Originally Posted by strategicmove

This is not a trivial question. Before I attempt an answer, I would like to insist that any individual with a known case of Type-2 diabetes should take any supplements only in consultation with a qualified medical personnel. In what follows, I will desist from making a recommendation. Rather, I will try to clarify why I think the response to your question is non-trivial, especially in the interest of those not conversant with Type-2 diabetes. I will aim to keep my response short.

There are two types of diabetic conditions, Type 1 and Type 2. Type 1 is generally regarded as an autoimmune disease. In an autoimmune disease, due to a dysfunction in the signalling network, the body attacks its own cells and organs, regarding them erroneously as foreign bodies. In the case of Type 1 diabetes, the body attacks the beta cells responsible for the manufacture of insulin. Consequently, Type-1 diabetics are unable to manufacture insulin and would need insulin replacements throughout their life time.

Type-2 diabetes, on the other hand, arises when the body is unable to utilize insulin effectively over time, leading to a condition known as insulin resistance. Here, the problem is not an inability of the body to manufacture insulin. Quite the contrary. In the beginning stages, the Type-2 diabetic experiences both hyperglycemia and hyperinsulinemia, as blood levels of insulin and glucose remain high, due to the body's inability to utilize insulin effectively. Why is this the case? In the early stages, insulin receptors show resistance to insulin, and because insulin is secreted by the pancreas to transport glucose into muscle and liver cells to be stored as glycogen, and into adipose tissue to be stored as fat reserves, glucose disposal is hindered due to this insulin insensitivity. This causes blood glucose levels to rise. The rise in blood glucose levels serves as a signal for the pancreas to secrete even more insulin to help dispose the rising blood glucose levels. This massive insulin surge can dispose some glucose, but leads to a significant increase in insulin concentration in the blood (hyperinsulinemia) in the presence of high blood glucose (hyperglycemia). This cycle of pancreatic secretion of insulin and insulin-receptor insensitivity in the presence of high glucose levels continues until the mature stage of the disease is reached, where the pancreas more or less self-destructs, producing very little insulin. This dramatically reduced levels of insulin means that glucose disposal cannot take place in any meaningful sense, leading to elevated levels of blood glucose in the presence of minute amounts of insulin. In other words, in this mature stage, hyperglycemia remains, while hypoinsulinemia sets in.

The qualitative differences between the early and subsequent stages of Type-2 diabetes means that the treatment options must be tailored accordingly.

Having summarized those key differences, it may now be said that because of elevated insulin and glucose levels in the early stages of Type-2 diabetes, compounds (such as corosolic acid in Anabolic Pump and P-Slin) that are known to trigger massive glucose disposal, independent of insulin, via stimulation of the glucose-transport protein, GLUT-4, are likely to be of immense benefit. This is because such compounds would force-drive the circulating glucose into muscle cells, ultimately reducing or reversing the condition of hyperglycemia. Once this is achieved, insulin receptors may begin to regain their sensitivity to insulin, ultimately leading to less secretion of insulin by the pancreas. This may, at the very least, stop the aggravation of the hyperinsulinemic condition, even leading to its reversal. So, Anabolic Pump and P-Slin may have their application in the early stages of Type-2, under the supervision of a qualified medical personnel.

How about during the subsequent stages characterized by hypoinsulinemia and hyperglycemia? Anabolic Pump and P-Slin can still find application here. Since they work independently of insulin, they can address the hyperglycemia by potentiating glucose disposal, without, in principle, affecting insulin levels. Furthermore, the consumption of a (non-simple-sugar) diet rich in a combination of high-fiber-carbohydrates (grains, legumes, and so on), proteins, and unsaturated fats may also help manage the case of hyperglycemia and help improve insulin sensitivity.

Any such supplementation program should, without exception, be supervised by a qualified medical practitioner.

I apparently did not succeed in keeping my response short! :frustrate

Originally Posted by strategicmove

Originally Posted by strategicmove

October 4, 2008 - October 7, 2008
Days 1 - 4

Originally Posted by USPLabs

DominATP Write-Up

Following the extremely successful debut of our stimulant pre-workout product, Jack3d, we received many requests from loyal USPlabs and potential customers requesting a solid and effective non-stim pre-workout formula with proven ingredients that could be stacked with Jack3d or any other stimulant containing pre-workout formula, that could be used solo during post-afternoon training sessions, or that could even be used on resting days. In effect, you asked for a potent non-stim pre-workout blend that combines not just proven ingredients at effective doses, but that is also affordable. We went to work and are proud to present you with our response: DominATP! Composed of carefully selected proven ATP synergists, anabolic and anti-catabolic cofactors, as well as hormone-modulating agents and recovery enhancers, at effective doses, DominATP is like nothing you have experienced before.
You will feel the impact hit you after the very first dose. From that point onwards, your dominant mode will be turned on, and you will demand nothing less than crushing your workout. And with the synergistic post-exercise recovery agents included, DominATP makes you look forward to your next workout! Every time! Your personal experience is your best feedback!

DominATP delivers:

• Powerful triggering and modulation of protein synthesis and reduction of muscle degradation via proven synergistic anabolic and anti-catabolic agents
• Significant boost in phosphocreatine synthesis, ATP regeneration, and VO2 max, for heightened strength and endurance
• Dramatic improvements in muscular integrity, muscle contractions, and muscular capacity
• Radical preferential stimulation of fast-twitch muscle fibers for explosiveness and power
• Boost in mitochondrial respiration, oxygen utilization, aerobic and anaerobic capacity
• Dramatically postponed onset of muscle fatigue and muscle failure
• Enhanced secretion of growth hormone, luteinizing hormone, and follicle-stimulating hormone
• Improved insulin response
• Elevated endothelial nitric-oxide synthesis, vasodilation, and muscle fullness
• Powerful antioxidant, anti-inflammatory, immune, and anti-aging support

The ingredients:

DiCreatine Malate Creatine (methyl guanidine-acetic acid, or
N-(Aminoiminomethyl)--N-methylglycine) is a naturally occurring metabolite found in red muscle tissue. Creatine can be obtained from endogenous synthesis, from diet, and from supplementation. Endogenously, creatine is metabolized in the liver from the amino acids glycine, arginine, and methionine. It is then released into the blood stream to be absorbed into muscle cells. It can also be produced in small amounts by the kidney and pancreas, in exceptional cases. As the body is unable to synthesize adequate amounts of creatine and creatine phosphate
(phosphocreatine) during times of high-intensity exertion, creatine supplementation becomes crucial. It has a substantially well established status as a strength and endurance booster (via its role in adenosine triphosphate (ATP) synthesis), a cellular hydrating agent (or cell volumizer), an important lactic acid buffer, a body mass enhancer, as well as a post-exercise recovery agent. As it turns out, some users of standard creatine monohydrate experience bloats and gastro-intestinal problems. Bonding creatine to malic acid appears to solve these problems, while providing users with the accustomed benefits of creatine supplementation. In particular, DiCreatine Malate is a molecular bonding of creatine to malate, the salt form of malic acid, in an approximately
2:1 ratio that effectively supplies the body with adequate amounts of creatine, creatine phosphate and ATP.

Traditionally, malate has been molecularly bonded to minerals, amino acids, and vitamins to improve their stability, their absorbability, as well as their bioactivity. The same principle was realized in dicreatine malate, making this advanced creatine form more PH-stable, more soluble, and significantly more bioavalable than standard creatine monohydrate.
Furthermore, as a Krebs Cycle intermediate, malate not only acts as an effective carrier for creatine, but also directly supports the production of ATP, leading to improved VO2 max and energy metabolism in skeletal muscle cells and heart myocytes. Consequently, dicreatine malate offers a unique and synergistic fusion of ATP-promoting agents, creating a powerful compound for enhancing endurance, strength, and recovery.

The malate bond is significant for another reason. Malic acid is the only Krebs Cycle metabolite that is depleted during times of physical exertion, and is one of the first steps toward physical exhaustion. As a consequence, replenishing malic acid levels via dicreatine malate supplementation plays an incredibly significant role in ATP resynthesis and energy production. As we will see later, malic acid is also involved in important detoxification processes in the body, thereby ensuring more intense workouts, delayed fatigue and muscle failure, and optimal recovery.


Beta-Alanine
This compound needs little introduction. As is well known, Beta-Alanine (the only naturally occurring ß-amino acid) and L-Histidine form the bedrock for the synthesis of the compound L-Carnosine, a very powerful pluripotent dipeptide intricately involved in a variety of deep metabolic processes. Upon consumption or supplementation in sufficient quantities, carnosine is metabolized by the enzyme carnosinase into its precursor amino acids, beta alanine and l-histidine. After absorption into skeletal muscle cells, another enzyme, carnosine synthase resynthesizes carnosine into its constituents, beta alanine and l-histidine.

Why is this of any significance to athletes? First, so-called long-lived cells, for example, nerve cells (neurons) and muscle cells (myocytes) are known to contain high concentrations of carnosine, with the level of carnosine positively correlating with the capacity for high-intensity exercise performance as well as the maximum life spans of animal species. Now, let us take a quick look at muscle fibers. There are two broad types of muscle fibers in humans, Type I
(slow-twitch) with a limited growth capacity, and Type II (fast-twitch) with a high potential capacity for growth. Type I muscle fibers appear to be more prevalent. Although carnosine is also found in Type I muscle fibers, it is preferentially located in Type II muscle fibers responsible for explosiveness and power. This means that by deliberately increasing our cellular carnosine concentrations via supplementation, we can preferentially induce higher carnosine loads in Type II muscle fibers, thus stimulating their growth and our overall muscular capacity.

Furthermore, as is well known, high intensity exercise induces a rise in intracellular H+ (hydrogen ions) and lactic acid levels, signalling the onset of fatigue, muscle failure, and reduced performance. In this connection, carnosine not only acts as a powerful antioxidant in skeletal muscle cells, but also functions as a key pH buffer, inducing the neutralization of lactic acid, and protecting skeletal muscle cell membranes from oxidation within the acidic conditions of muscular exertion. These translate into delayed fatigue and enhanced performance, as well as improved muscular integrity and contractions (due to the activation of myofibrillar-ATPase enzymes responsible for muscle contractions), with carnosine supplementation. Relatedly, carnosine also supports more efficient heart-muscle contractions via the improvement of calcium response (high acidic levels reduce ATP efficiency and obstructs calcium release) in heart myocytes, leading to improved endurance.
...

Originally Posted by strategicmove

DominATP + FREE Refresh (500 grams) By: USPowders

If you have used DominATP, we would very much appreciate your feedback in this thread. What was your experience with the product? Did you use it stand-alone? Stacked with Refresh? Stacked with Refresh and Jack3d? Stacked with Jack3d? Stacked with ...?

Thanks a lot in advance for your support. :)

Originally Posted by strategicmove

This is not a trivial question. Before I attempt an answer, I would like to insist that any individual with a known case of Type-2 diabetes should take any supplements only in consultation with a qualified medical personnel. In what follows, I will desist from making a recommendation. Rather, I will try to clarify why I think the response to your question is non-trivial, especially in the interest of those not conversant with Type-2 diabetes. I will aim to keep my response short.

There are two types of diabetic conditions, Type 1 and Type 2. Type 1 is generally regarded as an autoimmune disease. In an autoimmune disease, due to a dysfunction in the signalling network, the body attacks its own cells and organs, regarding them erroneously as foreign bodies. In the case of Type 1 diabetes, the body attacks the beta cells responsible for the manufacture of insulin. Consequently, Type-1 diabetics are unable to manufacture insulin and would need insulin replacements throughout their life time.

Type-2 diabetes, on the other hand, arises when the body is unable to utilize insulin effectively over time, leading to a condition known as insulin resistance. Here, the problem is not an inability of the body to manufacture insulin. Quite the contrary. In the beginning stages, the Type-2 diabetic experiences both hyperglycemia and hyperinsulinemia, as blood levels of insulin and glucose remain high, due to the body's inability to utilize insulin effectively. Why is this the case? In the early stages, insulin receptors show resistance to insulin, and because insulin is secreted by the pancreas to transport glucose into muscle and liver cells to be stored as glycogen, and into adipose tissue to be stored as fat reserves, glucose disposal is hindered due to this insulin insensitivity. This causes blood glucose levels to rise. The rise in blood glucose levels serves as a signal for the pancreas to secrete even more insulin to help dispose the rising blood glucose levels. This massive insulin surge can dispose some glucose, but leads to a significant increase in insulin concentration in the blood (hyperinsulinemia) in the presence of high blood glucose (hyperglycemia). This cycle of pancreatic secretion of insulin and insulin-receptor insensitivity in the presence of high glucose levels continues until the mature stage of the disease is reached, where the pancreas more or less self-destructs, producing very little insulin. This dramatically reduced levels of insulin means that glucose disposal cannot take place in any meaningful sense, leading to elevated levels of blood glucose in the presence of minute amounts of insulin. In other words, in this mature stage, hyperglycemia remains, while hypoinsulinemia sets in.

The qualitative differences between the early and subsequent stages of Type-2 diabetes means that the treatment options must be tailored accordingly.

Having summarized those key differences, it may now be said that because of elevated insulin and glucose levels in the early stages of Type-2 diabetes, compounds (such as corosolic acid in Anabolic Pump and P-Slin) that are known to trigger massive glucose disposal, independent of insulin, via stimulation of the glucose-transport protein, GLUT-4, are likely to be of immense benefit. This is because such compounds would force-drive the circulating glucose into muscle cells, ultimately reducing or reversing the condition of hyperglycemia. Once this is achieved, insulin receptors may begin to regain their sensitivity to insulin, ultimately leading to less secretion of insulin by the pancreas. This may, at the very least, stop the aggravation of the hyperinsulinemic condition, even leading to its reversal. So, Anabolic Pump and P-Slin may have their application in the early stages of Type-2, under the supervision of a qualified medical personnel.

How about during the subsequent stages characterized by hypoinsulinemia and hyperglycemia? Anabolic Pump and P-Slin can still find application here. Since they work independently of insulin, they can address the hyperglycemia by potentiating glucose disposal, without, in principle, affecting insulin levels. Furthermore, the consumption of a (non-simple-sugar) diet rich in a combination of high-fiber-carbohydrates (grains, legumes, and so on), proteins, and unsaturated fats may also help manage the case of hyperglycemia and help improve insulin sensitivity.

Any such supplementation program should, without exception, be supervised by a qualified medical practitioner.

I apparently did not succeed in keeping my response short! :frustrate

Originally Posted by USPLabs

What is focus Dirt?

An adrenal adatagenic/nootrophic....Basically increases Concentration while aiding in adrenal recovery...

Who wants it to be a NP exclusive?
Me!

Is iT Special?

Been holding out this special powder for a future product but to much on my plate. In USPlabs style it's an Engineered Extract that the supplement industry has never seen.

Cost?

Hmmm about 25 for a 30-40 day supply...


Is there demand?

If so please Bump this thread.

Originally Posted by strategicmove

As you know, the pathways and actions of neurotransmitters, whether they are tyrosine-derived, serotonin-derived, or not, are significantly more complex than a mutual bidirectional dopamine-serotonin antagonism. In terms of PowerFULL or dopamine, if you get the “GH side of it”, as you put it, then you get the entire picture! PowerFULL elicits elevated growth-hormone production via a dopaminergic pathway. As you know, several classes of agents stimulate or inhibit growth-hormone secretion. In particular, the hypothalamic action of dopamine leads to an inhibition of somatostatin, allowing Growth hormone-releasing hormone (GHRH) to induce growth hormone secretions (more later). Furthermore, amines, whether catecholamines (for example, dopamine) or indolamines (for example, serotonin), can promote growth hormone secretion via alpha adrenergic stimulation (for catecholamines), beta-adrenergic inhibition (for catecholamines), dopaminergic stimulation (for catecholamines), or serotoninergic stimulation (for indolamines). The reverse cases (beta-adrenergic stimulation, alpha-adrenergic inhibition, dopamine inhibition, and serotonin inhibition) may lead to inhibition of growth-hormone release. Other factors that may stimulate growth-hormone secretion may include amino acids, the condition of hypoglycaemia, exercise, sleep, certain hormones, and so on. Of course, all these agents do not produce an equal boost in growth hormone. Dopamine, for instance, is known to be a potent growth-hormone agonist. PowerFULL uses this mechanism. Taken pre-bed, the potent GH-stimulating effects ensure a deep, restful sleep, and promotes superior repair of cellular damage. Taken pre-workout in a fasted state, growth-hormone release is equally induced, and acts in concert with the growth-hormone produced by exercise. This PowerFULL-induced growth-hormone surge pre-workout may produce lethargy in some users, requiring the simultaneous supplementation with a smooth-acting stimulant to ensure high motivation, concentration, and a laser-like focus during workout. So, PowerFULL, via its dopaminergic action, in this case, is extremely useful pre-workout and pre-bed.

I would like to add a few more comments to this, in order to address some of your other concerns. As you correctly implied, dopamine is derived from the synthesis of tyrosine. Put differently, dopamine is a tyrosine-derived neurotransmitter. As you also know, tyrosine can be incorporated into proteins, can be broken down for energy production, or can be converted into catecholamines. These catecholamines are neurotransmitters such as dopamine, norepinephrine, and epinephrine. The conversion of tyrosine into catecholamines is made possible by the action of the enzyme, tyrosine hydroxylase. The ensuing reaction produces DOPA (3,4-dihydrophenylalanine). Via the enzymatic action of DOPA decarboxylase, DOPA is converted to dopamine, which is, in turn, converted by dopamine ß-hydroxylase into norepinephrine. Finally, norepinephrine is converted by phenyletanolamine N-methyltransferase into epinephrine. However, the full conversion from tyrosine to epinephrine is only realized in the adrenals. In the brain, the conversion ends at dopamine! Furthermore, catecholamines can exhibit excitatory and inhibitory effects, which is why they can support higher metabolic activity and rest. Dopamine can act as an inhibitory and as an excitatory neurotransmitter. The dopamine receptors determine which pathway to utilize.
Dopamine has been shown severally to support growth hormone secretion via somatostatin secretion. As somatostatin blunts growth hormone secretion, the dopamine inhibition of somatostatin enhances the action of the dipeptide, Growth hormone-releasing hormone (GHRH). This leads to an elevated release of growth hormones.

On its own, serotonin (5-hydroxytryptamine) is a tryptophan-derived neurotransmitter. Although it is a monoamine neurotransmitter like dopamine, it is regarded as an indolamine, and not as a catecholamine (like dopamine). Serotonin is derived from tryptophan via a hydolation reaction (tryptophan hydroxylase) and a decarboxylation reaction (amino acid decarboxylase). Consequently, melatonin (N-acetyl-5-methoxytryptamine) is derived from serotonin in the pineal gland via the actions of the enzymes, serotonin-N-acetyltransferase and hydroxyindole-o-methyltransferase, both of which are most active in the dark. Furthermore, serotonin is primarily found in the gastrointestinal tract. Only small amounts are found in the brain. As tyrosine and tryptophan (as well as methionine, the branched-chain amino acids, and so on) depend on a neutral protein transporter to reach the brain for synthesis, a large amount of one of these can crowd-out the others, favouring its synthesis in the brain.

To summarize, dopamine is a powerful stimulus for growth-hormone secretion, via a series of steps. PowerFULL's impact on growth-hormone secretion is dopaminergic. Taken in a fasted state, PowerFULL can induce a significant increase in dopamine, and consequently, growth-hormone, whether pre-workout, or pre-bed.

Originally Posted by strategicmove

I am thoroughly excited to formally apply for the position of a Product Educator at USPLabs. USPLabs' commitment to developing exceptional products based on deep innovation has always attracted my attention and respect. It will be a major honour to be associated with the company in any position, especially as a Product Educator.

Considering that there is no formally requested structure for the application, I'll take the liberty to say a few things about myself.

I currently work as Head of Controlling/Financial and Strategic Risk Management for a software company headquartered in Bavaria, Germany, but with global operations. Before then, I had worked in several continents as Financial Analysis Manager for Procter & Gamble, the consumer goods company, with several assignments in consumer and customer teams. During this sojourn, I was able to hone my broad skills as a businessman with financial expertise. In particular, the requirements of those positions stimulated and encouraged team members to sharpen their communications, inter-personal, as well as customer-and-consumer relationship skills.

In terms of my educational background, I have an M.Sc. and a Ph.D in Economics. While this background has no direct relationship with nutritional science and biochemistry, I took deep interest in several disciplines a few years ago. These range from classical philosophy, history of arts, broad strokes in the development of the mathematical sciences roughly from Euclid through Leibniz/Newton to the golden years of the early 20th century and their implications on progress in theoretical and applied physics, and so on. One other area that caught (and trapped) my attention was (is) the general behaviour and relationships between molecular and biological phenomena. This led me to biochemistry, as well as the medical and nutritional sciences. Building on pre-university chemistry classes, I have tried over the years to sharpen my understanding of the theoretical and practical aspects of these sciences, especially in terms of the pharmacological effects of herbal and synthetic compounds. I try to share this understanding, in as simple terms as possible, with other "travellers" in the journey to a better understanding of our supplements and their possible biological impact on our athletic goals and well-being.

I would like to believe that a combination of my modest understanding of nutritional science, my deep commitment and dedication to sharing knowledge, as well as my experience in inter-personal and consumer dynamics should appropriately prepare me for the position of a Product Educator at USPLabs.

I would not be interested in affiliation with any company that would neither appreciate my contribution nor offer me a chance to grow within the company. With this background, I truly consider this opportunity at USPLabs as ideal, as it would permit me to use my hobby as a basis for helping drive USPLabs' business forward, and growing with the company in the process.

I look forward to discussing further details of this position with you, should you decide to offer me the unique position.

I hope your company will continue to break new grounds in supplementation, in line with the tradition it has established.

Thank you very much for taking your time to review this application.

Originally Posted by strategicmove

Nice to have you around again, bud! Wish you a fast recovery! :thumbsup:

Originally Posted by Steveoph

The demand is always there. The Tribulosin is the sugar on top of the PureSap from this poll http://anabolicminds.com/forum/nutra...p-request.html . Prime has shown itself capable of producing the Alpha Male feeling in some guys, I can't wait to see how effective a product designed primarily with that in mind will perform.

Will this be a bulk powder release?

Originally Posted by B5150

Originally Posted by Mulletsoldier

The following was a study conducted at Indigo Biosciences, by Penn State University researchers, written by BA Sherf, Ph.D and approved by J. Vanden Heuvel, Ph.D to validate one of the major claims [and benefits] surrounding PRIME?s efficacy: A lack of suppressive hormonal action. While "hormonal suppression" is almost exclusively represented as sex-steroidal, suppressive can refer to other endocrine functions such as GR [glucocorticoid receptor] antagonism. GR expression is ubiquitous: Appearing in almost every cell-type in the human body, the agonism and antagonism [and resultant effects on gene regulation] of the GR has a wide array of physiological consequences; ranging from sex-function to the immune system. As a result, this particular endeavor was undertaken to determine whether or not GR antagonism was occurring, and to what degree, to ensure that no hormonal action was occurring.

Fortunately for the consumer, this Penn State Study is the first step in a thorough legitimization process that USPlabs is embarking on with PRIME; it (the Penn State study) will be accompanied by an objective trial of sorts (The Staley Report), where trainees were selected away from mainstream boards (and the associated biases ? positive or negative) and thoroughly recorded their progress under Charles Staley; it will also be accompanied by the release of the Beta Tester's blood abstracts which, along with this particular study, will display no cyto-toxicity and no suppression of endogenous hormones.

Simply, we are objectively validating what we know to be subjectively successful, through unaffiliated, and independent means. While detractors will no doubt detract - merely on a new tangent - upon seeing this study, we feel it important to communicate the uniqueness of the actions we are currently undertaking. The expense and bureaucracy involved in securing studies such as this one from respectable and recognized Universities is enormous; and this is exactly why we [as an industry and consumer] seldom see them surface. While University studies such as this one are often utilized as objective research, they are very seldom conducted for the company itself; however, in the case of PRIME, realizing a lack of objective data to validate consumer feedback, we thought it was only necessary. Fortunately for the consumer, that process has only begun, and not ended, here: The results in respects to GR Antagonism came back negative, as we had hoped;however, as a company we are diligent in our desire to positively illuminate the exact MoA [method of action] of USPlabs PRIME.

However, in that light, we must remember that many products we commonly use today do not have validated MOAs; much in the fashion we have done here, simply their safety and efficacy need be validated for them to be produced en masse. For example, Minoxidil (Rogaine), one of the most effective and the widest-selling hair treatment products available, does not have a proven MOA. Much like PRIME, there are several postulates (one being the mediation of the NO pathway, despite the fact no cGMP-specific action has been proven) but none proven. Does this in any way invalidate the massive body of anecdotal feedback surrounding Minoxidil? Of course not: Despite the lack of MOA for Minoxidil, it is still regarded as the ?first-line-of-defense? for uncomplicated hair loss.

Even Acetaminophen - a compound so engrained in popular culture and medicine, your spell-checker recognizes it - has no verified specific MoA. While it has been elucidated that Acetaminophen lowers levels of Prostaglandin E2, the exact mechanism [Mechanism of Action] through which this is accomplished has not been elucidated. As PGE is a product of the commonly inhibited COX [cyclo-oxygenase, in forms I and II] pathway, Acetaminophen?s exact effect on COX [if any is occurring] is unknown and debatable. This point, then, cannot be stressed enough in regards to the actions USPlabs is currently undertaking: We are seeking to provide for PRIME what has not been provided for the widest-selling analgesic available. Why USPlabs is being subjected to a standard not subjected to a compound each person reading this has ingested remains a mystery ? this being said, we do intend to live up to even the most veracious of detractors in regards to our attempts to validate and legitimize PRIME.

In conclusion, we realize two things: a) that PRIME is a contemptuous topic as of late and; b) that this product, as efficacious as it may be, needs some external validation to dissuade some of the negativity surrounding it. We are going through these great lengths ? funding University Studies, in-depth trials and blood tests and expending massive amounts of capital and energy to do so? to address both of these things at the same time. Simply put, a ?scam company? would not do anything of this scope or magnitude for an ineffective product; we know PRIME works, we simply want to know how, and want YOU to know how....

Originally Posted by strategicmove

SuperSaponins is not just PureSap, but also includes the powerful Tribulus Extract, Tribulosin. This is why a direct comparison of SuperSaponins plus 1-carboxy versus PowerFULL may be skewed.

Steveoph's layout is fine. Start SuperSaponins at 2 x 2g daily. If you wish to take some break during the week, use 3 x 2g for five consecutive days and take the next two days off. Then repeat.
As for 1-Carboxy, 1 x 2g + 1 x 1g is fine.

Originally Posted by strategicmove

A good dosing approach would be to take 1.5mg pre-workout and 500mg - 700mg pre-bed. Both on an empty stomach. After 7 - 10days, take 2gr pre-workout and 1gr - 1.5gr pre-bed.

Originally Posted by strategicmove

Original version of PRIME: 600mg of ingredients per capsule. Count size (NutraPlanet) = 120 capsules
New version of PRIME: 800mg of ingredients per capsule. Count size (NutraPlanet) = 120 capsules. The GNC version will be 800mg per capsule (as in the NutraPlanet version), but 150 capsules per bottle. GNC will also be more expensive than NutraPlanet.

In any case, comparing the original version and the new (120 capsule) version, six (6) capsules (= 6 capsules x 800mg per capsule = 4,800mg of ingredients) of the new version will be equivalent to eight (8) capsules (= 8 capsules x 600mg per capsule = 4,800mg of ingredients) of the original. At the same price as the original! Basically, you are getting 33% more value! Unprecedented!

Originally Posted by strategicmove

This thread might help:
http://anabolicminds.com/forum/usp-l...endations.html




Clearly, these are benefits that are desirable both on workout and non-workout days.

Furthermore:

Originally Posted by strategicmove

Like Borobulker suggested, Refresh is a versatile matrix. Depending on desired objective, it can be taken first thing in the morning, or pre-workout along with a pre-workout formula such as Jack3d, or even in the evening. If you desire to use Refresh to boost adaptogenic and adrenal capacity, while augmenting focus, concentration, cognitive and memory benefits on a given day, outside of a gym environment, it might be useful to dose it early in the day. For enjoying the same benefits during workout, Refresh can be taken pre-workout. For post-workout recovery support, Refresh may be supplemented in the evening of a workout day.

Originally Posted by USPLabs

First 100 orders get this Awesome product that I use when I stop using Jacked and stacked with Sloppy seconds it is such a smooth mental rides...A great change a pace!

Schzandrin 15% 500mgs
Gynostemma 98% gypenosides 300mgs
Bacopa (40% bacosides)200mgs
Tribulus Terristris(extracted for tribulosin) 1250mgs

3 cap serving size

Originally Posted by USPLabs

on the way fellas...DominATP AKA sloppy Seconds

30 day servings of a beefed up blend of

3 scoops(yes this New age bulk company gives you a scoop)
Dicreatine malate 4500mgs
Beta Alanine 3000mgs
Leucine 5000mgs
Citrulline Malate 3500mgs
Agmatine Sulfate 500mgs

In a delicious LEMON TART flavor---hmmmmm

Originally Posted by USPLabs

A natural selective NONHORMONAL inhibitor of the enzyme 11-B-hydroxysteroid dehydrogenase type 1.

50% coffee extract which is the equivalent to drinking about 100 expressos without the caffiene.


Who can name the hormonal inhibitior of the same enzyme?

Originally Posted by borobulker

The Six Pack Stack Sack: What it is

A dynamic and open dialogue used to facilitate the growing number of Six Pack Stack-specific questions. All of the representatives, including myself, will consistently update this thread with any new suggestions or strategies to best maximize these two products! Alternatively, we will also pay keen attention to this particular thread, as we did with our Quick Questions Thread.

Essentially, this is an FAQ tool, of sorts; a more evolving and dynamic way to ensure products are properly maximized, rather than a stiff, rigid, and unchanging user guide. While the basics featured on product pamphlets and websites will be found here, they will not be presented in a cut-and-paste type format; they will be altered and expounded upon specific to each consumer's unique needs.

Further, it will exist as a real-time guide for individual's wishing to track their progress, and express their feelings on this specific stack of USPlabs progress. Almost like a mini community within a community.

Please, make this a valuable and oft-utilized tool for the entire board!

Originally Posted by strategicmove

This is not a typical "supplement" article, but it is nonetheless an interesting read. This article is from the latest print edition of the authoritative newspaper, The Economist. For some, The Economist may not be an obvious address for such an article, but the newspaper has international recognition for its authoritative, objective, and in-depth reserach. If you have the time to read the entire article, you might find one insight or the other. Be warned: The article is long! The advantage, though, is that it is written in simple, non-technical language. Enjoyable! :thumbsup:

Abolishing Ageing
How to live forever

Jan 3rd 2008

From The Economist print edition

It looks unlikely that medical science will abolish the process of ageing. But it no longer looks impossible
“IN THE long run,” as John Maynard Keynes observed, “we are all dead.” True. But can the short run be elongated in a way that makes the long run longer? And if so, how, and at what cost? People have dreamt of immortality since time immemorial. They have sought it since the first alchemist put an elixir of life on the same shopping list as a way to turn lead into gold. They have written about it in fiction, from Rider Haggard's “She” to Frank Herbert's “Dune”. And now, with the growth of biological knowledge that has marked the past few decades, a few researchers believe it might be within reach.
To think about the question, it is important to understand why organisms—people included—age in the first place. People are like machines: they wear out. That much is obvious. However a machine can always be repaired. A good mechanic with a stock of spare parts can keep it going indefinitely. Eventually, no part of the original may remain, but it still carries on, like Lincoln's famous axe that had had three new handles and two new blades.

The question, of course, is whether the machine is worth repairing. It is here that people and nature disagree. Or, to put it slightly differently, two bits of nature disagree with each other. From the individual's point of view, survival is an imperative. You cannot reproduce unless you are alive. A fear of death is a sensible evolved response and, since ageing is a sure way of dying, it is no surprise that people want to stop it in its tracks. Moreover, even the appearance of ageing can be harmful. It reduces the range of potential sexual partners who find you attractive—since it is a sign that you are not going to be around all that long to help bring up baby—and thus, again, curbs your reproduction.

The paradox is that the individual's evolved desire not to age is opposed by another evolutionary force: the disposable soma. The soma (the ancient Greek word for body) is all of a body's cells apart from the sex cells. The soma's role is to get those sex cells, and thus the organism's genes, into the next generation. If the soma is a chicken, then it really is just an egg's way of making another egg. And if evolutionary logic requires the soma to age and die in order for this to happen, so be it. Which is a pity, for evolutionary logic does, indeed, seem to require that.

The argument is this. All organisms are going to die of something eventually. That something may be an accident, a fight, a disease or an encounter with a hungry predator. There is thus a premium on reproducing early rather than conserving resources for a future that may never come. The reason why repairs are not perfect is that they are costly and resources invested in them might be used for reproduction instead. Often, therefore, the body's mechanics prefer lash-ups to complete rebuilds—or simply do not bother with the job at all. And if that is so, the place to start looking for longer life is in the repair shop.

Seven deadly things
One man who has done just that is Aubrey de Grey. Dr de Grey, who is an independent researcher working in Cambridge, England, is a man who provokes strong opinions. He is undoubtedly a visionary, but many biologists think that his visions are not so much insights as mischievous mirages, for he believes that anti-ageing technology could come about in a future that many now alive might live to see.
Vision or mirage, Dr de Grey has defined the problem precisely. Unlike most workers in the field, he has an engineering background, and is thus ideally placed to look into the biological repair shop. As he sees things, ageing has seven components; deal with all seven, and you stop the process in its tracks. He refers to this approach as strategies for engineered negligible senescence (SENS).

The seven sisters that Dr de Grey wishes to slaughter with SENS are cell loss, apoptosis-resistance (the tendency of cells to refuse to die when they are supposed to), gene mutations in the cell nucleus, gene mutations in the mitochondria (the cell's power-packs), the accumulation of junk inside cells, the accumulation of junk outside cells and the accumulation of inappropriate chemical links in the material that supports cells.
It is quite a shopping list. But it does, at least, break the problem into manageable parts. It also suggests that multiple approaches to the question may be needed. Broadly, these are of two sorts: to manage the process of wear and tear to slow it down and mask its consequences, or to accept its inevitability and bring the body in for servicing at regular intervals to replace the worn-out parts.

Eat up your greens
Managing wear and tear may not be as complicated as it looks, for the last five items on Dr de Grey's list seem to be linked by a single word: oxidation. Regular visitors to the “health and beauty” sections of high-street pharmacies will, no doubt, have come across creams, pills and potions bearing the word antioxidant on their labels and hinting—though never, of course, explicitly saying—that they might possibly have rejuvenating effects. These products are the bastard children of a respectable idea about one of the chief causes of ageing: that one big source of bodily wear and tear, at least at the chemical level, is the activity of the mitochondria.
Mitochondria are the places where sugar is broken down and reacted with oxygen to release the energy needed to power a cell. In a warm-blooded creature such as man, a lot of oxygen is involved in this process, and some of it goes absent without leave. Instead of reacting with carbon from the sugar to form carbon dioxide, it forms highly reactive molecules called free radicals. These go around oxidising—and thus damaging—other molecules, such as DNA and proteins, which causes all sorts of trouble. Clear up free radicals and their kin, and you will slow down the process of ageing. And the chemicals you use to do that are antioxidants.

This idea goes back to one of the founders of scientific gerontology, Bruce Ames of the University of California, Berkeley. Dr Ames began his career studying cancer. He found that damage to certain genes was a cause of cancer. These genes evolved to keep tumours at bay by stopping cells dividing too readily, and the damage was often done by oxidation. Gradually, his focus shifted to the more general damage that oxidation can do—and what might, in turn, be done about it.

Some vitamins, such as vitamin C, are antioxidants in their own right. This is the basis of the high-street propaganda, though there is no evidence that consuming such antioxidants in large quantities brings any benefit. A few years ago, however, Dr Ames found he could pep up the activity of the mitochondria of elderly rats—with positive effects on the animals' memories and general vigour—by feeding them two other molecules: acetyl carnitine and lipoic acid. These help a mitochondrial enzyme called carnitine acetyltransferase to do its job. Boosting their levels seems to compensate for oxidative damage to this enzyme. He also reviewed the work of other people and found about 50 genetic diseases caused by the failure of one enzyme or another to link up with an appropriate helper molecule. Such helpers are often B vitamins, and the diseases were often treatable with large doses of the appropriate vitamin.

The enzyme damage in these diseases is similar to that induced by oxidation, so Dr Ames suspects that its effects, too, can be ameliorated by high doses of vitamins. He has gathered evidence from mice to support this idea, but whether it is the case in people has yet to be tested. Nor is it easy to believe it ever will be. The necessary clinical trials would be long-winded. They would also be expensive—and there is no reason for vitamin companies to pay for them since sales are already buoyant and the products could not be patented. Nor is Dr Ames claiming vitamins will make you live longer than a natural human lifespan, even if he thinks they might prolong many individual lives. For that, other technologies will need to be invoked.


Abolishing ageing | How to live forever | Economist.com

Originally Posted by strategicmove

Here are two articles that may be of interest to some of you. For me, it bothers on magic that cocoa polyphenols are capable of providing such profound health benefits. Enjoy!

Both articles are from the Life Extension Foundation.

Originally Posted by USPLabs

69 protocol is hitting the Internet scene in a big way.

workout days
3 morning dose with food
2 with another meal
2 35-45 minutes pre workout (amazing stacked with Jack3d, powerfull)
2 with last meal of the day

off days
2 with food 3 times a day

I take one day off a week.

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