LETRONE FAQ!!!

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  1. LETRONE FAQ!!!


    Black Lion Research is proud to announce the release of Letrone.
    This product is a natural anabolic aromatase inhibitor.

    Atractylodes Macrocephala-
    Atractylodes macrocephala Koidz (A. macrocephala), a Chinese medicinal herb, has been extensively used to treat digestive diseases in China and most other Asian countries (PPRC, 2005; Lee et al, 2007). Dry rhizomes of A. macrocephala are rich in sesquiterpenes and acetylenic compounds (Endo et al, 1979; Chen 1987; Huang et al, 1992; Lin et al, 1997). Typical polysaccharides atractan A, B, and C, present in A. macrocephala, have been reported to exhibit hypoglycaemic activities (Wang et al, 2000; Jia et al, 2003). Although atractylenolide I, atractylenolide II and atractylenolide III are all bioactive substances present in Atractylodes macrocephalae, the majority of research studies carried out in the recent years have focused on atractylenolide II and atractylenolide III (Kang et al., 2011b). Atractylenolide II is a marker substance present in Atractylodes macrocephalae which exhibits well-documented gastrointestinal inhibitory effects and anticancer activity (Zhang et al., 1999; Liu et al., 2005). Atractylenolide II is one of the main constituents present in the effective volatile oil fraction (Li et al., 2001), potentially effective in treating senile dementia. Atractylenolide III is a possible candidate for the treatment of human lung carcinoma (Kang et al., 2011a).

    Aromatase inhibition
    Primary targets for aromatase inhibition are atractylenolide 1 2 and 3 with atractylenolide 1 being exceptionally strong with 94.5% inhibition.

    Abstract: Ten compounds were isolated from the dichloromethane extract of Atractylodes
    macrocephala and their aromatase inhibiting activities were tested using an in vitro
    fluorescent-based aromatase assay. The results indicated that atractylenolide I (1),
    atractylenolide II (2) and atractylenolide III (3) had inhibition ratios of 94.56 0.70%,
    90.93 1.41% and 86.31 8.46%, respectively
    , at a concentration of 10 μM. We conclude
    from our results that atractylenolide and its derivates may serve as potential aromatase
    inhibitors (AIs) and thus merit continued study in the future.

    FULLTEXT= Screening for Compounds with Aromatase Inhibiting Activities from Atractylodes macrocephala Koidz jourlib.org

    Atractylenolides are exceptionally strong aromatase inhibitors that show exceptional oral bioavailability. There are many AIs in nature. During my research I must have found over 100 potentials but unfortunately 99.9999% of them are poorly absorbed orally which limits their potential.
    Atractylenolide in contrast is very well absorbed.

    Sites-
    -"Atractylenolide I is absorbed quite well at all segments of intestine in rats and no specific absorption was founded in different segment."

    -"Atractylenolide I can be classified into high penetrating drug. Passive diffusion dominates the absorptive transport behivior of atractylenolide I. Atractylenolide I can be absorbed in the whole intestinal segments and there is not a preferntial absorption zone in the intestine. The absorption and secretion of atractylenolide I are mediated by the efflux transport system, P-gp."

    -"Abstract
    The intestinal permeability of three sesquiterpene lactones, atractylenolide I, II, and III, was investigated using the human Caco-2 cell monolayer model. The bidirectional permeability of the three compounds from the apical (AP) to the basolateral (BL) side and in the reserved direction was studied. The three compounds were assayed using HPLC. The P app values ​​of atractylenolide I, II, and III were all at the level of 10 -5 cm / s, suggesting high intestinal permeability and good absorption. The bidirectional transport of the three compounds was time- and concentration-dependent, and indicated the main mechanism of the passive diffusion of the three compounds across the intestinal epithelium membrane. Moreover, atractylenolide I might be partly actively transported. "


    ANABOLIC-
    It was a huge loss when Formestane got canned because well....Ais are great but that was also anabolic.
    Letrone is a stout AI but it also shows significant anabolic potential by increasing endogenous hormones.
    In one animal study growth was increased by 20% compared to control when animals were fed atractylodes macrocephala.
    The increase in growth was attributed to increases in-
    Growth hormone x30%
    IGF-1 x52%
    T3 x47%
    T4 x36%
    cAMP x21%

    Sites- The Endocrinal Mechanism of Polysaccharide of Atractylodes Macrocephala Koidz on Growth Performance of Weaned Piglets--
    "Comparing to the control group,the PAM group increased the average gain weight by 20.72%"
    "increased the levels of growth hormone(GH),insulin-like growth factor-I(IGF-I),3,5,3′-triiodothyronine(T3),3,5,3′,5′-tetraiodothyronine(T4) and cyclic adenosine monophosphate(cAMP) in serum by 30.77%(P0.05),52.02%(P0.05),47 .60%(P0.05),36.70%(P0.05) and 21.15%(P0.05),respectively.The results indicated that PAM improved the growth performance of weaned piglets through the endocrinal system.Furthermore,it is possible that PAM altered the growth performance of weaned piglets by up-regulating the synthesis and secretion of GH,IGF-1,T3,T4 and cAMP."


    Finally, Atractylodes macrocephala potentiates Ghrelin secretion and receptor signaling. Ghrelin increases hunger and Growth hormone secretion.

    Now you have not only an exceptionally strong oral AI but one that has serious anabolic potential.


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    BLACK LION RESEARCH Take your own path-


  2. ^^^^ if you cant pronounce the ingredients you know it has to be DAMN good seriously cant wait to run this, like I mentioned before, it seems very similar to one of my alltime FAV AI's . I will make sure to log when I get mine, and the fact it helps with digestive issues makes it sound even better.. Thanks Brundel/BLR for putting in the hours/days/months of work to bring us this.
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  3. When will it be available at the UK retailers ?

  4. Quote Originally Posted by Pride89 View Post
    When will it be available at the UK retailers ?
    I am shipping to PMS tomorrow.
    JW and PRED have made significant orders as well but PMS bit first so Im shipping to them first.
    BLACK LION RESEARCH Take your own path-

  5. Quote Originally Posted by brundel View Post
    I am shipping to PMS tomorrow. JW and PRED have made significant orders as well but PMS bit first so Im shipping to them first.
    Good stuff ! I like *********** better anyways
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  6. sick... thanks!

  7. Quote Originally Posted by Pride89 View Post
    Good stuff ! I like *********** better anyways
    they got good prices and good selection I've noticed.

  8. You're going to love it guys. I promise..! Plus no joint issues
    Serious Nutrition Solutions Rep / TGB Supplements.com Rep

    vujade5 @ TGB - Save 5% off upto $149 / vujade7 @ TGB - Save 7% over $150

  9. ^^^ that's a BIGGIE the joint b.s.

  10. Just want to point out that stock is at 50%. Sales have been triple what was expected. Get it while its hot.
    Thankfully I have more raws already here
    not gonna have THAT happen to me again.
    BLACK LION RESEARCH Take your own path-

  11. Thought this was good info for the FAQ section.

    Quote Originally Posted by vujade View Post
    LetroneUses:

    Heavy AAS/PH cycles @ 2 caps a day

    Light AAS/PH cycles @ 1 cap a day

    Post Cycle - 1 cap a day a 1 cap a day

    TRANSDERMAL AI Uses:

    Light AAS/PH cycles

    Natural Cycles w/ Viron & Follidron

    Solo during a recomp or cutting cycle

    Stacked with a fat burner like Inciderine during a recomp or cutting cycle





    It will not require a PCT.

    Yes the transdermal would be better for recomp because it has 2 fat burners in it.
    OLYMPUS UK REP
    Use JEBROOK30 for 30% off at
    http://olympusuk.com/

  12. Just wondering, what's the rice flour for in the blend? I've been assuming it's just to prevent anyone knowing and therefore ripping off the exact goldilocks quantity of the A. macrocephala in each cap, but does it have a purpose beyond that?
    Also, did people doing beta tests take this on an empty stomach or with a meal? Does it matter?
  13. Official Strong Supplement Shop Board Rep
    Visit Strong Supplements Here
    Join Us In The Pursuit of Strength - Go Strong!

  14. Really no joint drying???

    I stocked up on Formeron before it got pulled. Love it but I know almost instantly when I over do it my neck and my shoulders start to hurt.

    That would be amazing to drop E2 without joint issue. But I thought the joint issue was because E2 holds water (drying out joints etc when it drops) Is there another mechanism Letrone drops E2 without effecting joints? That would be incredible.

  15. Quote Originally Posted by conkertheking View Post
    Just wondering, what's the rice flour for in the blend? I've been assuming it's just to prevent anyone knowing and therefore ripping off the exact goldilocks quantity of the A. macrocephala in each cap, but does it have a purpose beyond that?
    Also, did people doing beta tests take this on an empty stomach or with a meal? Does it matter?
    100% just for a smokescreen.
    im sure itll get cloned anyways but its gonna be tough to copy this. I have ...ehem some tricks up my sleeve
    We didnt have anyone specifically eat it on full or empty stomach. Its very well absorbed and is used in other cases for gastric issues so I would take it on empty stomach knowing it wont cause any stomach upset.
    BLACK LION RESEARCH Take your own path-

  16. Can I log a bottle? I'm in the middle of a cut and plateauing hard with fat loss and energy/strength

  17. Quote Originally Posted by chedapalooza View Post
    Can I log a bottle? I'm in the middle of a cut and plateauing hard with fat loss and energy/strength
    Damn! sounds like it could Def, help that situation! is your intake a little low you think as far as losing your energy and strength? that's usually the reason behind it..

  18. picked up a bottle. Going to run it at 1cap/day to see the effects then switch to td for comparison
    Resident Supple Leopard and Software Engineer

  19. Quote Originally Posted by KilaCali View Post
    Damn! sounds like it could Def, help that situation! is your intake a little low you think as far as losing your energy and strength? that's usually the reason behind it..
    Yea I'm between 1400-at most 1600 daily the extra cals from protein only. Fat is 30-45 and carbs always 30 or less.. I'm 152 9%. Been at it two months. Hurtin now lol. Trying to pull out all the stops. I just bought a bottle from TGB. I'm currently on 25mg daily of arimistane and will try dropping that and adding this in when it comes.

    Can anyone suggest 1 or 2 caps dosing?? Figure just start with one?

  20. Quote Originally Posted by chedapalooza View Post
    Yea I'm between 1400-at most 1600 daily the extra cals from protein only. Fat is 30-45 and carbs always 30 or less.. I'm 152 9%. Been at it two months. Hurtin now lol. Trying to pull out all the stops. I just bought a bottle from TGB. I'm currently on 25mg daily of arimistane and will try dropping that and adding this in when it comes.

    Can anyone suggest 1 or 2 caps dosing?? Figure just start with one?
    ^^^Yep. If you're not on anything strong just start with one cap. 2 month supply that way!
    OLYMPUS UK REP
    Use JEBROOK30 for 30% off at
    http://olympusuk.com/

  21. Quote Originally Posted by chedapalooza View Post
    Yea I'm between 1400-at most 1600 daily the extra cals from protein only. Fat is 30-45 and carbs always 30 or less.. I'm 152 9%. Been at it two months. Hurtin now lol. Trying to pull out all the stops. I just bought a bottle from TGB. I'm currently on 25mg daily of arimistane and will try dropping that and adding this in when it comes.

    Can anyone suggest 1 or 2 caps dosing?? Figure just start with one?
    yea, this is going to be a lot better then arimistane, I would start with 1 cap for a week and assess from there, without anything that could cause estrogen rise I would prolly stick at 1
  22. LETRONE FAQ!!!


    Quote Originally Posted by Jebrook View Post
    ^^^Yep. If you're not on anything strong just start with one cap. 2 month supply that way!
    We like that

    Will be stacking with Olympus LJ100, Ep1c Unleashed, forskolin, anabeta, and EC (currently on all)

  23. Quote Originally Posted by chedapalooza View Post
    Yea I'm between 1400-at most 1600 daily the extra cals from protein only. Fat is 30-45 and carbs always 30 or less.. I'm 152 9%. Been at it two months. Hurtin now lol. Trying to pull out all the stops. I just bought a bottle from TGB. I'm currently on 25mg daily of arimistane and will try dropping that and adding this in when it comes.

    Can anyone suggest 1 or 2 caps dosing?? Figure just start with one?
    Im not sure if I missed it elsewhere, but what else are you running cheda...?
    Serious Nutrition Solutions Rep / TGB Supplements.com Rep

    vujade5 @ TGB - Save 5% off upto $149 / vujade7 @ TGB - Save 7% over $150
  24. LETRONE FAQ!!!


    Quote Originally Posted by vujade View Post
    Im not sure if I missed it elsewhere, but what else are you running cheda...?
    EC with beast 2shredded
    25mg arimistane (will drop for this product)
    LJ100
    Ep1c Unleashed
    Forskolin 50mg
    Shift (50mg more forskolin)
    Compound20 (leftover bottles of old version)
    Anabeta original
    X gels
    High volume pre workout
    Myokem Mtor Pro
    Additional Agmatine
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