[Resolve]

So mean.

...but I chuckled

Wasn't directed at you, that was another 'fortune.' Probably the one I'd get, too, knowing my luck.

[MidwestBeast]

Wasn't directed at you, that was another 'fortune.' Probably the one I'd get, too, knowing my luck.

Oh I know it wasn't (though now I'm having second thoughts...uhhh....*runs away*). I just meant in general I know such a thing is mean, but I still laughed in the office when I read it. lol

[testosteronet]

"You're gonna need at least 2 bottles, Fatty"

Or...

"You are gonna need some Vanillean to go with this, Fatty"

[megadeth]

ETA?

[BPS]

ETA?

Very soon. Lots of progress made on it today.

[testosteronet]

I am eagerly awaiting the release of the new ingredient profile. Can't wait!

[jwa254]

Very soon. Lots of progress made on it today.

great news.

[Resolve]

I am eagerly awaiting the release of the new ingredient profile.

Aren't we all.

[jwa254]

Aren't we all.

Nope.

[oufinny]

Going on 10 weeks now...

[Resolve]

Going on 10 weeks now...

Good things come to those who wait

[testosteronet]

Good things come to those who wait

Yes, and patience is a virtue!

[dsade]

::insert cliche here:::

[megadeth]

Good things come to those who wait

and wait and wait and wait and wait and wait.....

[BPS]

Going on 10 weeks now...

Perfection takes time.

[dsade]

First ingredient released is....High Potency Mangiferin

http://www.ncbi.nlm.nih.gov/pubmed/22038976

Mol Nutr Food Res. 2011 Dec;55(12):1809-18. doi: 10.1002/mnfr.201100392. Epub 2011 Oct 31.
Beneficial effects of mangiferin on hyperlipidemia in high-fat-fed hamsters.

Guo F, Huang C, Liao X, Wang Y, He Y, Feng R, Li Y, Sun C.
Source

Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, PR China.

Abstract

SCOPE:

Mangiferin, a natural polyphenol, has been shown to have hypolipidemic effect in rat and mouse. However, the mechanism of action is not well understood. This study was conducted to determine the effect and mechanism of action of mangiferin on hyperlipidemia induced in hamsters by a high-fat diet.
METHODS AND RESULTS:

Forty male hamsters were randomly assigned to normal control, high-fat control, and high fat with mangiferin (50 and 150 mg/kg BW) groups. Mangiferin treatment significantly decreased final body weight, liver weight and visceral fat-pad weight, serum triglyceride (TG) and total free fatty acid (FFA) concentrations, hepatic TG levels and hepatic and muscle total FFA contents. Mangiferin upregulated mRNA expression of peroxisome proliferator-activated receptor-α (PPAR-α), fatty acid translocase (CD36) and carnitine palmitoyltransferase 1 (CPT-1), but downregulated mRNA expression of sterol regulatory element-binding protein 1c (SREBP-1c), acetyl CoA carboxylase (ACC), acyl-CoA:diacylglycerol acyltransferase 2 (DGAT-2) and microsomal triglyceride transfer protein (MTP) in liver. Mangiferin also stimulated mRNA expression of PPAR-α, CD36, CPT-1 and lipoprotein lipase (LPL) in muscle.
CONCLUSIONS:

The results suggest that mangiferin may ameliorate hypertriglyceridemia partly by modulating the expression levels of genes involved in lipid oxidation and lipogenesis.
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


PMID:22038976 [PubMed - indexed for MEDLINE]

[3clipseGT]

Nice!!!!

[domore]

First ingredient released is....High Potency Mangiferin

http://www.ncbi.nlm.nih.gov/pubmed/22038976

Mol Nutr Food Res. 2011 Dec;55(12):1809-18. doi: 10.1002/mnfr.201100392. Epub 2011 Oct 31.
Beneficial effects of mangiferin on hyperlipidemia in high-fat-fed hamsters.

Guo F, Huang C, Liao X, Wang Y, He Y, Feng R, Li Y, Sun C.
Source

Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, PR China.

Abstract

SCOPE:

Mangiferin, a natural polyphenol, has been shown to have hypolipidemic effect in rat and mouse. However, the mechanism of action is not well understood. This study was conducted to determine the effect and mechanism of action of mangiferin on hyperlipidemia induced in hamsters by a high-fat diet.
METHODS AND RESULTS:

Forty male hamsters were randomly assigned to normal control, high-fat control, and high fat with mangiferin (50 and 150 mg/kg BW) groups. Mangiferin treatment significantly decreased final body weight, liver weight and visceral fat-pad weight, serum triglyceride (TG) and total free fatty acid (FFA) concentrations, hepatic TG levels and hepatic and muscle total FFA contents. Mangiferin upregulated mRNA expression of peroxisome proliferator-activated receptor-α (PPAR-α), fatty acid translocase (CD36) and carnitine palmitoyltransferase 1 (CPT-1), but downregulated mRNA expression of sterol regulatory element-binding protein 1c (SREBP-1c), acetyl CoA carboxylase (ACC), acyl-CoA:diacylglycerol acyltransferase 2 (DGAT-2) and microsomal triglyceride transfer protein (MTP) in liver. Mangiferin also stimulated mRNA expression of PPAR-α, CD36, CPT-1 and lipoprotein lipase (LPL) in muscle.
CONCLUSIONS:

The results suggest that mangiferin may ameliorate hypertriglyceridemia partly by modulating the expression levels of genes involved in lipid oxidation and lipogenesis.
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


PMID:22038976 [PubMed - indexed for MEDLINE]

And so it begins!

[metroba]

This looks very good. I cannot wait to see how the people respond to this. Almost looks like a tri-monthly staple, taken for 12 weeks .

[testosteronet]

I approve of the first ingredient, may I have another?

[dsade]

Carried over from original DCP...

Arch Pharm Res. 2012 Mar;35(3):481-6. doi: 10.1007/s12272-012-0311-8. Epub 2012 Apr 5.
Bioassay-guided isolation of fatty acid synthase inhibitory diterpenoids from the roots of Salvia miltiorrhiza Bunge.

Jang TS, Zhang H, Kim G, Kim DW, Min BS, Kang W, Son KH, Na M, Lee SH.
Source

College of Medicine, CHA University, Seoul 135-080, Korea.

Abstract

Fatty acid synthase (FAS) is considered as a novel drug target for the development of anticancer and anti-obesity agents. Bioassay-guided fractionation of a n-hexane-soluble extract prepared from the roots of Salvia miltiorrhiza Bunge (Labiatae), using an in vitro enzyme assay, led to the isolation of five abietane diterpenoids: 15,16-dihydrotanshinone I (1), cryptotanshinone (2), tanshinone I (3), tanshinone IIA (4), and dansenspiroketallactone (5). Compounds 1-5 were tested for their in vitro FAS inhibitory activity and, except for compound 5 (IC(50) > 100 μM), compounds 1-4 inhibited the enzyme activity with IC(50) values ranging from 12.0 to 30.3 μM. Our findings may be partially related to the anticancer activity of abietane diterpenoids from the plant, suggesting a further study on the anticancer potential of tanshinone derivatives.


PMID:22477195 [PubMed - indexed for MEDLINE]

[dsade]

Arch Pharm Res. 2002 Aug;25(4):446-8.
Inhibitory activity of diacylglycerol acyltransferase by tanshinones from the root of Salvia miltiorrhiza.

Ko JS, Ryu SY, Kim YS, Chung MY, Kang JS, Rho MC, Lee HS, Kim YK.
Source

Cardiovascular Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon.

Abstract

The inhibitory activity of tanshinones from Salvia miltiorrhiza was tested on rat liver diacylglycerol acyltransferase (DGAT). Cryptotanshinone (1) and 15,16-dihydrotanshinone I (3) exhibited potent DGAT inhibitory activities dose-dependently with IC50 values of 10.5 microg/ml and 11.1 microg/ml. However, tanshinone IIA (2) and tanshinone I (4) showed very weak inhibition (IC50 value: > 250 microg/ml). A dihydrofuran moiety was seemed to be responsible for the stronger inhibitory activity.


PMID:12214853 [PubMed - indexed for MEDLINE]

[dsade]

That's all for now....We still have around 3 weeks production time, and last thing we need is to be copied. Though, to be honest, we are taking a pretty small profit margin on this product to make sure you have the most badass, and affordable, Recomposition Ammunition we can make.

Most other companies wouldn't waste the time.

[testosteronet]

It's going to be a great summer!

[Dewey99]

That's all for now....We still have around 3 weeks production time, and last thing we need is to be copied. Though, to be honest, we are taking a pretty small profit margin on this product to make sure you have the most badass, and affordable, Recomposition Ammunition we can make.

Most other companies wouldn't waste the time.

Good stuff as always, Matt! I am a huge fan of your work and the original, so I am really looking forward to trying the new formula. I guess you could say I'm a fan: