>>>the Right Way To Gain 10-15lbs In 15 Days With The One!!!<<<
- 04-07-2009, 02:45 PM
>>>the Right Way To Gain 10-15lbs In 15 Days With The One!!!<<<
As many of you have already heard, these gains are completely attainable by taking The One™; the completely new pro-anabolic compound exclusively by Applied Nutriceuticals®.
The following information will provide complete how-to instructions on diet, training, and supplementation based on the most recent research available combined with new data collected from people who have taken the product. By following these instructions, you can avoid making costly mistakes will gain a better understanding of how to use The One correctly as to maximize your results.
For additional detailed discussion on the science behind The One, you can log on to www.appnut.com/product-theone.php and click on “Technical Information” and “FAQs”.
You can also listen to an in-depth discussion on Superhuman Radio between Applied Nutriceuticals’ Chief Chemist Dirk Tanis and host Carl Lenore as they discuss The One and the science of hormone-based anabolics in general: Super Human Radio Network Show Number 269.
As with any endeavor, the best results are obtained when you have a good plan. Therefore, before taking The One, there are few things you should do to prepare your body for the explosive growth it is about to undergo.
1) Receptor cleansing: You should not have taken any other hormone-based anabolic/androgenic compound for at least 90 days prior to taking The One. This will allow for a greater number of the target androgen receptors (ARs) to be accessible for the active molecule in The One to exert it effects upon.
2) Training experience: The One is not for use for first-timers in the gym. We recommend that you have at least one year experience in weight training and are consistent and passionate about sticking to your regimen.
3) Contraindicated Products:Below is a non-exclusive list of prescription and non-prescription products that should not be taken in conjunction with The One and/or 2nd Gear:
a. Antibiotics: They will hinder re-absorption of The One by the intestine after first pass, as they kill the bacteria needed to change the molecule into a usable form.
b. Saw Palmetto (Serenoa repens): Competes with DHT for receptors; therefore significantly diminishes the ability for the active ingredient in The One to have any effect. Reference study: Planta Med. 2006 Jul;72(9):807-13. Epub 2006 Jun 19. Extracts from Pygeum africanum and other ethnobotanical species with antiandrogenic activity.Schleich S, Papaioannou M, Baniahmad A, Matusch R.Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marburg, Germany, Extracts from Serenoa repens and other similar botanicals are used in the treatment of benign prostatic hyperplasia (BPH) and prostate cancer (PCa). The activity of the AR is known to control growth of the prostate. Here, they examined extracts of these plants for their anti-androgenic activity using an AR responsive reporter gene assay for drug discovery.
c. Finasteride (Brand names: Proscar®, Propecia®): Reduces serum DHT activity by 70%; therefore it will virtually eliminate any results otherwise attainable from use of The One. Reference Study: J Clin Endocrinol Metab. 2007 May;92(5):1659-65. Epub 2007 Feb 13. The effect of 5alpha-reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy men.Amory JK, Wang C, Swerdloff RS, Anawalt BD, Matsumoto AM, Bremner WJ, Walker SE, Haberer LJ, Clark RV.
Department of Medicine, Veterans Affairs-Puget Sound Health Care System, University of Washington, Seattle, WA 98195, USA. CONTEXT: Dutasteride and finasteride are 5alpha-reductase inhibitors (5ARIs) that dramatically reduce serum levels of dihydrotestosterone (DHT). Because androgens are essential for fertility, we sought to determine the impact of 5ARI administration on serum testosterone (T), DHT, and spermatogenesis. DESIGN, SETTING, SUBJECTS, AND INTERVENTION: We conducted a randomized, double-blinded, placebo-controlled trial in 99 healthy men randomly assigned to receive dutasteride (D; 0.5 mg) (n = 33), finasteride (F; 5 mg) (n = 34), or placebo (n = 32) once daily for 1 yr. RESULTS: D and F significantly (P < 0.001) suppressed serum DHT, compared with placebo (D, 94%; F, 73%) and transiently increased serum T. These effects were found to be reversible after discontinuation.
d. Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) they will slow or stop the cascade effect by blocking prostaglandin biosynthesis. Prostaglandin biosynthesis is vitally important to the synthesis of protein, which is needed for growth and repair of skeletal muscle.
To get optimal results from The One we recommend you employ the use some type of volume training regimen. Charles Poliquin’s German Volume Training program is an excellent example of it. The reason we recommend volume training is because it overloads the muscle with a large number of sets and reps, which is a strong stimulus for hypertrophy as well as fascial stretching. Overloading via increased volume causes a whole host of metabolic changes within skeletal muscle; it can increase local IGF-1 levels, protein synthesis, and mechano growth factor (MGF).
Volume training provides the impetus for a strong stretch reflex in skeletal muscle tissue- and by this allows for a whole host of anabolic stimuli to occur along with it. Couple this stimuli with the increased hormone levels from The One, and explosive growth will occur due to the resulting synergistic hormonal interactions.
Oddly, this is an area where we have seen the most variability and mistakes that can negatively impact results from taking The One. Fortunately, it’s also the easiest to fix. In short, you have to eat, and eat a lot! This product is a strong GLUT4 repartitioner, meaning that it can allow increased amounts of glycogen to be shuttled into skeletal muscle at a more rapid rate and in much larger amounts than normal. We recommend you do not attempt a low-carb regimen while on The One, but here’s the good news: You can still get lean while taking in those carbs! The One works in both an Androgen Receptor (AR) and non-AR mediated fashion, meaning that while it binds the AR strongly and exerts some of its effects through this interaction, it also exerts effects that are not directly based on AR stimulation. From what we have observed, the potency of these effects can largely be influenced by dietary Kcal and carbohydrate intake.
A quick rule of thumb is below. Those with a high metabolism should use the higher end of the scale, those with a slow metabolism, use the lower end. If you ingest these ranges in good clean healthy foods, it is all you’ll need.
Carbohydrates: 1.5 – 3g / lb. of bodyweight
Protein: 1 – 1.5g / lb. of bodyweight
Fats: <100g / day
Am J Physiol Endocrinol Metab. 2008 May;294(5):E961-8. Epub 2008 Mar 1
Testosterone and DHEA activate the glucose metabolism-related signaling pathway in skeletal muscle.Sato K, Iemitsu M, Aizawa K, Ajisaka R.Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
The findings in this study suggest that skeletal muscle is capable of synthesizing DHT from testosterone, and that DHT activates the glucose metabolism-related signaling pathway in skeletal muscle cells.
So what does this mean? Keep your carbs and calories up. Even if you are trying to lose body fat while on this compound, you are in luck…you will lose body fat on The One (almost) regardless of what your total calorie intake is (again, within reason) because it does effect carbohydrate intake so strongly. This will also aid in increasing the already pre-existing increases in muscular volume and stretch from the volume training you are already partaking in, and further intensify these factors.
Certain supplements compliment The One very effectively, with Neovar and Omega Essentials being the two most important ones. Neovar increases local IGF-1 release and also GLUT4 translocation, and these two factors will act synergistically with some of the effects already incurred via The One.
Lastly, to help maintain overall health and a strong immune system, we recommend Bio-Mend, a powerful anti-oxidant that aids in cellular repair and Complete Balance, a full spectrum multi-vitamin.
We hope you have found this information useful and highly recommend you apply these principles to your cycle of The One. As always, we welcome individual questions which can be sent to [email protected].
Stay tuned for the next posting that details the everything you need to know your post-cycle regimen, including taking 2nd Gear, training, diet, and other ancillary supplementation.
Thank you for your business!
- 04-09-2009, 12:57 PM
The Second Half Of The Story...
OK, on to the topic of PCTs: Hope you find this helpful as well.
One of the most common inquiries we get has to do with how to administer proper post-cycle therapy (PCT) after using the One. There are a lot of differing opinions / advice floating around concerning the answer to this question and the purpose behind this document is to consolidate this information into a comprehensive and reliable guide that that is easy to understand and follow. The information is broken this into several sections:
- Understanding why you need PCT
- Common mistakes made during PCT, and how to fix them
- Exactly what to use, when and why
- How to prime yourself for your next cycle of The One
WHY DO I NEED PCT?
During your cycle of The One (or any other exogenous hormonal agent), your body's natural production of testosterone will most likely decline. This is caused by an inhibitory negative feedback loop involving the Hypothalamic-Pituitary-testicular Axis (HPTA), and can disrupt natural hormone levels. The extent to which the disruption occurs is based on several factors:
- history of personal use
- duration between cycles
- duration of the cycle
- dosages during the cycle
- type of supplements/nutrition implemented during cycle
- type of PCT undertaken
Manipulation of these factors can allow users of The One to lessen any negative effects encountered due to this disruption.
History of personal use is the first factor. The longer and more often you have used these types of compounds, the more you are going to be effected by them. The more days over the years that you spend 'on' vs. 'off', the less dependant your body will become on its own natural testosterone production. This lead into the next factor: duration between cycles. Time on should equal time off, or even greater- you have to give your endocrine system a break, and your gains will be better in the long run.
Duration of the actual cycle is another key factor. This plays back to history of personal use; the longer you are 'on', the greater the effect on the HPTA, and the longer it will take your endocrine system to get back to normal. This is why we recommend that you keep your cycle duration limited to 5 weeks or less for The One.
Dose is another factor; take no more that the recommended dosage, in fact we often say 'less is more' meaning, one capsule less is often better than one capsule more. The higher the dose, the greater the effect on the HPTA. If you follow good nutrition, rest, and train properly, you can gain just as much at a lower dosage.
This feeds into the next point; the types of supplements, nutrition, and training habits that you use during your cycle (and after) will dictate how well you recover from the cycle. Use a good anti-oxidant, multi-vitamin/mineral, and fish oil during your cycle. Train hard, but stick to a sound program and don'tover train. Sleep at least 7 hours per night, and avoid alcohol. In other words, just use common sense.
The last important point is that a proper PCT be followed. This is imperative, or you will not keep your gains, and may end up worse off than when you started. Certain supplements must be taken post-cycle to ensure that the HPTA is working properly. I compare not using a proper PCT to putting someone in a race car who does not know how to drive- they will go extremely fast, but will probably end up hurting themselves. Do your research, and follow these recommendations, and you will learn how to drive this vehicle correctly and safely.
COMMON MISTAKES MADE DURING PCT
A. Poor planning, with little or no steps taken to prepare for getting off The One
- Will result in loss of gains
- Will maximize any sides from product
B. Not enough Caloric (Kcal) intake
- Food is the most anabolic substance on the planet
- Cutting Kcals at the end of a cycle is the most catabolic (muscle wasting) things you can do to your body
C. Using too many PCT supplements
- Could alter hormone levels negatively
- Possible rebound effect of certain unwanted hormones (at least in elevated levels) such as estrogen, prolactin, or progesterone
- Disallows the ability to see what is working and what is not
D. Using the wrong type of PCT supplement
- Using certain compounds for PCT are unnecessary
- These compounds may produce unwanted interactions
E. Not training
- Skeletal muscle loses stimuli needed for growth
- Depression may set in
WHAT TO USE FOR PCT AFTER USING THE ONE AND WHEN
A. 2nd Gear
- Acts as a moderate anti-aromatase and keeps testosterone:estrogen ratio normalized
- Boosts endogenous testosterone levels back to normal levels
- Begin the day after your cycle of The One ends
B. Drive by Applied Nutriceuticals
- Forskolin, a component in Drive, increases cAMP levels, which increases LH levels and spermatogenesis, and will increase endogenous free testosterone levels.
- Icariin, another component in Drive, increases cGMP levels, which also plays a role in increasing spermatogenesis and increasing endogenous free testosterone levels
- Begin the day after your cycle of The One ends
C. IGF-2 by Applied Nutriceuticals
- Boosts endogenous testosterone and growth hormone levels
- Begin the day after your cycle of The One ends
D. Continue to consume ample calories
- Food is the most anabolic substance on the planet; studies have shown that when individuals eat above maintenance level, a whole host of anabolic processes occur- outside of the MOA by which The One operates
- Decreasing Kcals below maintenance post-cycle will result in a much lower retention of gains
- Lots of carbs, healthy fats and protein
- Keep Kcals a little above maintenance during PCT
- Should be applied both on cycle on The One, and for PCT
E. Neovar by Applied Nutriceuticals
- Boosts GLUT4 translocation and local IGF-1 levels- these are mechanisms of growth that can be utilized, even off-cycle
- Can be used on-cycle, as well as off
F. Bio Mend
- Strong anti-oxidant blend that ensures a healthy immune system
- Can be used on-cycle, as well as off
HOW TO PRIME YOURSELF FOR YOUR NEXT CYCLE OF THE ONE
- Have time on at least equal to time off; so if you ran The One for 1 month, take at least 1 month off (double is preferred); the longer the break, the better your gains the next time
- Do not piggy-back cycles- try to start your next cycle of The One after having not used any type of anabolic for at least 5-6 weeks.
Thanks again for your ongoing support and have fun getting huge!
If you have any further questions, always feel free to hit us up at [email protected].
- 04-10-2009, 04:00 PM
Good info - Can you explain further why fibasteride is an issue? iirc It reduces DHT via blocking the (mostly type II) 5AR enzyme, and I was under the impression that the One was active as is, ie does not undergo enzymatic conversion... In which case the blocking of 5AR should not have an impact. Am I mistaken on the MOA of The One, or am I missing something else?
04-10-2009, 07:37 PM
could you please comment about the best time to take the supplement and how many to take at a time... 3 in the morning? 2 in the morning and 1 6 hours later?
04-10-2009, 11:04 PM
The ONE (Straight OR Pulse)
Dose - 3-4 caps first thing in the morning
Dose 1 - 2-3 caps first thing in the morning
Dose 2 - 1-2* caps 4-6 hours later (taken no later than 2pm)
* (i.e. 2/1, 2/2, or 3/1; do NOT exceed more than 4 caps daily)
I recommend starting off at 3 caps daily, and after 2-3 weeks the bigger guys (>220lb) may want to increase to 4 caps for the last 1-2 weeks (but not necessary for anyone LESS than 220lb).
I also recommend starting off with Option A. If you start feeling lethargic in the afternoon, then move to Option B; or use a prewokout stimulant/product.
For every-other-day dosing: 67.5 mg for 3 weeks; 90 mg for 2 weeks; Mon/Wed/Fri. Follow with post cycle recommendations.
For 2 on 2 off: 67.5 mg for 3 weeks; 90 mg for 2 weeks; Mon/Tues, Fri/Sat. Follow with post cycle recommendations.
For 2 weeks on/2 off: 67.5 mg for two weeks, take 2 weeks off, repeat. Follow with post cycle recommendations.
04-11-2009, 10:06 PM
04-12-2009, 01:46 AM
04-12-2009, 01:20 PM
04-20-2009, 01:15 AM
04-20-2009, 01:20 AM
2nd Gear takes care of modulating estrogen and helps restore natural balance and function your hormones; but you ALSO want to kickstart your LH in PCT to help make your natural production of testosterone jump back to normal quicker (hence the testosterone booster).
I would use 2nd GEAR + Drive at the MINIMUM. I say Drive, because it also increases cAMP levels, which is also important.
(And you should still be using creatine, multivitamin, antioxidant, good fats, and protein powder).
04-20-2009, 02:26 AM
04-20-2009, 06:16 PM
04-21-2009, 05:32 PM
question: say you gain 15 lbs on your first cycle..then your off for your one month do you lose that 15 lbs or no?
04-21-2009, 05:42 PM
Hopefully not. I would say it would be pretty hard to lose all 15lbs of gains. But that depends on your PCT, eating and training.
04-21-2009, 06:14 PM
As long as your PCT is right, then you should maintain almost all, if not all, of your gains, and you might possibly even ADD to them. Provided that your diet and training are targeted at what you want and you're consistent with them.
If you mean that you would be stopping training for a month after finishing a cycle, then why would you WANT to do that? And if you were planning on it, why bother with a cycle?
04-21-2009, 08:38 PM
i said that cause dosnt it recomend taking a month off after you use it for a month? then you can get back on it..but no i wouldnt stop training. But what is PCT?
04-21-2009, 09:51 PM
You DON'T use The ONE for a month, take a month off, and then get back on it; that would be stupid.
The MINIMUM timeframe between the END of PCT for one product and the NEXT hormonal cycle is a month (ideally, maybe more).
If you are asking questions like this, and have no idea of what The ONE is, then, until you have done further research on it and the use of hormonal products, then I do NOT recommend that you use it!
Please make sure that you HAVE read ALL of the following threads on The ONE, as these threads contain all the information that you need to know about The ONE, as well as any possible questions and answers that you might have.
*>>>the Right Way To Gain 10-15lbs In 15 Days With The One!!!<<<
* >>>the Right Way To Gain 10-15lbs In 15 Days With The One!!!<<<
* 2009's biggest product is here- a sneak preview from AN
* It Is Here- AN's Write-Up for 2009's Biggest Product!!!!!!
* THE ONE!!!!! IMPORTANT RELEASE INFORMATION- WE HAVE SET A DATE!!
* THE ONE- BEAUTIFUL PACKAGING PLUS INFORMATION ABOUT ***FREE*** STUFF!!!!
* WAIT!!! Is “The ONE really enough???”
I also recommend reading up on The ONE (and 2nd GEAR) on the AN site:
* Applied Nutriceuticals - The ONE
* Applied Nutriceuticals - 2nd GEAR
04-22-2009, 01:53 AM
thats what im trying to do honestly i know some but not alot about it and am just trying to gather the most information as possible
04-22-2009, 07:18 AM
05-01-2009, 06:59 PM
Also, I understand you guys are running a business and are going to suggest your own products for PCT, but without naming products could someone provide other (ingredient) options? For example, I know of a topical made of resveratrol and 7,8-benzoflavone that I have yet to try but is supposed to help stimulate LH production and acts as an AI. This seems like a suitable addition to PCT.
05-01-2009, 08:46 PM
The main reason guys have issues on PCT is because their T:E gets too low and cortisol comes up during the cycle to counterbalance high T levels- so the goal in PCT is to keep E at bay while raising T levels and reducing cortisol concurrently. You tend to lose a good bit of LH activity on a heavy cycle due to androgen feedback on the HPTA, and when the AR in the pituitary and hypothalamus become heavily bound- GnRH no longer pulses, so no more LH or FSH is released into the blood. No LH, no signal to the testes to produce T or spermatogenesis. Carnitine levels also plunge significantly in the testes as well under these conditions- and this compound is vital in natural testosterone production/spermatogenesis.
Key is to keep carnitine levels stable, keep E at bay, lower cortisol, and to stimulate LH release, which will bring up T levels.
Some legitimate LH releasers
HCG- 250 iu 3x a week during a cycle will stop shutdown during a cycle
Forskolin @ 50 mg/day of 100% extract or equivalent lower dosage with lower extract- it increases cAMP better than anything else out there, which increases LH secretion.
Res-v is a decent choice @ 750 mg/day of the 100% extract- it increases cAMP, which increases LH secretion
E antagonists/aromatase inhibitors
6-Bromo @ 50 mg day- lowers estrogen levels and increases free testosterone in a non-suppressive manner
Clomid @ 50 mg/day- lowers estrogen levels and increases free test
Nolva @ 20 mg/day- lowers estrogen levels and increases free test
6,7 benzoflavone might be a good choice- it antagonizes the E receptor and can normalize T:E
Icariin @ 250 mg/day of 100% extract or equivalent lower dosage with lower extract- is a strong flavone that acts as both a SERM and a SARM and antagonizes E receptor so in this case 500 mg of the 50%, 1,250/day of the 20%, etc. Icariin also inhibits PDE-5 and increases cGMP and therefore NOS and NO- this allows for increased LH secretion as well (hint: 2nd Gear/Drive/ALCAR is a VERY good idea for PCT- RPM would be a good add-in as well).
ALCAR or L-Carnitine
2-4 grams per day will work wonders to get things up and running- it is a supp that has been around forever, but is phenomenal for a lot of different purposes
Recommendations for PCT
Dirk's recommendations (from what has worked for him) and does not allude to any specific product:
* 6- Bromo 50-100 mg/day (lowers E)
* Forskolin equivalent to 50 mg/day (increases LH)
* Creatine Mono 5 grams per day (keeps CP stores high- this will increase nitrogen retention naturally)
* Strong Anti-Oxidant (lowers cortisol levels and free radical damage)
* Omega 3's 2-3 grams/day (increases insulin sensitvity and normalizes cholesterol)
* Cissus Quadrangularis 1000 mg/day of 50% extract (keeps cortisol levels low)
* ALCAR 2-4 grams/day (keeps spermatogenesis going and helps maintain endogenous T)
05-01-2009, 09:18 PM
05-01-2009, 10:12 PM
Finasteride does reduce 5-AR, but it also decreases serum DHT by 70%. While this may be due to blocking the conversion, there might well be a chance that it is not necessarily due to a blockage of 5-AR, but may have more to do with competitive inhibition with the AR;- thus preventing DHT (or in this case DHT-like substances - i.e. The ONE) from binding the AR in skeletal muscle.
05-04-2009, 11:38 AM
05-04-2009, 05:27 PM
05-13-2009, 04:38 PM
You can definitely get away with only 2nd Gear for PCT with this stuff. I've done Epistane and Tren Xtreme before and used SERMS with those(both toremifene and tomoxifene citrate) and still lost a pretty good percentage of the gains. 4.5 weeks now have passed since I stopped The One and only used 2nd Gear for PCT. I've only gone down 2 lbs so far and zero strength losses.
EDIT: Well "only" 2nd Gear is a little bit of a lie. Gone through 2 bottles of Prime, also some beta alanine but nothing that really acts on hormones like a SERM.
05-13-2009, 04:48 PM
05-13-2009, 10:42 PM
05-13-2009, 11:25 PM
05-13-2009, 11:57 PM
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