Ursolic acid increases muscle mass, BAT and reduces diet-induced obesity in mice

[Angelbolic]

This was published yesterday by the same authors as the Cell paper:

Ursolic Acid Increases Skeletal Muscle and Brown Fat and Decreases Diet-Induced Obesity, Glucose Intolerance and Fatty Liver Disease

Skeletal muscle Akt activity stimulates muscle growth and imparts resistance to obesity, glucose intolerance and fatty liver disease. We recently found that ursolic acid increases skeletal muscle Akt activity and stimulates muscle growth in non-obese mice. Here, we tested the hypothesis that ursolic acid might increase skeletal muscle Akt activity in a mouse model of diet-induced obesity. We studied mice that consumed a high fat diet lacking or containing ursolic acid. In skeletal muscle, ursolic acid increased Akt activity, as well as downstream mRNAs that promote glucose utilization (hexokinase-II), blood vessel recruitment (Vegfa) and autocrine/paracrine IGF-I signaling (Igf1). As a result, ursolic acid increased skeletal muscle mass, fast and slow muscle fiber size, grip strength and exercise capacity. Interestingly, ursolic acid also increased brown fat, a tissue that shares developmental origins with skeletal muscle. Consistent with increased skeletal muscle and brown fat, ursolic acid increased energy expenditure, leading to reduced obesity, improved glucose tolerance and decreased hepatic steatosis. These data support a model in which ursolic acid reduces obesity, glucose intolerance and fatty liver disease by increasing skeletal muscle and brown fat, and suggest ursolic acid as a potential therapeutic approach for obesity and obesity-related illness.

http://www.plosone.org/article/info%...l.pone.0039332

[Patrick Arnold]

awesome, i gotta read. u beat me to this

[Royd The Noyd]

Intradasting

[Patrick Arnold]

increases food intake was an interesting finding

the brown fat thing could explain why some people feel hot

[Angelbolic]

It's interesting that ursolic acid's effects on (grip) strength and muscle mass were the same for the 0.14% and 0.27% dose. From memory, in the Cell paper the peak effect on muscle mass was also seen in the 0.14% group. This translates to a HED of 16.8 mg/kg or about 1700mg for a 220lbs male.

I've seen some anecdotes about 'megadosing' ursolic acid orally, but logs indicate that your spray is even more effective. One of the explanations is increased solubility and bioavailability, but that doesn't make much sense to me because the mice took it orally (mixed in their chow) and the peak effect on muscle mass was seen in the 0.14% group. So if these anecdotes/logs hold up, it seems more likely that for whatever reason the usual HED formula is not applicable to ursolic acid. Or am I missing something??

[T-Bone]

It's interesting that ursolic acid's effects on (grip) strength and muscle mass were the same for the 0.14% and 0.27% dose. From memory, in the Cell paper the peak effect on muscle mass was also seen in the 0.14% group. This translates to a HED of 16.8 mg/kg or about 1700mg for a 220lbs male.

I've seen some anecdotes about 'megadosing' ursolic acid orally, but logs indicate that Patrick's spray is even more effective. One of the explanations is increased solubility and bioavailability, but that doesn't make much sense to me because the mice took it orally (mixed in their chow) and the peak effect on muscle mass was seen in the 0.14% group. So if these anecdotes/logs hold up, it seems more likely that for whatever reason the usual HED formula is not applicable to ursolic acid. Or am I missing something??

The thing that puzzles me about the spray is that people are starting to take double the recommended dosage on that also, so I think whether it works better or not is still up in the air.

[Patrick Arnold]

It's interesting that ursolic acid's effects on (grip) strength and muscle mass were the same for the 0.14% and 0.27% dose. From memory, in the Cell paper the peak effect on muscle mass was also seen in the 0.14% group. This translates to a HED of 16.8 mg/kg or about 1700mg for a 220lbs male.

I've seen some anecdotes about 'megadosing' ursolic acid orally, but logs indicate that Patrick's spray is even more effective. One of the explanations is increased solubility and bioavailability, but that doesn't make much sense to me because the mice took it orally (mixed in their chow) and the peak effect on muscle mass was seen in the 0.14% group. So if these anecdotes/logs hold up, it seems more likely that for whatever reason the usual HED formula is not applicable to ursolic acid. Or am I missing something??

i am not entirely sure if the mice digestive system is comparable to human. they may have much greater permeability in their gut allowing them to absorb the stuff better. but yeah, its a curious point u bring up.

[Celorza]

The thing that puzzles me about the spray is that people are starting to take double the recommended dosage on that also, so I think whether it works better or not is still up in the air.

When I asked Truth about the reason behind his 2x dosage (Thinking it was weight/height related) he answered: "It was Patrick's idea and suggestion actually" So maybe PA can shed some light behind this?

[Patrick Arnold]

When I asked Truth about the reason behind his 2x dosage (Thinking it was weight/height related) he answered: "It was Patrick's idea and suggestion actually" So maybe PA can shed some light behind this?

more is better. but three times a day i think would be a waste

[Celorza]

more is better. but three times a day i think would be a waste

Hm yeah I do agree, and I ain't gonna shower more than twice a day haha

[mr.cooper69]

It's interesting that ursolic acid's effects on (grip) strength and muscle mass were the same for the 0.14% and 0.27% dose. From memory, in the Cell paper the peak effect on muscle mass was also seen in the 0.14% group. This translates to a HED of 16.8 mg/kg or about 1700mg for a 220lbs male.

I've seen some anecdotes about 'megadosing' ursolic acid orally, but logs indicate that your spray is even more effective. One of the explanations is increased solubility and bioavailability, but that doesn't make much sense to me because the mice took it orally (mixed in their chow) and the peak effect on muscle mass was seen in the 0.14% group. So if these anecdotes/logs hold up, it seems more likely that for whatever reason the usual HED formula is not applicable to ursolic acid. Or am I missing something??

Compartmentalization and volume of distribution often differ between humans and mice. Solubility is one factor that can confound an HED or render it altogether irrelevant.