17a hydroxy-pregna-1 4-diene-3 20-dione

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    Quote Originally Posted by Patrick Arnold View Post
    is this oral or topical?the dose just seems too tiny to be of any benefit. the stuff converts to boldione and boldione itself is known to be useless at 20mg a servingcorrect me if i am off base here
    Boldione needs a hell of a lot more than 200mg, let alone 20.
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    Quote Originally Posted by Beejis60 View Post
    Boldione needs a hell of a lot more than 200mg, let alone 20.

    but this one goes to 11
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    Wish there still was a legit bold pro hormone available like eq plex.
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    Is there any reason why any human being should trust or be giving any money to these supplement companies who seem to care about nothing but money and will lie all day and night to manipulate you? Lol
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    Quote Originally Posted by JD261985 View Post
    Is there any reason why any human being should trust or be giving any money to these supplement companies who seem to care about nothing but money and will lie all day and night to manipulate you? Lol
    That's why doing research on the compound is essential.
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    Quote Originally Posted by flightposite View Post
    Wish there still was a legit bold pro hormone available like eq plex.
    Why? That **** kinda sucked IMO.
    Quote Originally Posted by JD261985 View Post
    Is there any reason why any human being should trust or be giving any money to these supplement companies who seem to care about nothing but money and will lie all day and night to manipulate you?
    If someone is lying to you and manipulating you, do you REALLY need to ask if there's a reason to trust them? Or are you that dumb?
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    [QUOTE="Beejis60"]Why? That **** kinda sucked IMO.

    It was pretty mild. But it treated me very well. Zero sides, nice strength boost, appetite increase, good consistent lean mass gains, great mood, and my joints felt fantastic.
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    Quote Originally Posted by JD261985 View Post
    Is there any reason why any human being should trust or be giving any money to these supplement companies who seem to care about nothing but money and will lie all day and night to manipulate you? Lol
    i ask myself this every day
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    should i trust you, Pat?
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    Quote Originally Posted by bossman523 View Post
    should i trust you, Pat?
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    I meant reaction with Sodium bismuthate to make androstenedione and androstadiendione
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    wat?
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    Quote Originally Posted by YoungJD View Post
    I meant reaction with Sodium bismuthate to make androstenedione and androstadiendione
    that may acheive side chain clevage to give the latter compound. i am not sure
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    Quote Originally Posted by Patrick Arnold View Post
    that may acheive side chain clevage to give the latter compound. i am not sure
    What side chain?

    I know it's apparently a stronger oxidant than KMnO4, I just don't think it exhibits SET behavior. You'd probably have MUCH better luck using Nicolaou's IBX protocol... IDK, say, 4eq IBX in DMSO, 2d at 80*C inside the vessel ought to do the trick
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    the pregnane side chain.

    it usually requires previous reduction of the 20-keto group though

    we have done this before. we were trying to make 4-dhea starting from 17a-hydroxyprogesterone at one time. lead tetraacetete worked better, but the amount of lead left in the final product was troubling
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    Quote Originally Posted by Beejis60 View Post
    What side chain?

    I know it's apparently a stronger oxidant than KMnO4, I just don't think it exhibits SET behavior. You'd probably have MUCH better luck using Nicolaou's IBX protocol... IDK, say, 4eq IBX in DMSO, 2d at 80*C inside the vessel ought to do the trick

    IBX unfortunately tends to cause dehydrogenation reactions. u would end up with a considerable amount of 4,6
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    u should try to find a copy of carl djreassi's "steroid reactions" beejis
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    Quote Originally Posted by Patrick Arnold View Post
    the pregnane side chain.

    it usually requires previous reduction of the 20-keto group though

    we have done this before. we were trying to make 4-dhea starting from 17a-hydroxyprogesterone at one time. lead tetraacetete worked better, but the amount of lead left in the final product was troubling
    Wasn't he talking about from androstenedione? Amihigh?

    Quote Originally Posted by Patrick Arnold View Post
    IBX unfortunately tends to cause dehydrogenation reactions. u would end up with a considerable amount of 4,6
    Not with androstenedione as an SM... or even androstanedione JACS, 2002, 124(10), 2245. I've memorized all the Nicolaou/Baran IBX papers. This one is a particularly tricky reaction, but doable.

    Quote Originally Posted by Patrick Arnold View Post
    u should try to find a copy of carl djreassi's "steroid reactions" beejis
    three american dollars plus shipping? I'll take two.
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    Quote Originally Posted by Beejis60 View Post
    Wasn't he talking about from androstenedione? Amihigh?
    .
    i dunno, i thought he was talking about from 17a-OHP
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    Quote Originally Posted by Beejis60 View Post


    Not with androstenedione as an SM... or even androstanedione JACS, 2002, 124(10), 2245. I've memorized all the Nicolaou/Baran IBX papers. This one is a particularly tricky reaction, but doable.


    .
    U do recall that IBX in dmso was the method we used to make 1-ad (first step)

    It was a very nice reaction. It would give small amounts of 4-dione and 1,4-dione as side products though.

    It was much easier than the way we first made the product, which involved a bromination step followed by a debromination step
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    Quote Originally Posted by Patrick Arnold View Post
    U do recall that IBX in dmso was the method we used to make 1-ad (first step)

    It was a very nice reaction. It would give small amounts of 4-dione and 1,4-dione as side products though.

    It was much easier than the way we first made the product, which involved a bromination step followed by a debromination step
    At longer temps and a twat hair of water to initiate the 'enol' IBX form, conversion of androstanedione and androstenedione proceeds nicely to boldione. I guess I missed whatever you were talking about. Don't think I've ever seen anyone use bismuthate for oxidative cleavage though. Phil Baran blows out the 17-side chain of prednisone (similar steroidal structure to OHP) with NaIO4 quite nicely in his synthesis of Cortistatin A.
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    Quote Originally Posted by Beejis60 View Post
    At longer temps and a twat hair of water to initiate the 'enol' IBX form, conversion of androstanedione and androstenedione proceeds nicely to boldione. I guess I missed whatever you were talking about. Don't think I've ever seen anyone use bismuthate for oxidative cleavage though. Phil Baran blows out the 17-side chain of prednisone (similar steroidal structure to OHP) with NaIO4 quite nicely in his synthesis of Cortistatin A.
    there is a whole section on conversion of 20-ketosteroids to 17-ketosteroids in the djerassi book i mentioned.

    we used jones reagent in acetone to make the adrenosterone from hydrocortisone. If cortisone were commercially available we could have used a milder oxidizing reagent
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    Interesting that Jones Ox cleaves that side chain. Probably a bit cheaper than IBX but probably not as 'innocuous' as NaIO4. Can't imagine a ton of con. H2SO4 and CrO3 being cheap, safe, and "green". The workup of Jones Ox is beautiful though.
    Ordered that book at a solid $3.35. Gonna be my 2nd favorite book behind Dehydrobenzene and Cycloalkynes by Hoffmann.
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    what's up Beejis?
  

  
 

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