Technical Question About Transdermals

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    Technical Question About Transdermals


    If I make a simple transdermal out of water with just water-soluble ingredients, with DMSO as the carrier, and I added some amount of glycerin to help "thicken" it a bit, purely for ease of application, would this negatively effect the absorption of ingredients? I ask because I read glycerin penetrates only the first few layers of skin (not all 7), and then sits there drawing water into it. I'm wondering if instead of the ingredients penetrating all layers to the tissue with the help of DMSO as would normally happen, the glycerin will absorb the water (with the ingredients diluted into it) while it sits in a more superficial layer of skin, and prevent it from going as deep as it should.

    I also wondered if thickening the formulation with some cellulose derivative would be better, but those basically work by absorbing mass amounts of water when you mix them in. They also doesn't penetrate the skin at all--so, in theory most of the transdermal would just sit atop the skin with the cellulose it was absorbed into. Is this correct?

    Sorry if these questions are a bit involved.

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    what are the water soluble ingredients? unless they also have some lipid solubility they arent gonna absorb much
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    Well I'm thinking micronized magnesium. Will the ingredients I mentioned (glycerin or calluloses) hinder it's absorption any more than if I didn't indlude them?
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    Quote Originally Posted by tstarks View Post
    Well I'm thinking micronized magnesium. Will the ingredients I mentioned (glycerin or calluloses) hinder it's absorption any more than if I didn't indlude them?

    magnesium what?

    micronized magnesium metal can easily burst into flames upon exposure to air
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    I assume he is trying to make a magnesium oil like those being sold so I will take a guess at magnesium chloride.
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    Quote Originally Posted by bdcc View Post
    I assume he is trying to make a magnesium oil like those being sold so I will take a guess at magnesium chloride.

    i dont know anything about this. My guess is that it cant absorb effectively because the system has no affinity for lipids. But maybe he is only interested in getting magnesium into the upper layers of skin?

    what is the point anyway? trouble absorbing oral magnesium supps?
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    Well, I honestly haven't really made up my mind yet about which ingredients I'm using. magnesium was just one idea (oxide, by the way). Maybe I'll add some oleic acid + emulsifier to make it more lipid friendly, that's a good idea. I was just wondering mainly about the glycerin and the cellulose questions; seems like something a chemist would know, and I don't really know where else to post the question...
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    Quote Originally Posted by tstarks View Post
    Well, I honestly haven't really made up my mind yet about which ingredients I'm using. magnesium was just one idea (oxide, by the way). Maybe I'll add some oleic acid + emulsifier to make it more lipid friendly, that's a good idea.

    it wont make your magnesium chloride more lipid friendly
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    I see. If an already lipid-friendly active material used, would the aforementioned thickeners interfere with absorption then?
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    Quote Originally Posted by tstarks View Post
    I see. If an already lipid-friendly active material used, would the aforementioned thickeners interfere with absorption then?
    polymer thickeners shouldnt make a difference. the liquid and active will still diffuse while the polymer stays on the surface of the skin
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    Good ****, thanks PA
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    Ok, PA

    Love the sprays, love 100% coconut oil as a moisturizer, love magnesium oil topical.

    How might coconut oil or magnesium oil disrupt UR spray, pump spray, r spray?

    I what order and what type of spacing should I shoot for between application of your sprays and coconut oil?
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    Quote Originally Posted by Lutztenways View Post
    Ok, PA

    Love the sprays, love 100% coconut oil as a moisturizer, love magnesium oil topical.

    How might coconut oil or magnesium oil disrupt UR spray, pump spray, r spray?

    I what order and what type of spacing should I shoot for between application of your sprays and coconut oil?

    I dunno but it might disprupt. I would shower and put on the sprays and then a few hours later perhaps use the other stuff.
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    Quote Originally Posted by Patrick Arnold View Post
    what are the water soluble ingredients? unless they also have some lipid solubility they arent gonna absorb much
    How do you find out information about this? I mean like short of getting a degree in chemistry. Are there online resources? I make a homemade msm cream to help with my rosacea since a study showed that a msm and milk thistle cream was effective in treating rosacea. I know from googling around that you can just dissolve msm powder in distilled water and add it to a sensitive skin lotion cream but I could never find out if I could just do the same with opening up some milk thistle caps
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    The same thing with vitamin k which theoretically would help with the rosacea redness, could I just crush vitamin k pills and add them to my skin lotion. The reason I have to make the cream is because rosacea is notoriously sensitive to a ****losd of things so if I just buy a premade cream a lot of them contain ingredients which would just aggravate the condition
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    I hate to be a pain in the ass here, but can I just break these milk thistle caps open here and add them to distilled water and they'll be absorbed by my skin..I was googling again today and I can't figure this **** out.
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    Quote Originally Posted by Quadzilla99 View Post
    I hate to be a pain in the ass here, but can I just break these milk thistle caps open here and add them to distilled water and they'll be absorbed by my skin..I was googling again today and I can't figure this **** out.
    lol no.
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