DCP and Ketogenesis

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For those following a Keto diet, DCP is an indispensible tool.
Diacylglycerol acyltransferase-1 inhibition enha... [J Lipid Res. 2013] - PubMed - NCBI


J Lipid Res. 2013 May;54(5):1369-84. doi: 10.1194/jlr.M035154. Epub 2013 Feb 28.
[h=1]Diacylglycerol acyltransferase-1 inhibition enhances intestinal fatty acid oxidation and reduces energy intake in rats.[/h]Schober G[SUP]1[/SUP], Arnold M, Birtles S, Buckett LK, Pacheco-López G, Turnbull AV, Langhans W, Mansouri A.
[h=3]Author information [/h]
[h=3]Abstract[/h]Acyl CoA:diacylglycerol acyltransferase-1 (DGAT-1) catalyzes the final step in triacylglycerol (TAG) synthesis and is highly expressed in the small intestine. Because DGAT-1 knockout mice are resistant to diet-induced obesity, we investigated the acute effects of intragastric (IG) infusion of a small molecule diacylglycerol acyltransferase-1 inhibitor (DGAT-1i) on eating, circulating fat metabolites, indirect calorimetry, and hepatic and intestinal expression of key fat catabolism enzymes in male rats adapted to an 8 h feeding-16 h deprivation schedule. Also, the DGAT-1i effect on fatty acid oxidation (FAO) was investigated in enterocyte cell culture models. IG DGAT-1i infusions reduced energy intake compared with vehicle in high-fat diet (HFD)-fed rats, but scarcely in chow-fed rats. IG DGAT-1i also blunted the postprandial increase in serum TAG and increased β-hydroxybutyrate levels only in HFD-fed rats, in which it lowered the respiratory quotient and increased intestinal, but not hepatic, protein levels of Complex III of the mitochondrial respiratory chain and of mitochondrial hydroxymethylglutaryl-CoA synthase. Finally, the DGAT-1i enhanced FAO in CaCo2 (EC50 = 0.3494) and HuTu80 (EC50 = 0.00762) cells. Thus, pharmacological DGAT-1 inhibition leads to an increase in intestinal FAO and ketogenesis when dietary fat is available. This may contribute to the observed eating-inhibitory effect.


PMID:23449193 [PubMed - indexed for MEDLINE]
PMCID:pMC3622331
 
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COmbined with the PPAR-a activation by Catalposide...

PLoS One. 2013 Sep 17;8(9):e74869. doi: 10.1371/journal.pone.0074869. eCollection 2013.
[h=1]Possible role of intestinal fatty acid oxidation in the eating-inhibitory effect of the PPAR-α agonist Wy-14643 in high-fat diet fed rats.[/h]Karimian Azari E[SUP]1[/SUP], Leitner C, Jaggi T, Langhans W, Mansouri A.
[h=3]Author information [/h]
[h=3]Abstract[/h]PPAR-α plays a key role in lipid metabolism; it enhances fatty acid oxidation (FAO) and ketogenesis. Pharmacological PPAR-α activation improves insulin sensitivity and reduces food intake, but its mechanisms of action remain unknown. We here report that intraperitoneal (IP) administration of the PPAR-α agonist Wy-14643 (40 mg/kg BW) reduced food intake in adult male rats fed a high-fat diet (HFD, 49% of the energy) mainly through an increase in the latency to eat after injection, and without inducing a conditioned taste avoidance. Also, IP administered Wy-14643 caused an acute (the first 60 min) decrease in the respiratory quotient (RQ) and an increase in hepatic portal vein β-hydroxybutyrate level (at 35 min) without affecting plasma non-esterified fatty acids. Given the known stimulatory effect of PPAR-α on FAO and ketogenesis, we measured the protein expression level of carnitine palmitoyltransferase-1 (CPT 1A) and mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme A synthase (HMG-CoAS2), two key enzymes for FAO and ketogenesis, respectively, in liver, duodenum and jejunum. Wy-14643 induced a significant increase in the expression of CPT 1A in the jejunum and duodenum and of HMG-CoAS2 in the jejunum, but neither CPT 1A nor HMG-CoAS2 expression was increased in the liver. The induction of CPT 1A and HMG-CoAS2 expression was associated with a decrease in the lipid droplet content selectively in the jejunum. Our findings indicate that Wy-14643 stimulates FAO and ketogenesis in the intestine, in particular in the jejunum, rather than in the liver, thus supporting the hypothesis that PPAR-α activation inhibits eating by stimulating intestinal FAO.


PMID:24069361 [PubMed - indexed for MEDLINE]
PMCID:pMC3775792
 
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Great information here. Might try the keto diet again in a couple months.

Would adding Vanillean help?
 
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Vanillean will help you burn off the circulating Free Fatty Acids MUCH more quickly. COmbustion would also be a good choice.
 
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Okay, you sold me! Those 3 with the keto diet. Just might log it.
 
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Okay, you sold me! Those 3 with the keto diet. Just might log it.
I'm working on a product right now for use right before sleep called KetoInduce. Provided you control your carb intake for the few hours before bed, it should hasten your entry into ketogenesis during sleep...but we have a few months before that's ready.
 
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I'm working on a product right now for use right before sleep called KetoInduce. Provided you control your carb intake for the few hours before bed, it should hasten your entry into ketogenesis during sleep...but we have a few months before that's ready.
Have I ever told you that I love you? No homo.
 
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