Systemic nicotine stimulates human adipose tissue lipolysis through local cholinergic and catecholaminergic receptors.
seems if you can use it without the harmful effects of smoking to get desired levels, it works well.
and is fairly safe
ScienceDirect - Journal of Steroid Biochemistry : The effects of nicotine, cotinine and anabasine on rat adrenal 11β-hydroxylase and 21-hydroxylase
this shows inhibition on 11b hsd and 21 hydroxylase which both effect cortisol and possible glucodcorticoid, granted in rats.
other studies use it for ulcerative colitis which colitis (itis meaning inflamation) which shows reduced inflammation.
Other studies showing it to aid in anti aromatase activities. reduce hunger (which is weird due to an enhanced NPY expression in rat hypothalamus ScienceDirect - Brain Research : Nicotine administration enhances NPY expression in the rat hypothalamus.). But this says opposite ScienceDirect - Brain Research : Nicotine administration decreases neuropeptide Y expression and increases leptin receptor expression in the hypothalamus of food-deprived rats
Granted there are certain negative effects. But nicotine in its purest form seems to be not bad aside from probably activating the CART or POMC in some way.
shed some light.
seems if you can use it without the harmful effects of smoking to get desired levels, it works well.
and is fairly safe
ScienceDirect - Journal of Steroid Biochemistry : The effects of nicotine, cotinine and anabasine on rat adrenal 11β-hydroxylase and 21-hydroxylase
this shows inhibition on 11b hsd and 21 hydroxylase which both effect cortisol and possible glucodcorticoid, granted in rats.
other studies use it for ulcerative colitis which colitis (itis meaning inflamation) which shows reduced inflammation.
Other studies showing it to aid in anti aromatase activities. reduce hunger (which is weird due to an enhanced NPY expression in rat hypothalamus ScienceDirect - Brain Research : Nicotine administration enhances NPY expression in the rat hypothalamus.). But this says opposite ScienceDirect - Brain Research : Nicotine administration decreases neuropeptide Y expression and increases leptin receptor expression in the hypothalamus of food-deprived rats
Granted there are certain negative effects. But nicotine in its purest form seems to be not bad aside from probably activating the CART or POMC in some way.
shed some light.