d-serine and huperzine-a
- 06-05-2013, 04:06 AM
- 06-05-2013, 09:31 AM
06-05-2013, 06:50 PM
Why would dosing both be pointless?
Huperzine A deals with Acetylcholine and D-Serine activates the NMDA receptor.
If Racetams are intrinsic with D-Serine, you should be fine.
06-06-2013, 04:37 AM
06-06-2013, 02:46 PM
06-06-2013, 04:15 PM
In rats (scaled for HED), it takes about 33 mg of huperzine to restrict NMDA-induced excitotoxicty (in the epilepsy model). Kinetically (in humans), 1 mg of huperzine achieves a Cmax of 0.034 micromoles, whereas (in vitro) the NMDA IC50 of huperzine is 45.4 micromoles.
And although the data is fairly clear that no meaningful level of NMDA inhibition will occur with low-to-normal dosed huperzine, there are better alternatives available (i.e. galantamine).
06-06-2013, 04:41 PM
06-06-2013, 06:40 PM
06-06-2013, 09:41 PM
06-06-2013, 10:03 PM
06-06-2013, 10:17 PM
06-06-2013, 10:36 PM
For an acute study stack, I would opt for caffeine, galantamine, and maybe methylphenidate. Long term: DHA, galantamine, ALCAR, CDP-Choline/Alpha-GPC/adequate choline source. I wouldn't necessary reach for a racetam unless I was aged, or pathological.
06-06-2013, 11:02 PM
While I'm looking to employ a study stack for my professional exams, methylphenidate will make me pop USAW/USADA drug tests for my competitions. How about a substitute?
I've read your racetam article. I'm looking forward to part two.
06-06-2013, 11:10 PM
06-06-2013, 11:14 PM
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