Originally Posted by strategicmove

This is not a trivial question. Before I attempt an answer, I would like to insist that any individual with a known case of Type-2 diabetes should take any supplements only in consultation with a qualified medical personnel. In what follows, I will desist from making a recommendation. Rather, I will try to clarify why I think the response to your question is non-trivial, especially in the interest of those not conversant with Type-2 diabetes. I will aim to keep my response short.

There are two types of diabetic conditions, Type 1 and Type 2. Type 1 is generally regarded as an autoimmune disease. In an autoimmune disease, due to a dysfunction in the signalling network, the body attacks its own cells and organs, regarding them erroneously as foreign bodies. In the case of Type 1 diabetes, the body attacks the beta cells responsible for the manufacture of insulin. Consequently, Type-1 diabetics are unable to manufacture insulin and would need insulin replacements throughout their life time.

Type-2 diabetes, on the other hand, arises when the body is unable to utilize insulin effectively over time, leading to a condition known as insulin resistance. Here, the problem is not an inability of the body to manufacture insulin. Quite the contrary. In the beginning stages, the Type-2 diabetic experiences both hyperglycemia and hyperinsulinemia, as blood levels of insulin and glucose remain high, due to the body's inability to utilize insulin effectively. Why is this the case? In the early stages, insulin receptors show resistance to insulin, and because insulin is secreted by the pancreas to transport glucose into muscle and liver cells to be stored as glycogen, and into adipose tissue to be stored as fat reserves, glucose disposal is hindered due to this insulin insensitivity. This causes blood glucose levels to rise. The rise in blood glucose levels serves as a signal for the pancreas to secrete even more insulin to help dispose the rising blood glucose levels. This massive insulin surge can dispose some glucose, but leads to a significant increase in insulin concentration in the blood (hyperinsulinemia) in the presence of high blood glucose (hyperglycemia). This cycle of pancreatic secretion of insulin and insulin-receptor insensitivity in the presence of high glucose levels continues until the mature stage of the disease is reached, where the pancreas more or less self-destructs, producing very little insulin. This dramatically reduced levels of insulin means that glucose disposal cannot take place in any meaningful sense, leading to elevated levels of blood glucose in the presence of minute amounts of insulin. In other words, in this mature stage, hyperglycemia remains, while hypoinsulinemia sets in.

The qualitative differences between the early and subsequent stages of Type-2 diabetes means that the treatment options must be tailored accordingly.

Having summarized those key differences, it may now be said that because of elevated insulin and glucose levels in the early stages of Type-2 diabetes, compounds (such as corosolic acid in Anabolic Pump and P-Slin) that are known to trigger massive glucose disposal, independent of insulin, via stimulation of the glucose-transport protein, GLUT-4, are likely to be of immense benefit. This is because such compounds would force-drive the circulating glucose into muscle cells, ultimately reducing or reversing the condition of hyperglycemia. Once this is achieved, insulin receptors may begin to regain their sensitivity to insulin, ultimately leading to less secretion of insulin by the pancreas. This may, at the very least, stop the aggravation of the hyperinsulinemic condition, even leading to its reversal. So, Anabolic Pump and P-Slin may have their application in the early stages of Type-2, under the supervision of a qualified medical personnel.

How about during the subsequent stages characterized by hypoinsulinemia and hyperglycemia? Anabolic Pump and P-Slin can still find application here. Since they work independently of insulin, they can address the hyperglycemia by potentiating glucose disposal, without, in principle, affecting insulin levels. Furthermore, the consumption of a (non-simple-sugar) diet rich in a combination of high-fiber-carbohydrates (grains, legumes, and so on), proteins, and unsaturated fats may also help manage the case of hyperglycemia and help improve insulin sensitivity.

Any such supplementation program should, without exception, be supervised by a qualified medical practitioner.

I apparently did not succeed in keeping my response short!