The olive oil experiment
- 03-26-2012, 08:53 AM
- 03-26-2012, 09:23 AM
- 03-26-2012, 11:20 AM
BACKGROUND: Mulberries are a traditional edible food used to treat
hepatic disease. The anti-obesity and hypolipidemic effects of mulberry water
extracts (MWE) have attracted increasing interest. In the present study, MWE
were assessed for their hepatic lipid-lowering potential when administered in
fatty acid overload conditions in HepG2 cells.
RESULTS: We found that MWE significantly reduced lipid accumulation,
suppressed fatty acid synthesis, and stimulated fatty acid oxidation.
Furthermore, MWE also inhibited acetyl coenzyme A carboxylase activities by
stimulating adenosine monophosphate-activated protein kinase (AMPK). MWE
attenuated the expression of sterol regulatory element-binding protein-1
(SREBP-1) and its target molecules, such as fatty acid synthase. Similar results
were also measured in the expressions of enzymes involved in triglyceride and
cholesterol biosyntheses including glycerol-3-phosphate acyltransferase,
3-hydroxy-3-methylglutaryl-CoA reductase, and SREBP-2. In contrast, the
lipolytic enzyme expression of peroxisome proliferator activated receptor α and
carnitine palmitoyltransferase-1 were increased.
CONCLUSIONS: Our study suggests that the hypolipidemic effects of MWE
occur via phosphorylation of AMPK and inhibition of lipid biosynthesis.
Therefore, the mulberry extract may be active in the prevention of fatty liver.
Copyright © 2011 Society of Chemical Industry
03-26-2012, 11:46 AM
I'll have to look into this coconut butter. At first I kind of liked EVCO, but now it instantly activates my gag reflex. And this is from someone who loves coconuts. I just can't put down straight oil, even EVOO. So this sounds right up my alley. Thanks for the tip, guys!
03-26-2012, 12:23 PM
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