17b-HSD1 and 17b-HSD5

  1. New Member
    mrmello's Avatar
    Stats
    5'11"  189 lbs.
    Join Date
    Dec 2012
    Posts
    79
    Rep Power
    13515
    Level
    9
    Lv. Percent
    91.28%

    17b-HSD1 and 17b-HSD5


    hey Pat,

    I was wondering if theres any substance know to increase endogenous levels of the 17b-HSD1 and 17b-HSD5 enzimes.

    Those are responsible for hydrolizing Trenavar into Trenbolone by working the Ketone bond. Since this is a rate limiting factor I wondered if theres anything I can do to upregulate this convertion, or if any substances are know to inhibit or downregulate those enzimes?


    On another subject, after countless searches for 11-oxo, I found one of your posts leading to Prototype Nutrition. Do you know if 11-oxo is more effective then the 7-keto family Androsta-3,5-diene-7,17-dione , regarding conrtisone-cortisol convertion ?

  2. Featured Author
    Patrick Arnold's Avatar
    Join Date
    Apr 2007
    Posts
    4,119
    Rep Power
    554327
    Level
    50
    Lv. Percent
    40.64%
    Achievements Activity ProPosting Pro

    you can take NADH supplements as they will promote reduction at C17 by effecting the redox direction of those enzymes. Ethanol can temporarily switch the redox ratio towards reduction as well, but thats not a long term solution of course

    If you took an excess of steroid that has a 17b-OH group (beta-AET for exacmple) that may also could change the redox towards reduction and activation for the 17keto steroid

    11-oxo should be better than 7-keto. the androsta35 you mention has no evidence for it that it effects that enzyme that i am aware of. it is being promotoed for that for some reason
    Anabolicminds.com Featured Author
  3. New Member
    mrmello's Avatar
    Stats
    5'11"  189 lbs.
    Join Date
    Dec 2012
    Posts
    79
    Rep Power
    13515
    Level
    9
    Lv. Percent
    91.28%

    Greatly appreciated Patrick.

    Word... I read that the androsta 35 compound MAY prevent cortisone -cortisol convertion by keeping the 11-Beta-HSD1 Enzyme ''busy'' metabolizing the 7-keto compound... thus by some sort of competitive inhibbition. But as mentioned couldnal evidence.. even blood work seems to be lacking on this.

    Ok and also... any idea of when the Urspray (prototype nutrition) will be avaliable again?
    •   
       

  4. Featured Author
    Patrick Arnold's Avatar
    Join Date
    Apr 2007
    Posts
    4,119
    Rep Power
    554327
    Level
    50
    Lv. Percent
    40.64%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by mrmello View Post
    Greatly appreciated Patrick.

    Word... I read that the androsta 35 compound MAY prevent cortisone -cortisol convertion by keeping the 11-Beta-HSD1 Enzyme ''busy'' metabolizing the 7-keto compound... thus by some sort of competitive inhibbition. But as mentioned couldnal evidence.. even blood work seems to be lacking on this.

    Ok and also... any idea of when the Urspray (prototype nutrition) will be avaliable again?
    7keto-dhea is known to affect that enzyme but the compound in question is different in structure in a pretty significant manner. substarates fit into enzymes like a lock and key remember
    Anabolicminds.com Featured Author
  5. Diamond Member
    mr.cooper69's Avatar
    Join Date
    Feb 2011
    Posts
    10,685
    Rep Power
    6897331
    Level
    99
    Lv. Percent
    73.54%
    Achievements Activity AuthorityActivity ProActivity VeteranActivity RoyaltyPosting Pro

    Quote Originally Posted by Patrick Arnold View Post
    substarates fit into enzymes like a lock and key remember
    You know how I know you're old?

    Induced fit bro
    http://pescience.com/
    http://selectprotein.com/
    The above is my own opinion and does not reflect the opinion of PES
  6. Featured Author
    Patrick Arnold's Avatar
    Join Date
    Apr 2007
    Posts
    4,119
    Rep Power
    554327
    Level
    50
    Lv. Percent
    40.64%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by mr.cooper69 View Post
    You know how I know you're old?

    Induced fit bro

    hey i know its not quite like a lock and key. the ligand and receptor interact (i.e. electrostatically) and change conformations a bit and then bind. but for the simple folk on here its easy to just use that old analogy
    Anabolicminds.com Featured Author
  

  
 

Similar Forum Threads

  1. H-DROL 17b-ol vs 17b-diol whats the diff?
    By dugan661 in forum Supplements
    Replies: 10
    Last Post: 11-25-2009, 11:31 PM
  2. 17b-Methoxytrienosterone Analysis (FTIR)
    By DR.D in forum Anabolics
    Replies: 46
    Last Post: 07-28-2007, 09:30 AM
  3. High BP and 17b methoxy-trienbolone
    By littlemack in forum Anabolics
    Replies: 13
    Last Post: 09-13-2006, 10:36 PM
  4. High BP and 17b methoxy-trienbolone
    By littlemack in forum Supplements
    Replies: 0
    Last Post: 09-13-2006, 06:08 PM
  5. 17b-hydroxyandrostene 1-3 for PCT? help!
    By Sparetire in forum Anabolics
    Replies: 0
    Last Post: 05-14-2005, 09:45 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Log in
Log in