[dsade]

First ingredient released is....High Potency Mangiferin

http://www.ncbi.nlm.nih.gov/pubmed/22038976

Mol Nutr Food Res. 2011 Dec;55(12):1809-18. doi: 10.1002/mnfr.201100392. Epub 2011 Oct 31.
Beneficial effects of mangiferin on hyperlipidemia in high-fat-fed hamsters.

Guo F, Huang C, Liao X, Wang Y, He Y, Feng R, Li Y, Sun C.
Source

Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, PR China.

Abstract

SCOPE:

Mangiferin, a natural polyphenol, has been shown to have hypolipidemic effect in rat and mouse. However, the mechanism of action is not well understood. This study was conducted to determine the effect and mechanism of action of mangiferin on hyperlipidemia induced in hamsters by a high-fat diet.
METHODS AND RESULTS:

Forty male hamsters were randomly assigned to normal control, high-fat control, and high fat with mangiferin (50 and 150 mg/kg BW) groups. Mangiferin treatment significantly decreased final body weight, liver weight and visceral fat-pad weight, serum triglyceride (TG) and total free fatty acid (FFA) concentrations, hepatic TG levels and hepatic and muscle total FFA contents. Mangiferin upregulated mRNA expression of peroxisome proliferator-activated receptor-α (PPAR-α), fatty acid translocase (CD36) and carnitine palmitoyltransferase 1 (CPT-1), but downregulated mRNA expression of sterol regulatory element-binding protein 1c (SREBP-1c), acetyl CoA carboxylase (ACC), acyl-CoA:diacylglycerol acyltransferase 2 (DGAT-2) and microsomal triglyceride transfer protein (MTP) in liver. Mangiferin also stimulated mRNA expression of PPAR-α, CD36, CPT-1 and lipoprotein lipase (LPL) in muscle.
CONCLUSIONS:

The results suggest that mangiferin may ameliorate hypertriglyceridemia partly by modulating the expression levels of genes involved in lipid oxidation and lipogenesis.
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


PMID:22038976 [PubMed - indexed for MEDLINE]

[3clipseGT]

Nice!!!!

[domore]

First ingredient released is....High Potency Mangiferin

http://www.ncbi.nlm.nih.gov/pubmed/22038976

Mol Nutr Food Res. 2011 Dec;55(12):1809-18. doi: 10.1002/mnfr.201100392. Epub 2011 Oct 31.
Beneficial effects of mangiferin on hyperlipidemia in high-fat-fed hamsters.

Guo F, Huang C, Liao X, Wang Y, He Y, Feng R, Li Y, Sun C.
Source

Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, PR China.

Abstract

SCOPE:

Mangiferin, a natural polyphenol, has been shown to have hypolipidemic effect in rat and mouse. However, the mechanism of action is not well understood. This study was conducted to determine the effect and mechanism of action of mangiferin on hyperlipidemia induced in hamsters by a high-fat diet.
METHODS AND RESULTS:

Forty male hamsters were randomly assigned to normal control, high-fat control, and high fat with mangiferin (50 and 150 mg/kg BW) groups. Mangiferin treatment significantly decreased final body weight, liver weight and visceral fat-pad weight, serum triglyceride (TG) and total free fatty acid (FFA) concentrations, hepatic TG levels and hepatic and muscle total FFA contents. Mangiferin upregulated mRNA expression of peroxisome proliferator-activated receptor-α (PPAR-α), fatty acid translocase (CD36) and carnitine palmitoyltransferase 1 (CPT-1), but downregulated mRNA expression of sterol regulatory element-binding protein 1c (SREBP-1c), acetyl CoA carboxylase (ACC), acyl-CoA:diacylglycerol acyltransferase 2 (DGAT-2) and microsomal triglyceride transfer protein (MTP) in liver. Mangiferin also stimulated mRNA expression of PPAR-α, CD36, CPT-1 and lipoprotein lipase (LPL) in muscle.
CONCLUSIONS:

The results suggest that mangiferin may ameliorate hypertriglyceridemia partly by modulating the expression levels of genes involved in lipid oxidation and lipogenesis.
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


PMID:22038976 [PubMed - indexed for MEDLINE]

And so it begins!

[metroba]

This looks very good. I cannot wait to see how the people respond to this. Almost looks like a tri-monthly staple, taken for 12 weeks .

[testosteronet]

I approve of the first ingredient, may I have another?

[dsade]

Carried over from original DCP...

Arch Pharm Res. 2012 Mar;35(3):481-6. doi: 10.1007/s12272-012-0311-8. Epub 2012 Apr 5.
Bioassay-guided isolation of fatty acid synthase inhibitory diterpenoids from the roots of Salvia miltiorrhiza Bunge.

Jang TS, Zhang H, Kim G, Kim DW, Min BS, Kang W, Son KH, Na M, Lee SH.
Source

College of Medicine, CHA University, Seoul 135-080, Korea.

Abstract

Fatty acid synthase (FAS) is considered as a novel drug target for the development of anticancer and anti-obesity agents. Bioassay-guided fractionation of a n-hexane-soluble extract prepared from the roots of Salvia miltiorrhiza Bunge (Labiatae), using an in vitro enzyme assay, led to the isolation of five abietane diterpenoids: 15,16-dihydrotanshinone I (1), cryptotanshinone (2), tanshinone I (3), tanshinone IIA (4), and dansenspiroketallactone (5). Compounds 1-5 were tested for their in vitro FAS inhibitory activity and, except for compound 5 (IC(50) > 100 μM), compounds 1-4 inhibited the enzyme activity with IC(50) values ranging from 12.0 to 30.3 μM. Our findings may be partially related to the anticancer activity of abietane diterpenoids from the plant, suggesting a further study on the anticancer potential of tanshinone derivatives.


PMID:22477195 [PubMed - indexed for MEDLINE]

[dsade]

Arch Pharm Res. 2002 Aug;25(4):446-8.
Inhibitory activity of diacylglycerol acyltransferase by tanshinones from the root of Salvia miltiorrhiza.

Ko JS, Ryu SY, Kim YS, Chung MY, Kang JS, Rho MC, Lee HS, Kim YK.
Source

Cardiovascular Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon.

Abstract

The inhibitory activity of tanshinones from Salvia miltiorrhiza was tested on rat liver diacylglycerol acyltransferase (DGAT). Cryptotanshinone (1) and 15,16-dihydrotanshinone I (3) exhibited potent DGAT inhibitory activities dose-dependently with IC50 values of 10.5 microg/ml and 11.1 microg/ml. However, tanshinone IIA (2) and tanshinone I (4) showed very weak inhibition (IC50 value: > 250 microg/ml). A dihydrofuran moiety was seemed to be responsible for the stronger inhibitory activity.


PMID:12214853 [PubMed - indexed for MEDLINE]

[dsade]

That's all for now....We still have around 3 weeks production time, and last thing we need is to be copied. Though, to be honest, we are taking a pretty small profit margin on this product to make sure you have the most badass, and affordable, Recomposition Ammunition we can make.

Most other companies wouldn't waste the time.

[testosteronet]

It's going to be a great summer!

[Dewey99]

That's all for now....We still have around 3 weeks production time, and last thing we need is to be copied. Though, to be honest, we are taking a pretty small profit margin on this product to make sure you have the most badass, and affordable, Recomposition Ammunition we can make.

Most other companies wouldn't waste the time.

Good stuff as always, Matt! I am a huge fan of your work and the original, so I am really looking forward to trying the new formula. I guess you could say I'm a fan:

[testosteronet]

That's a beautiful collage!

[dsade]

Good stuff as always, Matt! I am a huge fan of your work and the original, so I am really looking forward to trying the new formula. I guess you could say I'm a fan:

Now that's a stash!

[baldymcgee]

the real question is: which will be released first, cardiotryx or dcp ?

[dsade]

the real question is: which will be released first, cardiotryx or dcp ?

2 different brands, 2 different groups of people involved.

[taman6886]

Good stuff as always, Matt! I am a huge fan of your work and the original, so I am really looking forward to trying the new formula. I guess you could say I'm a fan:

da-amn!

[Resolve]

When a stash gets that big, it's a freaking investment - and with the way DCP goes out of stock, it's a good one, too.

[dsade]

J Med Food. 2012 May;15(5):495-503. doi: 10.1089/jmf.2011.1717.
Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitis.

Wang L, Meng X, Zhang F.
Source

College of Food, Shenyang Agricultural University, Shenyang, Liaoning, China.

Abstract

The protective effect of raspberry ketone against nonalcoholic steatohepatitis (NASH) was tested by using a high-fat diet-induced NASH model, and its mechanism was explored. Forty Sprague-Dawley rats with a 1:1 male to female ratio were randomly divided into five groups: the normal control (NC) group (n=8) fed normal diet for 8 weeks, the model control (MC) group (n=8) fed high-fat diet (82% standard diet, 8.3% yolk powder, 9.0% lard, 0.5% cholesterol, and 0.2% sodium taurocholate), and the raspberry ketone low-dose (0.5%) (RKL) group (n=8), the raspberry ketone middle-dose (1%) (RKM) group (n=8), and the raspberry ketone high-dose (2%) (RKH) group (n=8) fed high-fat diet for 4 weeks. After 8 weeks of experiment, all the rats were sacrificed, and blood lipid parameters (total cholesterol [TC], triglycerides [TG], high-density lipoprotein cholesterol [HDL-C], and low-density lipoprotein cholesterol [LDL-C]), liver function parameters (serum alanine aminotransferase [ALT], aspartate aminotransferase [AST], and alkaline phosphatase [ALP]), leptin (LEP), free fatty acid (FFA), tumor necrosis factor α (TNF-α), blood glucose (GLU), and insulin (INS) with calculated INS resistance index (IRI) and INS-sensitive index (ISI) were measured in rats. Therefore, we determined the peroxisome proliferator-activated receptor (PPAR)-α activity in liver homogenate and the levels of low-density lipoprotein receptor (LDLR), high-sensitivity C-reactive protein (hs-CRP), adiponection (APN), superoxide dismutase, and malondialdehyde (MDA). The liver tissues of rats in each group were imaged by electron microscopy with hematoxylin-eosin as the staining agent. The levels of TG, TC, LDL-C, ALT, AST, ALP, GLU, INS, IRI, FFA, LEP, TNF-α, MDA, and hs-CRP of MC rats were significantly increased (P<.05, P<.01). Therefore, the levels of HDL-C, ISI, PPAR-α, LDLR, and APN were significantly decreased (P<.05, P<.01). Compared with the MC group, each parameter in the RKL, RKM, and RKH groups was significantly improved (P<.05, P<.01). Thus raspberry ketone was an effective intervention for NASH in rats. It was believed that raspberry ketone had a dual effect of liver protection and fat reduction, and the mechanism was probably mediated by alleviation of fatty degeneration of liver cells, decreased liver inflammation, correction of dyslipidemia, reversal of LEP and INS resistance, and improved antioxidant capacity.


PMID:22551412 [PubMed - indexed for MEDLINE]
PMCID:PMC3338106 [Available on 2013/5/1]

[testosteronet]

Mangoes and Raspberries, oh my!

[EasyEJL]

Mangoes and Raspberries, oh my!

add some tequila and triple sec, and i'm set

[gkusa001]

U guys are killing me with this release date. Lol

[domore]

U guys are killing me with this release date. Lol

It is in production now. It should be around three weeks or so. Matt has said that the production process is very tedious.

[gkusa001]

Hey thanks for the heads up bro. I'll start saving up for it now. I'm really looking forward to it.

[testosteronet]

Hey thanks for the heads up bro. I'll start saving up for it now. I'm really looking forward to it.

I am looking very forward to it, too!

[domore]

Hey thanks for the heads up bro. I'll start saving up for it now. I'm really looking forward to it.

Not a problem. He just wants this to be done right.

[oufinny]

More delays, can't say I am surprised. Seems to be the norm lately with new product releases.

[dsade]

More delays, can't say I am surprised. Seems to be the norm lately with new product releases.

It's an extremely painstaking process, most of which is completely not under our control.

[oufinny]

It's an extremely painstaking process, most of which is completely not under our control.

This we are aware of as you are one of the few that actually admits that being the cause of the delay. My frustration is the early release of information when the product is nearly a quarter of a year away from being available. It's the name of the game, generate marketing buzz to sell more when it releases yada yada but it just makes people impatient it seems. Anyways, I am just curious what is in it and if it will work well for me.

[dsade]

This we are aware of as you are one of the few that actually admits that being the cause of the delay. My frustration is the early release of information when the product is nearly a quarter of a year away from being available. It's the name of the game, generate marketing buzz to sell more when it releases yada yada but it just makes people impatient it seems. Anyways, I am just curious what is in it and if it will work well for me.

Also my fault...sometimes my excitement gets the better of me. It has actually bit me in the ass a few times with copycats.

[MidwestBeast]

Also my fault...sometimes my excitement gets the better of me. It has actually bit me in the ass a few times with copycats.

There's a fine line with all of it (unfortunately). And I have to admit, I think it's cool when Matt gets as excited as he does about a product. With as much as he's formulated and researched over the years, you know it's good if he gets excited about it lol.

[ExciteBK]

Since there is no TTA, does this mean there is less chance of getting those wretched cramps? The original DCP crippled me, even with taurine, mag and potassium.