Ethosome-encapsulated transdermal ursolic acid

  1. Ethosome-encapsulated transdermal ursolic acid


    toughs?


    [Preparation and transdermal diffu... [Zhongguo Zhong Yao Za Zhi. 2011] - PubMed - NCBI


    Zhongguo Zhong Yao Za Zhi. 2011 Apr;36(8):988-91.
    [Preparation and transdermal diffusion of ursolic acid ethosomes].
    Chen Y, Wiu Q, Zhang Z, Zhou L, Liu X, Du M, Jia X.

    To prepare ursolic acid ethosomes and investigate the penetration characteristics of ursolic ethosomes as a transdermal vehicle.

    METHOD:

    Ursolic acid ethosomes were prepared by injection method, and the shape and particle size of the ethosomes were analyzed. Ursolic acid permeation tests in vitro through the skin of rats were performed in TP-3 diffusion cell. The accumulated permeation amounts of ursolic acid 10% isopropanol solution, ursolic acid liposomes, ursolic acid ethosomes were compared.

    RESULT:

    The average encapsulation percentage, particle size, and Zeta potential of the ethosomes were (95.83 +/- 0.86)%, (87.5 +/- 7.5) nm and - (38.4 +/- 3.6) mV, respectively. The accumulated permeation amount of the ethosomes in 12 h was 146.49 microg x cm(-2), and its transdermal permeability in 12 h was 12.17 microg x cm(-2) x h(-1).

    CONCLUSION:

    The encapsulation percentage of the ethosomes is good, and the stability of the ursolic acid ethosomes is fine. Ethosomes can significantly enhance the diffusion rate of ursolic acid through the skin of rats.


  2. Nice find.

  3. i dont know much about this technology.

    i cant know everything!
    Anabolicminds.com Featured Author
    •   
       


  4. Quote Originally Posted by Patrick Arnold View Post
    i dont know much about this technology.

    i cant know everything!
    Read up and answer , looks interesting, and getting a response from the Ursolic Acid Master would actually be quite interesting.
    >SNS-Glycophase<
    Serious Nutrition Solutions Rep

  5. i dont know how to make these ethosomes
    Anabolicminds.com Featured Author

  6. Quote Originally Posted by Patrick Arnold View Post
    i dont know how to make these ethosomes
    google it! LOL

  7. Quote Originally Posted by tilldeath View Post
    google it! LOL
    i dont wanna make ethosomes.

    i already got a pretty nifty ursolic derivative

    and also got some university guy working on other methods to increase bioavailbilty
    Anabolicminds.com Featured Author

  8. Quote Originally Posted by Patrick Arnold View Post
    i dont wanna make ethosomes.

    i already got a pretty nifty ursolic derivative

    and also got some university guy working on other methods to increase bioavailbilty
    Hm...In the meantime UR Spray is still the best way to get Ursolic Acid levels high enough in a cost-effective way to use it for body re-composition purposes anyway.
    >SNS-Glycophase<
    Serious Nutrition Solutions Rep

  9. Quote Originally Posted by Patrick Arnold

    i dont wanna make ethosomes.

    i already got a pretty nifty ursolic derivative

    and also got some university guy working on other methods to increase bioavailbilty
    In for use and abuse

    Sent from my Inspire 4G using Am.com
    SNS Online Representative
    Maxximal @ seriousnutritionsolutions.com

    Got Glycophase ...?



  10. Quote Originally Posted by Celorza View Post
    Hm...In the meantime UR Spray is still the best way to get Ursolic Acid levels high enough in a cost-effective way to use it for body re-composition purposes anyway.
    it seems to be working pretty nice
    Anabolicminds.com Featured Author

  11. Quote Originally Posted by Patrick Arnold View Post
    it seems to be working pretty nice
    Yeah Truth seems to be making awesome progress, but then again he is a beast too haha, trains and diets real good.
    >SNS-Glycophase<
    Serious Nutrition Solutions Rep

  12. Quote Originally Posted by Patrick Arnold

    it seems to be working pretty nice
    It's working for me. I think it's going to stay a staple of my sups.

  13. We will see how it works on someone like me who is much younger and also much less of a beast than Truth. I won't be cutting or really even recomping...Ur Spray+ecto=?

    SHould be here tomorrow.
  

  
 

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