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AZMIDLYF

AZMIDLYF

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Ok I'm going to bite. Lol
 
metroba

metroba

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What a tease.
 
oufinny

oufinny

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What kind of tease is that???
 
metroba

metroba

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The kind that makes your nads blue.
 
metroba

metroba

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Lol not gonna say :D. You guys will be pleasantly surprised though. We are very excited about it.
 
Ape McGrapes

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In for write up in a week. BRB then...
 
packers6211

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Oh crap another suspense thread gona make me addicted. Anything BPS puts out I'm game for!
 
AZMIDLYF

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So when does another carrot get dangled??
 
andrew732

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yeah that GIF is awesome LOL!
 
oufinny

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Man I want to know what this is!
 
dsade

dsade

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BUMP
 
murk01

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U guys are really stepping up the production line!
 
andrew732

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Is there an ETA for this yet?
 
AZMIDLYF

AZMIDLYF

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Do we even know what it is yet?
 
AZMIDLYF

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9_1Comedian_Rodney_Dangerfield_1987.jpg
 
AZMIDLYF

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oufinny

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There best be some version of yohimbe in there; this guy is a fan of it.
 
prld2gr8ns

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There best be some version of yohimbe in there; this guy is a fan of it.
There seems to be a growing trend of Including Y in a lot of new formulated fat burners. I'm one of the folks that will not touch it with a 10 ft pole. To each there own though, it good at what it does.
 

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There seems to be a growing trend of Including Y in a lot of new formulated fat burners. I'm one of the folks that will not touch it with a 10 ft pole. To each there own though, it good at what it does.
I eat too often for Y to have a large enough effect. Unfortunate...
 
oufinny

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I eat too often for Y to have a large enough effect. Unfortunate...
Doing intermittent fasting Y-HCL is awesome for fasted AM cardio, melts the belly fat.
 
AZMIDLYF

AZMIDLYF

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I'm still trying to figure out the whole vanilla angle. Lol
 
BPS

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Evodiamine inhibits adipogenesis via the EGFR-PKCalpha-ERK signaling pathway.
Wang T, Wang Y, Yama****a H.
Source

Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai 487-8501, Japan.
Abstract

The molecular mechanism of the anti-adipogenic effect of evodiamine (which has several capsaicin-like pharmacological actions) was investigated. The evodiamine effect was not blocked by the specific TRPV1 antagonist capsazepine in 3T3-L1 preadipocytes, whereas its effect was greatly curtailed by inhibitors of protein kinase C (PKC) and epidermal growth factor receptor (EGFR). Signal analyses showed that evodiamine stimulated the phosphorylation of EGFR, PKCalpha, and ERK, all of which were reduced by an EGFR inhibitor. Silencing experiments of EGFR mRNA supported the involvement of these signaling molecules in the inhibitory effect of evodiamine. An unidentified mechanism whereby evodiamine inhibits adipogenesis via the EGFR-PKCalpha-ERK signaling pathway was revealed.

PMID:



19854188



[PubMed - indexed for MEDLINE]
 
BPS

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Activation of TRPV1 and TRPA1 by black pepper components.
Okumura Y, Narukawa M, Iwasaki Y, Ishikawa A, Matsuda H, Yoshikawa M, Watanabe T.
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Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizouka, Japan.
Abstract

We searched in this study for novel agonists of transient receptor potential cation channel, subfamily V, member 1 (TRPV1) and transient receptor potential cation channel, subfamily A, member 1 (TRPA1) in pepper, focusing attention on 19 compounds contained in black pepper. Almost all the compounds in HEK cells heterogeneously expressed TRPV1 or TRPA1, increased the intracellular Ca(2+) concentration ([Ca(2+)](i)) in a concentration-dependent manner. Among these, piperine, isopiperine, isochavicine, piperanine, pipernonaline, dehydropipernonaline, retrofractamide C, piperolein A, and piperolein B relatively strongly activated TRPV1. The EC(50) values of these compounds for TRPV1 were 0.6-128 microM. Piperine, isopiperine, isochavicine, piperanine, piperolein A, piperolein B, and N-isobutyl-(2E,4E)-tetradeca-2,4-diamide also relatively strongly activated TRPA1, the EC(50) values of these compounds for TRPA1 were 7.8-148 microM. The Ca(2+) responses of these compounds for TRPV1 and TRPA1 were significantly suppressed by co-applying each antagonist. We identified in this study new transient receptor potential (TRP) agonists present in black pepper and found that piperine, isopiperine, isochavicine, piperanine, piperolein A, and piperolein B activated both TRPV1 and TRPA1.

PMID:



20460725



[PubMed - indexed for MEDLINE]
 
AZMIDLYF

AZMIDLYF

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Any Raspberry Ketones involved as well?
 
Piston Honda

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Evodiamine inhibits adipogenesis via the EGFR-PKCalpha-ERK signaling pathway.
Wang T, Wang Y, Yama****a H.
Source

Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai 487-8501, Japan.
Abstract

The molecular mechanism of the anti-adipogenic effect of evodiamine (which has several capsaicin-like pharmacological actions) was investigated. The evodiamine effect was not blocked by the specific TRPV1 antagonist capsazepine in 3T3-L1 preadipocytes, whereas its effect was greatly curtailed by inhibitors of protein kinase C (PKC) and epidermal growth factor receptor (EGFR). Signal analyses showed that evodiamine stimulated the phosphorylation of EGFR, PKCalpha, and ERK, all of which were reduced by an EGFR inhibitor. Silencing experiments of EGFR mRNA supported the involvement of these signaling molecules in the inhibitory effect of evodiamine. An unidentified mechanism whereby evodiamine inhibits adipogenesis via the EGFR-PKCalpha-ERK signaling pathway was revealed.

PMID:



19854188



[PubMed - indexed for MEDLINE]
I remember trying Redline RTDs 5 or 6 years ago and that stuff was unbelievable. Best stim-rush ever, but I remember seeing evodiamine on the ingredient panel and wondered at the time if that was the medical name for liquid crack.
 
MrKleen73

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Well I can only say that from what I am reading Vanillean doesn't have any of the "usual suspects". Sounds anything but "Vanilla" to me!
 
oufinny

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Well I can only say that from what I am reading Vanillean doesn't have any of the "usual suspects". Sounds anything but "Vanilla" to me!
Granted we know as much as you guys do, Vanillean should be very different and very new. I have never questioned BPS because everything does what it says, I can only imagine Vanillean will be yet another great product.
 
andrew732

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Yes I agree that BPS is a straight shooter company.
 

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