally Posted by pmiller383 View Post
    I would hate to be a tester for this
    ^^Reverse psychology
    You and me both brotha... so yea can't wait!

  5. Acetyl Res? Cool. I say okay and yesplease. babababaump for more info..

  6. is it only for PCT or can be used alone ?

  7. Quote Originally Posted by thahotboy View Post
    is it only for PCT or can be used alone ?
    We are marketing it as a standalone but don't get me wrong it is going to be a magnificent addition to any PCT.

    We purposely didn't add any other ingredients to the formula in order to make it more versatile.
    PharmD
  8. Never enough
    EasyEJL's Avatar

    i'm itching on this too, just to save me some $ over the cost of taking 1g of resveratrol a day. I think its around $2 a day which irritates me.
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  9. Quote Originally Posted by EasyEJL View Post
    i'm itching on this too, just to save me some $ over the cost of taking 1g of resveratrol a day. I think its around $2 a day which irritates me.
    Yeah, Resveratrol is expensive right now and the bioavailability just isn't there. I see the price coming down a lot over the next couple of years though which is a great thing.

    You should see how amazing this stuff is though in the most recent studies.
    PharmD
  10. Never enough
    EasyEJL's Avatar

    Oh I know, thats why i'm willing to spend $2 a day to take a high dose to get some oral availability
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  11. Looking forward to trying this also, Anyone else get sleepy after taking resveratrol, if so just wondering what might cause this.

  12. I thought I was the only one. it makes sleepy, But it does not do that to my wife. Do you take the 50% herb or the 99% pure extract? the 50% will do that more then the pure 99% powder.


    Quote Originally Posted by morigu View Post
    Looking forward to trying this also, Anyone else get sleepy after taking resveratrol, if so just wondering what might cause this.

  13. Quote Originally Posted by IBE View Post
    I thought I was the only one. it makes sleepy, But it does not do that to my wife. Do you take the 50% herb or the 99% pure extract? the 50% will do that more then the pure 99% powder.
    Honestly, not sure what percentage in product I was taking.
    I have noticed high doses of pycnogenol have the same effect. I'm kinda screwy though, things that are supposed to make me sleepy usually don't work for me, melatonin = speed for me etc.

  14. I"m almost the same way. Caffeine does nothing but make me tired. I drink something with expresso and i damn near drop into a coma.

    On a side note I can't wait for this one to come out. WIth an increase in bioavailability and a drop in price I think a lot more bb's will venture into using this for PCT.

  15. Quote Originally Posted by jminis View Post
    On a side note I can't wait for this one to come out. WIth an increase in bioavailability and a drop in price I think a lot more bb's will venture into using this for PCT.
    Yea looks like a solid addition to the supplement world.
    The LORD is my rock, my fortress, and my savior; my God is my rock, in whom I find protection. He is my shield, the power that saves me, and my place of safety.-Psalm 18:2

  16. Thats a good question, where the hell is the Acetyl-Resveratrol?

  17. Quote Originally Posted by Rx Lift View Post
    Thats a good question, where the hell is the Acetyl-Resveratrol?
    Waiting on labels to print, don't you worry, it's coming! We might be doing a pre sale soon.
    PharmD

  18. Im quite excited also.For pct and general health this will be a VERY welcome addition to my supplement tackle box!


    Trust in the LORD with all your heart, And lean not on your own understanding; In all your ways acknowledge Him, And He shall direct your paths . Proverbs 3:5-6

  19. As Austin would say "Yeah Baby.......Yeah!"

  20. If you were going to use Resveratrol in a PCT how would the dosing be compared to just using it ed as a staple for general health?
    Muscle Pharm Rep

  21. This is just speculation based on various opinions I've read, but i believe health benefits are seen with a low dose, such as 250 mg of trans-resveratrol daily. I myself haven't noticed much with such a low dose, but in the long-term it should be very beneficial as an anti-cancer/ anti-aging supplement.

    For PCT, I was taking 1 gram daily of 98& trans-resveratrol with piperine for more bioavailabilty. I definately had more stamina and I could feel a marked improvment with libido after two weeks. I also dropped some boday fat, which was a nice side effect.

    Honestly, you will want to exceed 1 gram dialy of the 98& resveratrol or 2 grams of the 50% extract for a good PCT.

    With Ibe's new acetylated product coming, dosage can be smaller with much better bioavailabily. This is what I have been waiting for.

    Hope that helps.

  22. Quote Originally Posted by unitas27 View Post
    This is just speculation based on various opinions I've read, but i believe health benefits are seen with a low dose, such as 250 mg of trans-resveratrol daily. I myself haven't noticed much with such a low dose, but in the long-term it should be very beneficial as an anti-cancer/ anti-aging supplement.

    For PCT, I was taking 1 gram daily of 98& trans-resveratrol with piperine for more bioavailabilty. I definately had more stamina and I could feel a marked improvment with libido after two weeks. I also dropped some boday fat, which was a nice side effect.

    Honestly, you will want to exceed 1 gram dialy of the 98& resveratrol or 2 grams of the 50% extract for a good PCT.

    With Ibe's new acetylated product coming, dosage can be smaller with much better bioavailabily. This is what I have been waiting for.

    Hope that helps.
    This is very speculative. You can't go off of "oral dosages" because not only are they different for everyone but they differ depending on other substances that are taken along side it. The only true way to see whether something would work in the body is to know the molar amounts of it in that specific tissue. Studies go off of the molar quantities to gauge effectiveness. For instance some actions of resveratrol are effective in the 5 uM range while some are 10 times that. There are limited studies that state the molar quantities in tissues after specific orally administered dosages. It is also a little different for rats and humans which is why it is hard to take a lot away from that. What I can say is that the health benefits of resveratrol are very clearly stated and that this really could be the next big thing for big pharma.
    PharmD

  23. I don't know if Acetyl-Resveratrol is de-acetylated in vivo. I'd want to be certain that it is and activates SIRT1, among others. Sinclair's studies have shown that any deviation from the OH at the 4-position negated SIRT1 activity.
    Last edited by riskarb; 04-29-2008 at 10:30 PM.

  24. Quote Originally Posted by LakeMountD View Post
    Yeah, Resveratrol is expensive right now and the bioavailability just isn't there. I see the price coming down a lot over the next couple of years though which is a great thing.

    You should see how amazing this stuff is though in the most recent studies.

    You're confusing bioavailbility and conjugation. Plasma spikes are considerable, but it is quickly conjugated in the liver.

  25. Quote Originally Posted by riskarb View Post
    You're confusing bioavailbility and conjugation. Plasma spikes are considerable, but it is quickly conjugated in the liver.
    No I am not confusing them. Bioavailability is used to describe the fraction of an administered dose of unchanged drug that reaches the systemic circulation (def. straight from text). With that being said conjugation is simply the act of changing the molecule. Therefore when the more conjugation taking place the less bioavailability of the compound that is being administered. The quicker you make it through the first pass of the liver the better. We are hoping that due to the increased lipophilicity that the compound will absorb fast enough that it can reach systemic circulation in larger amounts than regular resveratrol. Esterase and other enzymes will still degrade it but it is also possible that it gets degraded back into trans-resveratrol (trihydroxy form) after first pass. There are actually a lot of pharmaceutical companies attempting to do the same thing.

    As for SIRT1 activation I have seen conflicting studies on it and at this point there just isn't enough information to say for sure that it is the only thing that is needed (4'-hydroxy). Plus, resveratrol has countless benefits that extend WELL beyond SIRT1 activation. In fact there are hundreds.
    PharmD

  26. This is something that I am going to have to try.

  27. A plasma spike is seen prior to first pass. Is it bioavailable?

    Sirtis had access to acetyl-resv and passed on it. As you know, there is virtually no in vitro activity with the acetyl form. Also, the acetyl is an NCE and therefore is not a natural product, rendering legal issues related to its sale.

  28. Quote Originally Posted by riskarb View Post
    A plasma spike is seen prior to first pass. Is it bioavailable?

    Sirtis had access to acetyl-resv and passed on it. As you know, there is virtually no in vitro activity with the acetyl form. Also, the acetyl is an NCE and therefore is not a natural product, rendering legal issues related to its sale.
    Honestly, I do not trust any of the in vitro studies. If you read through most of the in vitro studies, they come to find that action in the body is completely different. You are isolating the molecule from the rest of the body. For instance they will culture intestinal cells and then add resveratrol. This is a very small system and does not take into account the many other cell types and millions of enzymes. There are limited in vivo studies, yes, but we are just going by the research we have done. They passed on acetyl resveratrol not because it doesn't work but because the application they are using it for had better options. For instance, anti-tumor properties. Acetyl Resveratrol had anti-tumor properties slightly higher than regular Res, but trimethoxy res had anti-tumor properties 10 times higher than regular res. However, trimethoxy res had absolutely no antioxidant effects. You have to find a middle ground.
    PharmD

  29. Passed it on show me the research and also you are referring to the 4-acetyl not tri-acetyl and also yes tri-acetylreveratrol is found in food. the 4-acetyl is not..nuff said.



    Quote Originally Posted by riskarb View Post
    A plasma spike is seen prior to first pass. Is it bioavailable?

    Sirtis had access to acetyl-resv and passed on it. As you know, there is virtually no in vitro activity with the acetyl form. Also, the acetyl is an NCE and therefore is not a natural product, rendering legal issues related to its sale.

  30. Quote Originally Posted by LakeMountD View Post
    Honestly, I do not trust any of the in vitro studies.
    Don't trust it, why is that? It's likely cleaved intracellularly and active in vivo, but you don't have the data.

  31. Quote Originally Posted by IBE View Post
    Passed it on show me the research and also you are referring to the 4-acetyl not tri-acetyl and also yes tri-acetylreveratrol is found in food. the 4-acetyl is not..nuff said.
    My brother's fund was a seed/mezz investor in Sirtis. Are you suggesting that 501 is the tri-acetyl? Show you? A shame you're not privy to the data. 501 is not the tri-acetyl. It's micronized resveratrol in HPMC and DOSS.

  32. Are you even from this country? what the heck are you talking about? where in any of mine or LMD did we say anything about 501. stop putting words in my month. I suggest you back off before things get ugly.



    Quote Originally Posted by riskarb View Post
    My brother's fund was a seed/mezz investor in Sirtis. Are you suggesting that 501 is the tri-acetyl? Show you? A shame you're not privy to the data. 501 is not the tri-acetyl. It's micronized resveratrol in HPMC and DOSS.

  33. Quote Originally Posted by IBE View Post
    Are you even from this country? what the heck are you talking about? where in any of mine or LMD did we say anything about 501. stop putting words in my month. I suggest you back off before things get ugly.
    "Passed it on show me the research" Which is nearly indecipherable, but I mentioned that Sirtis passed on the acetyl.

    SIRTIS and SRT-501 you phucking twit. Sirtis owns the data on the acetyl and they passed in favor of 501. I don't expect you to understand what you're attempting to bring to market. It's not as though you've phucked up before...

    tren or epi, which is it?
    Last edited by riskarb; 04-30-2008 at 03:37 PM.

  34. attempting to bring to the market? I am bringing to the market, I know what 501 is jack ass but what the heck does that have to do with my product? I asked you to back what you are trying to say but instead you come back and call me twit? Do you know who you are dealing with? Did'nt I warn you to back off? don't come on my forum and try to start sh*t me buddy. where is that research I ask one more time?


    Quote Originally Posted by riskarb View Post
    "Passed it on show me the research" Which is nearly indecipherable, but I mentioned that Sirtis passed on the acetyl.

    SIRTIS and SRT-501 you phucking twit. Sirtis owns the data on the acetyl and they passed in favor of 501. I don't expect you to understand what you're attempting to bring to market. It's not as though you've phucked up before...

    tren or epi, which is it?

  35. Quote Originally Posted by IBE View Post
    attempting to bring to the market? I am bringing to the market, I know what 501 is jack ass but what the heck does that have to do with my product? I asked you to back what you are trying to say but instead you come back and call me twit? Do you know who you are dealing with? Did'nt I warn you to back off? don't come on my forum and try to start sh*t me buddy. where is that research I ask one more time?
    Or what, another internet threat? You're woefully out of your depth. Please hold the trenbolone in your tri-acetyl product. The fact that you can't get the data proves how pathetically small-time you are. I have no interest in showing you sh^t.

  36. I knew you did'nt know what you were talking about. you showed your motive by not being an aldult and keeping it science but instead you call me a twit and bring up epi. it was nice chatting with you now come back and see us you here.


    Quote Originally Posted by riskarb View Post
    Or what, another internet threat? You're woefully out of your depth. Please hold the trenbolone in your tri-acetyl product. The fact that you can't get the data proves how pathetically small-time you are. I have no interest in showing you sh^t.

  37. Quote Originally Posted by IBE View Post
    I knew you did'nt know what you were talking about. you showed your motive by not being an aldult and keeping it science but instead you call me a twit and bring up epi. it was nice chatting with you now come back and see us you here.
    My apologies for the "twit" comment. It was a typo; I meant to type "twat"

  38. Twit sounds better but what the hell is twat?



    Quote Originally Posted by riskarb View Post
    My apologies for the "twit" comment. It was a typo; I meant to type "twat"

  39. I don't know what the hell Riskarb is even talking about...
    Freedom means nothing here.

  40. Riskarb is it necessary to come in our forum and start this kind of childish stuff....now come on.If I came to your house and started crap with you wouldnt you get offended.If you say no I must call you a liar as weve just seen how easily you resort to acting rude.

    Luckily youre privy to this "top secret info" so that you can use it to act up? By the sounds of it youre just following others peoples MO.

    So please if you have these studies and not just second hand info post them.If not please just back off.Thank you.


    Trust in the LORD with all your heart, And lean not on your own understanding; In all your ways acknowledge Him, And He shall direct your paths . Proverbs 3:5-6
  

  
 

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