Thank you for this!
I really tire of seeing people throw around the word "proven" or "fact" or any other equivalent when discussing if something is effective or not. Everything really is just a theory not facts. There are very few "facts" or "laws" in science and even then these are all just theories. Hell the law stating all organic life must be comprised of carbon, oxygen, hydrogen, nitrogen & phosphorus was accepted as fact for decades and recently scientist discovered an arsenic-based life form that defies this "law".
Point being there are no facts or proven ingredients, only theories.